Summary | |
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Symbol | COL10A1 |
Name | collagen, type X, alpha 1 |
Aliases | Schmid metaphyseal chondrodysplasia; collagen X, alpha-1 polypeptide; Collagen alpha-1(X) chain |
Chromosomal Location | 6q21-q22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Secreted, extracellular space, extracellular matrix |
Domain |
PF00386 C1q domain PF01391 Collagen triple helix repeat (20 copies) |
Function |
Type X collagen is a product of hypertrophic chondrocytes and has been localized to presumptive mineralization zones of hyaline cartilage. |
Biological Process |
GO:0001501 skeletal system development GO:0001503 ossification GO:0001958 endochondral ossification GO:0030198 extracellular matrix organization GO:0030574 collagen catabolic process GO:0032963 collagen metabolic process GO:0036075 replacement ossification GO:0043062 extracellular structure organization GO:0044236 multicellular organism metabolic process GO:0044243 multicellular organism catabolic process GO:0044259 multicellular organismal macromolecule metabolic process GO:0048705 skeletal system morphogenesis GO:0051216 cartilage development GO:0060348 bone development GO:0060349 bone morphogenesis GO:0060350 endochondral bone morphogenesis GO:0061448 connective tissue development |
Molecular Function | - |
Cellular Component |
GO:0005578 proteinaceous extracellular matrix GO:0005581 collagen trimer GO:0005788 endoplasmic reticulum lumen GO:0005938 cell cortex GO:0099568 cytoplasmic region |
KEGG |
hsa04974 Protein digestion and absorption |
Reactome |
R-HSA-2022090: Assembly of collagen fibrils and other multimeric structures R-HSA-1650814: Collagen biosynthesis and modifying enzymes R-HSA-8948216: Collagen chain trimerization R-HSA-1474290: Collagen formation R-HSA-1474244: Extracellular matrix organization |
Summary | |
---|---|
Symbol | COL10A1 |
Name | collagen, type X, alpha 1 |
Aliases | Schmid metaphyseal chondrodysplasia; collagen X, alpha-1 polypeptide; Collagen alpha-1(X) chain |
Chromosomal Location | 6q21-q22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between COL10A1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | COL10A1 |
Name | collagen, type X, alpha 1 |
Aliases | Schmid metaphyseal chondrodysplasia; collagen X, alpha-1 polypeptide; Collagen alpha-1(X) chain |
Chromosomal Location | 6q21-q22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of COL10A1 in screening data sets for detecting immune reponses.
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Summary | |
---|---|
Symbol | COL10A1 |
Name | collagen, type X, alpha 1 |
Aliases | Schmid metaphyseal chondrodysplasia; collagen X, alpha-1 polypeptide; Collagen alpha-1(X) chain |
Chromosomal Location | 6q21-q22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of COL10A1 in various data sets.
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Points in the above scatter plot represent the mutation difference of COL10A1 in various data sets.
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Summary | |
---|---|
Symbol | COL10A1 |
Name | collagen, type X, alpha 1 |
Aliases | Schmid metaphyseal chondrodysplasia; collagen X, alpha-1 polypeptide; Collagen alpha-1(X) chain |
Chromosomal Location | 6q21-q22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of COL10A1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | COL10A1 |
Name | collagen, type X, alpha 1 |
Aliases | Schmid metaphyseal chondrodysplasia; collagen X, alpha-1 polypeptide; Collagen alpha-1(X) chain |
Chromosomal Location | 6q21-q22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of COL10A1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by COL10A1. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | COL10A1 |
Name | collagen, type X, alpha 1 |
Aliases | Schmid metaphyseal chondrodysplasia; collagen X, alpha-1 polypeptide; Collagen alpha-1(X) chain |
Chromosomal Location | 6q21-q22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of COL10A1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | COL10A1 |
Name | collagen, type X, alpha 1 |
Aliases | Schmid metaphyseal chondrodysplasia; collagen X, alpha-1 polypeptide; Collagen alpha-1(X) chain |
Chromosomal Location | 6q21-q22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of COL10A1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | COL10A1 |
Name | collagen, type X, alpha 1 |
Aliases | Schmid metaphyseal chondrodysplasia; collagen X, alpha-1 polypeptide; Collagen alpha-1(X) chain |
Chromosomal Location | 6q21-q22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between COL10A1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | COL10A1 |
Name | collagen, type X, alpha 1 |
Aliases | Schmid metaphyseal chondrodysplasia; collagen X, alpha-1 polypeptide; Collagen alpha-1(X) chain |
Chromosomal Location | 6q21-q22 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting COL10A1 collected from DrugBank database. |
There is no record. |