Summary | |
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Symbol | CNTN6 |
Name | contactin 6 |
Aliases | NB-3; NB3; neural recognition molecule NB-3; hNB-3; Contactin-6 |
Chromosomal Location | 3p26.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cell membrane Lipid-anchor, GPI-anchor |
Domain |
PF00041 Fibronectin type III domain PF07679 Immunoglobulin I-set domain |
Function |
Contactins mediate cell surface interactions during nervous system development. Participates in oligodendrocytes generation by acting as a ligand of NOTCH1. Its association with NOTCH1 promotes NOTCH1 activation through the released notch intracellular domain (NICD) and subsequent translocation to the nucleus. Involved in motor coordination (By similarity). |
Biological Process |
GO:0007219 Notch signaling pathway |
Molecular Function |
GO:0005112 Notch binding |
Cellular Component |
GO:0031225 anchored component of membrane |
KEGG | - |
Reactome |
R-HSA-422475: Axon guidance R-HSA-447041: CHL1 interactions R-HSA-1266738: Developmental Biology R-HSA-373760: L1CAM interactions |
Summary | |
---|---|
Symbol | CNTN6 |
Name | contactin 6 |
Aliases | NB-3; NB3; neural recognition molecule NB-3; hNB-3; Contactin-6 |
Chromosomal Location | 3p26.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between CNTN6 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | CNTN6 |
Name | contactin 6 |
Aliases | NB-3; NB3; neural recognition molecule NB-3; hNB-3; Contactin-6 |
Chromosomal Location | 3p26.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of CNTN6 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | CNTN6 |
Name | contactin 6 |
Aliases | NB-3; NB3; neural recognition molecule NB-3; hNB-3; Contactin-6 |
Chromosomal Location | 3p26.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of CNTN6 in various data sets.
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Points in the above scatter plot represent the mutation difference of CNTN6 in various data sets.
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Summary | |
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Symbol | CNTN6 |
Name | contactin 6 |
Aliases | NB-3; NB3; neural recognition molecule NB-3; hNB-3; Contactin-6 |
Chromosomal Location | 3p26.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of CNTN6. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | CNTN6 |
Name | contactin 6 |
Aliases | NB-3; NB3; neural recognition molecule NB-3; hNB-3; Contactin-6 |
Chromosomal Location | 3p26.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of CNTN6. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by CNTN6. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | CNTN6 |
Name | contactin 6 |
Aliases | NB-3; NB3; neural recognition molecule NB-3; hNB-3; Contactin-6 |
Chromosomal Location | 3p26.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of CNTN6. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | CNTN6 |
Name | contactin 6 |
Aliases | NB-3; NB3; neural recognition molecule NB-3; hNB-3; Contactin-6 |
Chromosomal Location | 3p26.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of CNTN6 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | CNTN6 |
Name | contactin 6 |
Aliases | NB-3; NB3; neural recognition molecule NB-3; hNB-3; Contactin-6 |
Chromosomal Location | 3p26.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between CNTN6 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |