Summary | |
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Symbol | CNIH2 |
Name | cornichon family AMPA receptor auxiliary protein 2 |
Aliases | MGC50896; CNIH-2; cornichon homolog 2 (Drosophila); cornichon homolog 2; Cornichon-like protein; Protein cor ...... |
Chromosomal Location | 11q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Endoplasmic reticulum membrane Multi-pass membrane protein Cell junction, synapse, postsynaptic cell membrane Multi-pass membrane protein Cell projection, dendrite Cell projection, dendritic spine Cell junction, synapse, postsynaptic cell membrane, postsynaptic density Note=Also localizes to the cell membrane of extrasynaptic sites (dendritic shafts, spines of pyramidal cells). |
Domain |
PF03311 Cornichon protein |
Function |
Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by regulating their rates of activation, deactivation and desensitization. Blocks CACNG8-mediated resensitization of AMPA receptors. |
Biological Process |
GO:0006888 ER to Golgi vesicle-mediated transport GO:0006900 membrane budding GO:0006901 vesicle coating GO:0006903 vesicle targeting GO:0007018 microtubule-based movement GO:0007215 glutamate receptor signaling pathway GO:0007270 neuron-neuron synaptic transmission GO:0008088 axo-dendritic transport GO:0008089 anterograde axonal transport GO:0010469 regulation of receptor activity GO:0010970 transport along microtubule GO:0016050 vesicle organization GO:0022898 regulation of transmembrane transporter activity GO:0030705 cytoskeleton-dependent intracellular transport GO:0031503 protein complex localization GO:0032386 regulation of intracellular transport GO:0032387 negative regulation of intracellular transport GO:0032409 regulation of transporter activity GO:0032412 regulation of ion transmembrane transporter activity GO:0032886 regulation of microtubule-based process GO:0034762 regulation of transmembrane transport GO:0034765 regulation of ion transmembrane transport GO:0035249 synaptic transmission, glutamatergic GO:0035418 protein localization to synapse GO:0042391 regulation of membrane potential GO:0047496 vesicle transport along microtubule GO:0048193 Golgi vesicle transport GO:0048199 vesicle targeting, to, from or within Golgi GO:0048207 vesicle targeting, rough ER to cis-Golgi GO:0048208 COPII vesicle coating GO:0048489 synaptic vesicle transport GO:0048490 anterograde synaptic vesicle transport GO:0051051 negative regulation of transport GO:0051271 negative regulation of cellular component movement GO:0051640 organelle localization GO:0051648 vesicle localization GO:0051650 establishment of vesicle localization GO:0051656 establishment of organelle localization GO:0051668 localization within membrane GO:0060627 regulation of vesicle-mediated transport GO:0060632 regulation of microtubule-based movement GO:0072384 organelle transport along microtubule GO:0090114 COPII-coated vesicle budding GO:0097120 receptor localization to synapse GO:0097479 synaptic vesicle localization GO:0097480 establishment of synaptic vesicle localization GO:0098930 axonal transport GO:0099514 synaptic vesicle cytoskeletal transport GO:0099517 synaptic vesicle transport along microtubule GO:0099518 vesicle cytoskeletal trafficking GO:0099601 regulation of neurotransmitter receptor activity GO:1900449 regulation of glutamate receptor signaling pathway GO:1901608 regulation of vesicle transport along microtubule GO:1901609 negative regulation of vesicle transport along microtubule GO:1902473 regulation of protein localization to synapse GO:1902513 regulation of organelle transport along microtubule GO:1902683 regulation of receptor localization to synapse GO:1902684 negative regulation of receptor localization to synapse GO:1902803 regulation of synaptic vesicle transport GO:1902804 negative regulation of synaptic vesicle transport GO:1903742 regulation of anterograde synaptic vesicle transport GO:1903743 negative regulation of anterograde synaptic vesicle transport GO:2000310 regulation of N-methyl-D-aspartate selective glutamate receptor activity GO:2000311 regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity |
Molecular Function | - |
Cellular Component |
GO:0005793 endoplasmic reticulum-Golgi intermediate compartment GO:0008328 ionotropic glutamate receptor complex GO:0012507 ER to Golgi transport vesicle membrane GO:0014069 postsynaptic density GO:0030133 transport vesicle GO:0030134 ER to Golgi transport vesicle GO:0030135 coated vesicle GO:0030425 dendrite GO:0030658 transport vesicle membrane GO:0030659 cytoplasmic vesicle membrane GO:0030662 coated vesicle membrane GO:0032281 AMPA glutamate receptor complex GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane GO:0034702 ion channel complex GO:0043197 dendritic spine GO:0043198 dendritic shaft GO:0043235 receptor complex GO:0044309 neuron spine GO:0045211 postsynaptic membrane GO:0060076 excitatory synapse GO:0097060 synaptic membrane GO:0098794 postsynapse GO:0098802 plasma membrane receptor complex GO:0098878 neurotransmitter receptor complex GO:0099572 postsynaptic specialization GO:1902495 transmembrane transporter complex GO:1990351 transporter complex |
KEGG | - |
Reactome |
R-HSA-446203: Asparagine N-linked glycosylation R-HSA-204005: COPII (Coat Protein 2) Mediated Vesicle Transport R-HSA-5694530: Cargo concentration in the ER R-HSA-199977: ER to Golgi Anterograde Transport R-HSA-199991: Membrane Trafficking R-HSA-392499: Metabolism of proteins R-HSA-597592: Post-translational protein modification R-HSA-948021: Transport to the Golgi and subsequent modification R-HSA-5653656: Vesicle-mediated transport |
Summary | |
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Symbol | CNIH2 |
Name | cornichon family AMPA receptor auxiliary protein 2 |
Aliases | MGC50896; CNIH-2; cornichon homolog 2 (Drosophila); cornichon homolog 2; Cornichon-like protein; Protein cor ...... |
Chromosomal Location | 11q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between CNIH2 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | CNIH2 |
Name | cornichon family AMPA receptor auxiliary protein 2 |
Aliases | MGC50896; CNIH-2; cornichon homolog 2 (Drosophila); cornichon homolog 2; Cornichon-like protein; Protein cor ...... |
Chromosomal Location | 11q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of CNIH2 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | CNIH2 |
Name | cornichon family AMPA receptor auxiliary protein 2 |
Aliases | MGC50896; CNIH-2; cornichon homolog 2 (Drosophila); cornichon homolog 2; Cornichon-like protein; Protein cor ...... |
Chromosomal Location | 11q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of CNIH2 in various data sets.
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There is no record. |
Summary | |
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Symbol | CNIH2 |
Name | cornichon family AMPA receptor auxiliary protein 2 |
Aliases | MGC50896; CNIH-2; cornichon homolog 2 (Drosophila); cornichon homolog 2; Cornichon-like protein; Protein cor ...... |
Chromosomal Location | 11q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of CNIH2. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | CNIH2 |
Name | cornichon family AMPA receptor auxiliary protein 2 |
Aliases | MGC50896; CNIH-2; cornichon homolog 2 (Drosophila); cornichon homolog 2; Cornichon-like protein; Protein cor ...... |
Chromosomal Location | 11q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of CNIH2. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by CNIH2. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | CNIH2 |
Name | cornichon family AMPA receptor auxiliary protein 2 |
Aliases | MGC50896; CNIH-2; cornichon homolog 2 (Drosophila); cornichon homolog 2; Cornichon-like protein; Protein cor ...... |
Chromosomal Location | 11q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of CNIH2. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | CNIH2 |
Name | cornichon family AMPA receptor auxiliary protein 2 |
Aliases | MGC50896; CNIH-2; cornichon homolog 2 (Drosophila); cornichon homolog 2; Cornichon-like protein; Protein cor ...... |
Chromosomal Location | 11q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of CNIH2 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | CNIH2 |
Name | cornichon family AMPA receptor auxiliary protein 2 |
Aliases | MGC50896; CNIH-2; cornichon homolog 2 (Drosophila); cornichon homolog 2; Cornichon-like protein; Protein cor ...... |
Chromosomal Location | 11q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between CNIH2 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | CNIH2 |
Name | cornichon family AMPA receptor auxiliary protein 2 |
Aliases | MGC50896; CNIH-2; cornichon homolog 2 (Drosophila); cornichon homolog 2; Cornichon-like protein; Protein cor ...... |
Chromosomal Location | 11q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting CNIH2 collected from DrugBank database. |
There is no record. |