Browse COL12A1

Summary
SymbolCOL12A1
Namecollagen, type XII, alpha 1
Aliases collagen type XII proteoglycan; COL12A1L; collagen, type XII, alpha 1-like; BA209D8.1L; DJ234P15.1; Collagen ......
Chromosomal Location6q12-q13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Secreted, extracellular space, extracellular matrix
Domain PF01391 Collagen triple helix repeat (20 copies)
PF00041 Fibronectin type III domain
PF00092 von Willebrand factor type A domain
Function

Type XII collagen interacts with type I collagen-containing fibrils, the COL1 domain could be associated with the surface of the fibrils, and the COL2 and NC3 domains may be localized in the perifibrillar matrix.

> Gene Ontology
 
Biological Process GO:0001501 skeletal system development
GO:0001704 formation of primary germ layer
GO:0001706 endoderm formation
GO:0007369 gastrulation
GO:0007492 endoderm development
GO:0030198 extracellular matrix organization
GO:0030199 collagen fibril organization
GO:0030574 collagen catabolic process
GO:0032963 collagen metabolic process
GO:0035987 endodermal cell differentiation
GO:0043062 extracellular structure organization
GO:0044236 multicellular organism metabolic process
GO:0044243 multicellular organism catabolic process
GO:0044259 multicellular organismal macromolecule metabolic process
Molecular Function GO:0005201 extracellular matrix structural constituent
GO:0030020 extracellular matrix structural constituent conferring tensile strength
Cellular Component GO:0005578 proteinaceous extracellular matrix
GO:0005581 collagen trimer
GO:0005593 FACIT collagen trimer
GO:0005595 collagen type XII trimer
GO:0005788 endoplasmic reticulum lumen
GO:0030934 anchoring collagen complex
GO:0044420 extracellular matrix component
> KEGG and Reactome Pathway
 
KEGG hsa04974 Protein digestion and absorption
Reactome R-HSA-1650814: Collagen biosynthesis and modifying enzymes
R-HSA-8948216: Collagen chain trimerization
R-HSA-1442490: Collagen degradation
R-HSA-1474290: Collagen formation
R-HSA-1474228: Degradation of the extracellular matrix
R-HSA-1474244: Extracellular matrix organization
Summary
SymbolCOL12A1
Namecollagen, type XII, alpha 1
Aliases collagen type XII proteoglycan; COL12A1L; collagen, type XII, alpha 1-like; BA209D8.1L; DJ234P15.1; Collagen ......
Chromosomal Location6q12-q13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between COL12A1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.

Summary
SymbolCOL12A1
Namecollagen, type XII, alpha 1
Aliases collagen type XII proteoglycan; COL12A1L; collagen, type XII, alpha 1-like; BA209D8.1L; DJ234P15.1; Collagen ......
Chromosomal Location6q12-q13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of COL12A1 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolCOL12A1
Namecollagen, type XII, alpha 1
Aliases collagen type XII proteoglycan; COL12A1L; collagen, type XII, alpha 1-like; BA209D8.1L; DJ234P15.1; Collagen ......
Chromosomal Location6q12-q13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of COL12A1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-1.6240.0241
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-1.8650.352
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-1.4380.314
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.8560.113
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-1.5430.591
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.0210.996
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.3770.59
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.1240.946
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.6120.768
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.2660.876
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 282.3930.253
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.0270.896
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of COL12A1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 277318.58.210.30.161
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 01407.1-7.11
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 275918.58.5100.275
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)211723.829.4-5.60.727
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)8637.516.720.80.58
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)131115.436.4-210.357
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91611.16.24.91
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59011.1-11.11
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47250250.364
1329033130MelanomaallAnti-PD-1 (nivolumab) 382721.111.1100.338
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 221327.37.719.60.22
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 161412.514.3-1.81
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 111307.7-7.71
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 51208.3-8.31
Summary
SymbolCOL12A1
Namecollagen, type XII, alpha 1
Aliases collagen type XII proteoglycan; COL12A1L; collagen, type XII, alpha 1-like; BA209D8.1L; DJ234P15.1; Collagen ......
Chromosomal Location6q12-q13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of COL12A1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolCOL12A1
Namecollagen, type XII, alpha 1
Aliases collagen type XII proteoglycan; COL12A1L; collagen, type XII, alpha 1-like; BA209D8.1L; DJ234P15.1; Collagen ......
Chromosomal Location6q12-q13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of COL12A1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by COL12A1.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolCOL12A1
Namecollagen, type XII, alpha 1
Aliases collagen type XII proteoglycan; COL12A1L; collagen, type XII, alpha 1-like; BA209D8.1L; DJ234P15.1; Collagen ......
Chromosomal Location6q12-q13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of COL12A1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolCOL12A1
Namecollagen, type XII, alpha 1
Aliases collagen type XII proteoglycan; COL12A1L; collagen, type XII, alpha 1-like; BA209D8.1L; DJ234P15.1; Collagen ......
Chromosomal Location6q12-q13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of COL12A1 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolCOL12A1
Namecollagen, type XII, alpha 1
Aliases collagen type XII proteoglycan; COL12A1L; collagen, type XII, alpha 1-like; BA209D8.1L; DJ234P15.1; Collagen ......
Chromosomal Location6q12-q13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between COL12A1 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolCOL12A1
Namecollagen, type XII, alpha 1
Aliases collagen type XII proteoglycan; COL12A1L; collagen, type XII, alpha 1-like; BA209D8.1L; DJ234P15.1; Collagen ......
Chromosomal Location6q12-q13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting COL12A1 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.