Summary | |
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Symbol | CNOT8 |
Name | CCR4-NOT transcription complex, subunit 8 |
Aliases | hCAF1; CALIF; PGK promoter directed over production; CAF1-like protein; CAF2; CALIFp; CCR4-associated factor ...... |
Chromosomal Location | 5q31-q33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cytoplasm Nucleus |
Domain |
PF04857 CAF1 family ribonuclease |
Function |
Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Its function seems to be partially redundant with that of CNOT7. Catalytic component of the CCR4-NOT complex which is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. During miRNA-mediated repression the complex seems also to act as translational repressor during translational initiation. Additional complex functions may be a consequence of its influence on mRNA expression. Associates with members of the BTG family such as TOB1 and BTG2 and is required for their anti-proliferative activity. |
Biological Process |
GO:0000075 cell cycle checkpoint GO:0000077 DNA damage checkpoint GO:0000082 G1/S transition of mitotic cell cycle GO:0000288 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening GO:0000291 nuclear-transcribed mRNA catabolic process, exonucleolytic GO:0000956 nuclear-transcribed mRNA catabolic process GO:0006401 RNA catabolic process GO:0006402 mRNA catabolic process GO:0006417 regulation of translation GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0007050 cell cycle arrest GO:0007093 mitotic cell cycle checkpoint GO:0007346 regulation of mitotic cell cycle GO:0009894 regulation of catabolic process GO:0009896 positive regulation of catabolic process GO:0010608 posttranscriptional regulation of gene expression GO:0010948 negative regulation of cell cycle process GO:0016441 posttranscriptional gene silencing GO:0016458 gene silencing GO:0017148 negative regulation of translation GO:0019439 aromatic compound catabolic process GO:0030330 DNA damage response, signal transduction by p53 class mediator GO:0031047 gene silencing by RNA GO:0031329 regulation of cellular catabolic process GO:0031331 positive regulation of cellular catabolic process GO:0031570 DNA integrity checkpoint GO:0031571 mitotic G1 DNA damage checkpoint GO:0034248 regulation of cellular amide metabolic process GO:0034249 negative regulation of cellular amide metabolic process GO:0034655 nucleobase-containing compound catabolic process GO:0035194 posttranscriptional gene silencing by RNA GO:0035195 gene silencing by miRNA GO:0040029 regulation of gene expression, epigenetic GO:0042770 signal transduction in response to DNA damage GO:0043928 exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay GO:0044270 cellular nitrogen compound catabolic process GO:0044770 cell cycle phase transition GO:0044772 mitotic cell cycle phase transition GO:0044773 mitotic DNA damage checkpoint GO:0044774 mitotic DNA integrity checkpoint GO:0044783 G1 DNA damage checkpoint GO:0044819 mitotic G1/S transition checkpoint GO:0044843 cell cycle G1/S phase transition GO:0045786 negative regulation of cell cycle GO:0045787 positive regulation of cell cycle GO:0045930 negative regulation of mitotic cell cycle GO:0046700 heterocycle catabolic process GO:0061013 regulation of mRNA catabolic process GO:0061014 positive regulation of mRNA catabolic process GO:0071156 regulation of cell cycle arrest GO:0071158 positive regulation of cell cycle arrest GO:0072331 signal transduction by p53 class mediator GO:0072395 signal transduction involved in cell cycle checkpoint GO:0072401 signal transduction involved in DNA integrity checkpoint GO:0072413 signal transduction involved in mitotic cell cycle checkpoint GO:0072422 signal transduction involved in DNA damage checkpoint GO:0072431 signal transduction involved in mitotic G1 DNA damage checkpoint GO:0090068 positive regulation of cell cycle process GO:0090305 nucleic acid phosphodiester bond hydrolysis GO:0090501 RNA phosphodiester bond hydrolysis GO:0090503 RNA phosphodiester bond hydrolysis, exonucleolytic GO:1901361 organic cyclic compound catabolic process GO:1901987 regulation of cell cycle phase transition GO:1901988 negative regulation of cell cycle phase transition GO:1901990 regulation of mitotic cell cycle phase transition GO:1901991 negative regulation of mitotic cell cycle phase transition GO:1902400 intracellular signal transduction involved in G1 DNA damage checkpoint GO:1902402 signal transduction involved in mitotic DNA damage checkpoint GO:1902403 signal transduction involved in mitotic DNA integrity checkpoint GO:1902806 regulation of cell cycle G1/S phase transition GO:1902807 negative regulation of cell cycle G1/S phase transition GO:1903311 regulation of mRNA metabolic process GO:1903313 positive regulation of mRNA metabolic process GO:2000045 regulation of G1/S transition of mitotic cell cycle GO:2000134 negative regulation of G1/S transition of mitotic cell cycle |
Molecular Function |
GO:0000175 3'-5'-exoribonuclease activity GO:0004518 nuclease activity GO:0004527 exonuclease activity GO:0004532 exoribonuclease activity GO:0004535 poly(A)-specific ribonuclease activity GO:0004540 ribonuclease activity GO:0008408 3'-5' exonuclease activity GO:0016796 exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters GO:0016896 exoribonuclease activity, producing 5'-phosphomonoesters |
Cellular Component |
GO:0030014 CCR4-NOT complex |
KEGG |
hsa03018 RNA degradation |
Reactome |
R-HSA-429947: Deadenylation of mRNA R-HSA-429914: Deadenylation-dependent mRNA decay R-HSA-74160: Gene Expression R-HSA-212436: Generic Transcription Pathway R-HSA-6791312: TP53 Regulates Transcription of Cell Cycle Genes R-HSA-6804115: TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain R-HSA-3700989: Transcriptional Regulation by TP53 |
Summary | |
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Symbol | CNOT8 |
Name | CCR4-NOT transcription complex, subunit 8 |
Aliases | hCAF1; CALIF; PGK promoter directed over production; CAF1-like protein; CAF2; CALIFp; CCR4-associated factor ...... |
Chromosomal Location | 5q31-q33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between CNOT8 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between CNOT8 and anti-tumor immunity in human cancer.
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Summary | |
---|---|
Symbol | CNOT8 |
Name | CCR4-NOT transcription complex, subunit 8 |
Aliases | hCAF1; CALIF; PGK promoter directed over production; CAF1-like protein; CAF2; CALIFp; CCR4-associated factor ...... |
Chromosomal Location | 5q31-q33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of CNOT8 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | CNOT8 |
Name | CCR4-NOT transcription complex, subunit 8 |
Aliases | hCAF1; CALIF; PGK promoter directed over production; CAF1-like protein; CAF2; CALIFp; CCR4-associated factor ...... |
Chromosomal Location | 5q31-q33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of CNOT8 in various data sets.
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There is no record. |
Summary | |
---|---|
Symbol | CNOT8 |
Name | CCR4-NOT transcription complex, subunit 8 |
Aliases | hCAF1; CALIF; PGK promoter directed over production; CAF1-like protein; CAF2; CALIFp; CCR4-associated factor ...... |
Chromosomal Location | 5q31-q33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of CNOT8. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | CNOT8 |
Name | CCR4-NOT transcription complex, subunit 8 |
Aliases | hCAF1; CALIF; PGK promoter directed over production; CAF1-like protein; CAF2; CALIFp; CCR4-associated factor ...... |
Chromosomal Location | 5q31-q33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of CNOT8. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by CNOT8. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | CNOT8 |
Name | CCR4-NOT transcription complex, subunit 8 |
Aliases | hCAF1; CALIF; PGK promoter directed over production; CAF1-like protein; CAF2; CALIFp; CCR4-associated factor ...... |
Chromosomal Location | 5q31-q33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of CNOT8. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | CNOT8 |
Name | CCR4-NOT transcription complex, subunit 8 |
Aliases | hCAF1; CALIF; PGK promoter directed over production; CAF1-like protein; CAF2; CALIFp; CCR4-associated factor ...... |
Chromosomal Location | 5q31-q33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of CNOT8 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | CNOT8 |
Name | CCR4-NOT transcription complex, subunit 8 |
Aliases | hCAF1; CALIF; PGK promoter directed over production; CAF1-like protein; CAF2; CALIFp; CCR4-associated factor ...... |
Chromosomal Location | 5q31-q33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between CNOT8 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | CNOT8 |
Name | CCR4-NOT transcription complex, subunit 8 |
Aliases | hCAF1; CALIF; PGK promoter directed over production; CAF1-like protein; CAF2; CALIFp; CCR4-associated factor ...... |
Chromosomal Location | 5q31-q33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting CNOT8 collected from DrugBank database. |
There is no record. |