Summary | |
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Symbol | COG8 |
Name | component of oligomeric golgi complex 8 |
Aliases | FLJ22315; DOR1; CDG2H; COG complex subunit 8; conserved oligomeric golgi complex component 8; dependent on R ...... |
Chromosomal Location | 16q22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Golgi apparatus membrane Peripheral membrane protein |
Domain |
PF04124 Dor1-like family |
Function |
Required for normal Golgi function. |
Biological Process |
GO:0006888 ER to Golgi vesicle-mediated transport GO:0006891 intra-Golgi vesicle-mediated transport GO:0048193 Golgi vesicle transport |
Molecular Function | - |
Cellular Component |
GO:0005802 trans-Golgi network GO:0017119 Golgi transport complex GO:0031984 organelle subcompartment GO:0032588 trans-Golgi network membrane GO:0098791 Golgi subcompartment GO:0099023 tethring complex |
KEGG | - |
Reactome |
R-HSA-446203: Asparagine N-linked glycosylation R-HSA-6807878: COPI-mediated anterograde transport R-HSA-199977: ER to Golgi Anterograde Transport R-HSA-6811442: Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811438: Intra-Golgi traffic R-HSA-199991: Membrane Trafficking R-HSA-392499: Metabolism of proteins R-HSA-597592: Post-translational protein modification R-HSA-6811440: Retrograde transport at the Trans-Golgi-Network R-HSA-948021: Transport to the Golgi and subsequent modification R-HSA-5653656: Vesicle-mediated transport |
Summary | |
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Symbol | COG8 |
Name | component of oligomeric golgi complex 8 |
Aliases | FLJ22315; DOR1; CDG2H; COG complex subunit 8; conserved oligomeric golgi complex component 8; dependent on R ...... |
Chromosomal Location | 16q22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between COG8 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | COG8 |
Name | component of oligomeric golgi complex 8 |
Aliases | FLJ22315; DOR1; CDG2H; COG complex subunit 8; conserved oligomeric golgi complex component 8; dependent on R ...... |
Chromosomal Location | 16q22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of COG8 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | COG8 |
Name | component of oligomeric golgi complex 8 |
Aliases | FLJ22315; DOR1; CDG2H; COG complex subunit 8; conserved oligomeric golgi complex component 8; dependent on R ...... |
Chromosomal Location | 16q22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of COG8 in various data sets.
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Points in the above scatter plot represent the mutation difference of COG8 in various data sets.
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Summary | |
---|---|
Symbol | COG8 |
Name | component of oligomeric golgi complex 8 |
Aliases | FLJ22315; DOR1; CDG2H; COG complex subunit 8; conserved oligomeric golgi complex component 8; dependent on R ...... |
Chromosomal Location | 16q22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of COG8. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | COG8 |
Name | component of oligomeric golgi complex 8 |
Aliases | FLJ22315; DOR1; CDG2H; COG complex subunit 8; conserved oligomeric golgi complex component 8; dependent on R ...... |
Chromosomal Location | 16q22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of COG8. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by COG8. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | COG8 |
Name | component of oligomeric golgi complex 8 |
Aliases | FLJ22315; DOR1; CDG2H; COG complex subunit 8; conserved oligomeric golgi complex component 8; dependent on R ...... |
Chromosomal Location | 16q22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of COG8. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | COG8 |
Name | component of oligomeric golgi complex 8 |
Aliases | FLJ22315; DOR1; CDG2H; COG complex subunit 8; conserved oligomeric golgi complex component 8; dependent on R ...... |
Chromosomal Location | 16q22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of COG8 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | COG8 |
Name | component of oligomeric golgi complex 8 |
Aliases | FLJ22315; DOR1; CDG2H; COG complex subunit 8; conserved oligomeric golgi complex component 8; dependent on R ...... |
Chromosomal Location | 16q22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between COG8 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | COG8 |
Name | component of oligomeric golgi complex 8 |
Aliases | FLJ22315; DOR1; CDG2H; COG complex subunit 8; conserved oligomeric golgi complex component 8; dependent on R ...... |
Chromosomal Location | 16q22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting COG8 collected from DrugBank database. |
There is no record. |