Summary | |
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Symbol | CNOT11 |
Name | CCR4-NOT transcription complex, subunit 11 |
Aliases | C40; C2orf29; chromosome 2 open reading frame 29; UPF0760 protein C2orf29; CCR4-NOT transcription complex su ...... |
Chromosomal Location | 2q12.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cytoplasm Nucleus |
Domain |
PF10155 Uncharacterized conserved protein (DUF2363) |
Function |
Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Is required for the association of CNOT10 with the CCR4-NOT complex. Seems not to be required for complex deadenylase function. |
Biological Process |
GO:0000075 cell cycle checkpoint GO:0000077 DNA damage checkpoint GO:0000082 G1/S transition of mitotic cell cycle GO:0000288 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening GO:0000956 nuclear-transcribed mRNA catabolic process GO:0006401 RNA catabolic process GO:0006402 mRNA catabolic process GO:0006417 regulation of translation GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0007050 cell cycle arrest GO:0007093 mitotic cell cycle checkpoint GO:0007346 regulation of mitotic cell cycle GO:0010608 posttranscriptional regulation of gene expression GO:0010948 negative regulation of cell cycle process GO:0016458 gene silencing GO:0019439 aromatic compound catabolic process GO:0030330 DNA damage response, signal transduction by p53 class mediator GO:0031047 gene silencing by RNA GO:0031570 DNA integrity checkpoint GO:0031571 mitotic G1 DNA damage checkpoint GO:0034248 regulation of cellular amide metabolic process GO:0034655 nucleobase-containing compound catabolic process GO:0042770 signal transduction in response to DNA damage GO:0044270 cellular nitrogen compound catabolic process GO:0044770 cell cycle phase transition GO:0044772 mitotic cell cycle phase transition GO:0044773 mitotic DNA damage checkpoint GO:0044774 mitotic DNA integrity checkpoint GO:0044783 G1 DNA damage checkpoint GO:0044819 mitotic G1/S transition checkpoint GO:0044843 cell cycle G1/S phase transition GO:0045786 negative regulation of cell cycle GO:0045787 positive regulation of cell cycle GO:0045930 negative regulation of mitotic cell cycle GO:0046700 heterocycle catabolic process GO:0071156 regulation of cell cycle arrest GO:0071158 positive regulation of cell cycle arrest GO:0072331 signal transduction by p53 class mediator GO:0072395 signal transduction involved in cell cycle checkpoint GO:0072401 signal transduction involved in DNA integrity checkpoint GO:0072413 signal transduction involved in mitotic cell cycle checkpoint GO:0072422 signal transduction involved in DNA damage checkpoint GO:0072431 signal transduction involved in mitotic G1 DNA damage checkpoint GO:0090068 positive regulation of cell cycle process GO:1901361 organic cyclic compound catabolic process GO:1901987 regulation of cell cycle phase transition GO:1901988 negative regulation of cell cycle phase transition GO:1901990 regulation of mitotic cell cycle phase transition GO:1901991 negative regulation of mitotic cell cycle phase transition GO:1902400 intracellular signal transduction involved in G1 DNA damage checkpoint GO:1902402 signal transduction involved in mitotic DNA damage checkpoint GO:1902403 signal transduction involved in mitotic DNA integrity checkpoint GO:1902806 regulation of cell cycle G1/S phase transition GO:1902807 negative regulation of cell cycle G1/S phase transition GO:2000045 regulation of G1/S transition of mitotic cell cycle GO:2000134 negative regulation of G1/S transition of mitotic cell cycle |
Molecular Function | - |
Cellular Component |
GO:0030014 CCR4-NOT complex |
KEGG | - |
Reactome |
R-HSA-429947: Deadenylation of mRNA R-HSA-429914: Deadenylation-dependent mRNA decay R-HSA-74160: Gene Expression R-HSA-212436: Generic Transcription Pathway R-HSA-6791312: TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6804115: TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-3700989: Transcriptional Regulation by TP53 |
Summary | |
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Symbol | CNOT11 |
Name | CCR4-NOT transcription complex, subunit 11 |
Aliases | C40; C2orf29; chromosome 2 open reading frame 29; UPF0760 protein C2orf29; CCR4-NOT transcription complex su ...... |
Chromosomal Location | 2q12.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between CNOT11 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | CNOT11 |
Name | CCR4-NOT transcription complex, subunit 11 |
Aliases | C40; C2orf29; chromosome 2 open reading frame 29; UPF0760 protein C2orf29; CCR4-NOT transcription complex su ...... |
Chromosomal Location | 2q12.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of CNOT11 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | CNOT11 |
Name | CCR4-NOT transcription complex, subunit 11 |
Aliases | C40; C2orf29; chromosome 2 open reading frame 29; UPF0760 protein C2orf29; CCR4-NOT transcription complex su ...... |
Chromosomal Location | 2q12.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of CNOT11 in various data sets.
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There is no record. |
Summary | |
---|---|
Symbol | CNOT11 |
Name | CCR4-NOT transcription complex, subunit 11 |
Aliases | C40; C2orf29; chromosome 2 open reading frame 29; UPF0760 protein C2orf29; CCR4-NOT transcription complex su ...... |
Chromosomal Location | 2q12.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of CNOT11. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | CNOT11 |
Name | CCR4-NOT transcription complex, subunit 11 |
Aliases | C40; C2orf29; chromosome 2 open reading frame 29; UPF0760 protein C2orf29; CCR4-NOT transcription complex su ...... |
Chromosomal Location | 2q12.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of CNOT11. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by CNOT11. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | CNOT11 |
Name | CCR4-NOT transcription complex, subunit 11 |
Aliases | C40; C2orf29; chromosome 2 open reading frame 29; UPF0760 protein C2orf29; CCR4-NOT transcription complex su ...... |
Chromosomal Location | 2q12.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of CNOT11. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | CNOT11 |
Name | CCR4-NOT transcription complex, subunit 11 |
Aliases | C40; C2orf29; chromosome 2 open reading frame 29; UPF0760 protein C2orf29; CCR4-NOT transcription complex su ...... |
Chromosomal Location | 2q12.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of CNOT11 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | CNOT11 |
Name | CCR4-NOT transcription complex, subunit 11 |
Aliases | C40; C2orf29; chromosome 2 open reading frame 29; UPF0760 protein C2orf29; CCR4-NOT transcription complex su ...... |
Chromosomal Location | 2q12.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between CNOT11 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | CNOT11 |
Name | CCR4-NOT transcription complex, subunit 11 |
Aliases | C40; C2orf29; chromosome 2 open reading frame 29; UPF0760 protein C2orf29; CCR4-NOT transcription complex su ...... |
Chromosomal Location | 2q12.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting CNOT11 collected from DrugBank database. |
There is no record. |