Summary | |
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Symbol | CNGB3 |
Name | cyclic nucleotide gated channel beta 3 |
Aliases | ACHM3; ACHM1; RMCH; achromatopsia (rod monochromacy) 3; achromatopsia (rod monochromacy) 1; CNG channel beta ...... |
Chromosomal Location | 8q21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Membrane; Multi-pass membrane protein. |
Domain |
PF00027 Cyclic nucleotide-binding domain |
Function |
Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cGMP which leads to an opening of the cation channel and thereby causing a depolarization of rod photoreceptors. Induced a flickering channel gating, weakened the outward rectification in the presence of extracellular calcium, increased sensitivity for L-cis diltiazem and enhanced the cAMP efficiency of the channel when coexpressed with CNGA3 (By similarity). Essential for the generation of light-evoked electrical responses in the red-, green- and blue sensitive cones. |
Biological Process |
GO:0006813 potassium ion transport GO:0007601 visual perception GO:0015672 monovalent inorganic cation transport GO:0042391 regulation of membrane potential GO:0050953 sensory perception of light stimulus GO:0071804 cellular potassium ion transport GO:0071805 potassium ion transmembrane transport |
Molecular Function |
GO:0005216 ion channel activity GO:0005217 intracellular ligand-gated ion channel activity GO:0005221 intracellular cyclic nucleotide activated cation channel activity GO:0005222 intracellular cAMP activated cation channel activity GO:0005223 intracellular cGMP activated cation channel activity GO:0005244 voltage-gated ion channel activity GO:0005249 voltage-gated potassium channel activity GO:0005261 cation channel activity GO:0005267 potassium channel activity GO:0015077 monovalent inorganic cation transmembrane transporter activity GO:0015079 potassium ion transmembrane transporter activity GO:0015267 channel activity GO:0015276 ligand-gated ion channel activity GO:0019001 guanyl nucleotide binding GO:0022803 passive transmembrane transporter activity GO:0022832 voltage-gated channel activity GO:0022834 ligand-gated channel activity GO:0022836 gated channel activity GO:0022838 substrate-specific channel activity GO:0022843 voltage-gated cation channel activity GO:0030551 cyclic nucleotide binding GO:0030553 cGMP binding GO:0032561 guanyl ribonucleotide binding GO:0043855 cyclic nucleotide-gated ion channel activity GO:0046873 metal ion transmembrane transporter activity |
Cellular Component |
GO:0001750 photoreceptor outer segment GO:0005929 cilium GO:0031513 nonmotile primary cilium GO:0072372 primary cilium GO:1902495 transmembrane transporter complex GO:1990351 transporter complex |
KEGG |
hsa04024 cAMP signaling pathway |
Reactome | - |
Summary | |
---|---|
Symbol | CNGB3 |
Name | cyclic nucleotide gated channel beta 3 |
Aliases | ACHM3; ACHM1; RMCH; achromatopsia (rod monochromacy) 3; achromatopsia (rod monochromacy) 1; CNG channel beta ...... |
Chromosomal Location | 8q21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between CNGB3 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | CNGB3 |
Name | cyclic nucleotide gated channel beta 3 |
Aliases | ACHM3; ACHM1; RMCH; achromatopsia (rod monochromacy) 3; achromatopsia (rod monochromacy) 1; CNG channel beta ...... |
Chromosomal Location | 8q21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of CNGB3 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | CNGB3 |
Name | cyclic nucleotide gated channel beta 3 |
Aliases | ACHM3; ACHM1; RMCH; achromatopsia (rod monochromacy) 3; achromatopsia (rod monochromacy) 1; CNG channel beta ...... |
Chromosomal Location | 8q21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of CNGB3 in various data sets.
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Points in the above scatter plot represent the mutation difference of CNGB3 in various data sets.
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Summary | |
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Symbol | CNGB3 |
Name | cyclic nucleotide gated channel beta 3 |
Aliases | ACHM3; ACHM1; RMCH; achromatopsia (rod monochromacy) 3; achromatopsia (rod monochromacy) 1; CNG channel beta ...... |
Chromosomal Location | 8q21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of CNGB3. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | CNGB3 |
Name | cyclic nucleotide gated channel beta 3 |
Aliases | ACHM3; ACHM1; RMCH; achromatopsia (rod monochromacy) 3; achromatopsia (rod monochromacy) 1; CNG channel beta ...... |
Chromosomal Location | 8q21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of CNGB3. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by CNGB3. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | CNGB3 |
Name | cyclic nucleotide gated channel beta 3 |
Aliases | ACHM3; ACHM1; RMCH; achromatopsia (rod monochromacy) 3; achromatopsia (rod monochromacy) 1; CNG channel beta ...... |
Chromosomal Location | 8q21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of CNGB3. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | CNGB3 |
Name | cyclic nucleotide gated channel beta 3 |
Aliases | ACHM3; ACHM1; RMCH; achromatopsia (rod monochromacy) 3; achromatopsia (rod monochromacy) 1; CNG channel beta ...... |
Chromosomal Location | 8q21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of CNGB3 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | CNGB3 |
Name | cyclic nucleotide gated channel beta 3 |
Aliases | ACHM3; ACHM1; RMCH; achromatopsia (rod monochromacy) 3; achromatopsia (rod monochromacy) 1; CNG channel beta ...... |
Chromosomal Location | 8q21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between CNGB3 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | CNGB3 |
Name | cyclic nucleotide gated channel beta 3 |
Aliases | ACHM3; ACHM1; RMCH; achromatopsia (rod monochromacy) 3; achromatopsia (rod monochromacy) 1; CNG channel beta ...... |
Chromosomal Location | 8q21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting CNGB3 collected from DrugBank database. |
There is no record. |