Summary | |
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Symbol | COCH |
Name | cochlin |
Aliases | COCH-5B2; DFNA9; coagulation factor C (Limulus polyphemus homolog); cochlin; coagulation factor C homolog, c ...... |
Chromosomal Location | 14q11.2-q13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Secreted, extracellular space, extracellular matrix |
Domain |
PF03815 LCCL domain PF00092 von Willebrand factor type A domain |
Function |
Plays a role in the control of cell shape and motility in the trabecular meshwork. |
Biological Process |
GO:0007605 sensory perception of sound GO:0008360 regulation of cell shape GO:0022604 regulation of cell morphogenesis GO:0031349 positive regulation of defense response GO:0042742 defense response to bacterium GO:0045088 regulation of innate immune response GO:0045089 positive regulation of innate immune response GO:0050954 sensory perception of mechanical stimulus GO:0098542 defense response to other organism |
Molecular Function |
GO:0005518 collagen binding |
Cellular Component |
GO:0005578 proteinaceous extracellular matrix |
KEGG | - |
Reactome | - |
Summary | |
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Symbol | COCH |
Name | cochlin |
Aliases | COCH-5B2; DFNA9; coagulation factor C (Limulus polyphemus homolog); cochlin; coagulation factor C homolog, c ...... |
Chromosomal Location | 14q11.2-q13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between COCH and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | COCH |
Name | cochlin |
Aliases | COCH-5B2; DFNA9; coagulation factor C (Limulus polyphemus homolog); cochlin; coagulation factor C homolog, c ...... |
Chromosomal Location | 14q11.2-q13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of COCH in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | COCH |
Name | cochlin |
Aliases | COCH-5B2; DFNA9; coagulation factor C (Limulus polyphemus homolog); cochlin; coagulation factor C homolog, c ...... |
Chromosomal Location | 14q11.2-q13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of COCH in various data sets.
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Points in the above scatter plot represent the mutation difference of COCH in various data sets.
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Summary | |
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Symbol | COCH |
Name | cochlin |
Aliases | COCH-5B2; DFNA9; coagulation factor C (Limulus polyphemus homolog); cochlin; coagulation factor C homolog, c ...... |
Chromosomal Location | 14q11.2-q13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of COCH. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | COCH |
Name | cochlin |
Aliases | COCH-5B2; DFNA9; coagulation factor C (Limulus polyphemus homolog); cochlin; coagulation factor C homolog, c ...... |
Chromosomal Location | 14q11.2-q13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of COCH. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by COCH. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | COCH |
Name | cochlin |
Aliases | COCH-5B2; DFNA9; coagulation factor C (Limulus polyphemus homolog); cochlin; coagulation factor C homolog, c ...... |
Chromosomal Location | 14q11.2-q13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of COCH. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | COCH |
Name | cochlin |
Aliases | COCH-5B2; DFNA9; coagulation factor C (Limulus polyphemus homolog); cochlin; coagulation factor C homolog, c ...... |
Chromosomal Location | 14q11.2-q13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of COCH expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | COCH |
Name | cochlin |
Aliases | COCH-5B2; DFNA9; coagulation factor C (Limulus polyphemus homolog); cochlin; coagulation factor C homolog, c ...... |
Chromosomal Location | 14q11.2-q13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between COCH and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | COCH |
Name | cochlin |
Aliases | COCH-5B2; DFNA9; coagulation factor C (Limulus polyphemus homolog); cochlin; coagulation factor C homolog, c ...... |
Chromosomal Location | 14q11.2-q13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting COCH collected from DrugBank database. |
There is no record. |