Summary | |
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Symbol | COL1A2 |
Name | collagen, type I, alpha 2 |
Aliases | alpha 2(I)-collagen; alpha-2 collagen type I; type I procollagen; collagen I, alpha-2 polypeptide; collagen ...... |
Chromosomal Location | 7q21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Secreted, extracellular space, extracellular matrix |
Domain |
PF01410 Fibrillar collagen C-terminal domain PF01391 Collagen triple helix repeat (20 copies) |
Function |
Type I collagen is a member of group I collagen (fibrillar forming collagen). |
Biological Process |
GO:0001101 response to acid chemical GO:0001501 skeletal system development GO:0003013 circulatory system process GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007179 transforming growth factor beta receptor signaling pathway GO:0007265 Ras protein signal transduction GO:0007266 Rho protein signal transduction GO:0007596 blood coagulation GO:0007599 hemostasis GO:0008015 blood circulation GO:0008217 regulation of blood pressure GO:0030168 platelet activation GO:0030198 extracellular matrix organization GO:0030199 collagen fibril organization GO:0030574 collagen catabolic process GO:0032963 collagen metabolic process GO:0042476 odontogenesis GO:0043062 extracellular structure organization GO:0043200 response to amino acid GO:0043588 skin development GO:0043589 skin morphogenesis GO:0044236 multicellular organism metabolic process GO:0044243 multicellular organism catabolic process GO:0044259 multicellular organismal macromolecule metabolic process GO:0050817 coagulation GO:0050878 regulation of body fluid levels GO:0050900 leukocyte migration GO:0051259 protein oligomerization GO:0051291 protein heterooligomerization GO:0070206 protein trimerization GO:0070208 protein heterotrimerization GO:0071229 cellular response to acid chemical GO:0071230 cellular response to amino acid stimulus GO:0071417 cellular response to organonitrogen compound GO:0071559 response to transforming growth factor beta GO:0071560 cellular response to transforming growth factor beta stimulus |
Molecular Function |
GO:0005201 extracellular matrix structural constituent GO:0019838 growth factor binding GO:0030674 protein binding, bridging GO:0046332 SMAD binding GO:0048407 platelet-derived growth factor binding GO:0060090 binding, bridging |
Cellular Component |
GO:0005578 proteinaceous extracellular matrix GO:0005581 collagen trimer GO:0005583 fibrillar collagen trimer GO:0005584 collagen type I trimer GO:0005788 endoplasmic reticulum lumen GO:0044420 extracellular matrix component GO:0098643 banded collagen fibril GO:0098644 complex of collagen trimers |
KEGG |
hsa04151 PI3K-Akt signaling pathway hsa04510 Focal adhesion hsa04512 ECM-receptor interaction hsa04611 Platelet activation hsa04974 Protein digestion and absorption |
Reactome |
R-HSA-2022090: Assembly of collagen fibrils and other multimeric structures R-HSA-2173782: Binding and Uptake of Ligands by Scavenger Receptors R-HSA-1650814: Collagen biosynthesis and modifying enzymes R-HSA-8948216: Collagen chain trimerization R-HSA-1474290: Collagen formation R-HSA-1280215: Cytokine Signaling in Immune system R-HSA-1474244: Extracellular matrix organization R-HSA-168256: Immune System R-HSA-6785807: Interleukin-4 and 13 signaling R-HSA-3000480: Scavenging by Class A Receptors R-HSA-449147: Signaling by Interleukins R-HSA-5653656: Vesicle-mediated transport |
Summary | |
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Symbol | COL1A2 |
Name | collagen, type I, alpha 2 |
Aliases | alpha 2(I)-collagen; alpha-2 collagen type I; type I procollagen; collagen I, alpha-2 polypeptide; collagen ...... |
Chromosomal Location | 7q21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between COL1A2 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
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Symbol | COL1A2 |
Name | collagen, type I, alpha 2 |
Aliases | alpha 2(I)-collagen; alpha-2 collagen type I; type I procollagen; collagen I, alpha-2 polypeptide; collagen ...... |
Chromosomal Location | 7q21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of COL1A2 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | COL1A2 |
Name | collagen, type I, alpha 2 |
Aliases | alpha 2(I)-collagen; alpha-2 collagen type I; type I procollagen; collagen I, alpha-2 polypeptide; collagen ...... |
Chromosomal Location | 7q21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of COL1A2 in various data sets.
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Points in the above scatter plot represent the mutation difference of COL1A2 in various data sets.
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Summary | |
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Symbol | COL1A2 |
Name | collagen, type I, alpha 2 |
Aliases | alpha 2(I)-collagen; alpha-2 collagen type I; type I procollagen; collagen I, alpha-2 polypeptide; collagen ...... |
Chromosomal Location | 7q21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of COL1A2. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | COL1A2 |
Name | collagen, type I, alpha 2 |
Aliases | alpha 2(I)-collagen; alpha-2 collagen type I; type I procollagen; collagen I, alpha-2 polypeptide; collagen ...... |
Chromosomal Location | 7q21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of COL1A2. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by COL1A2. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | COL1A2 |
Name | collagen, type I, alpha 2 |
Aliases | alpha 2(I)-collagen; alpha-2 collagen type I; type I procollagen; collagen I, alpha-2 polypeptide; collagen ...... |
Chromosomal Location | 7q21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of COL1A2. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | COL1A2 |
Name | collagen, type I, alpha 2 |
Aliases | alpha 2(I)-collagen; alpha-2 collagen type I; type I procollagen; collagen I, alpha-2 polypeptide; collagen ...... |
Chromosomal Location | 7q21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of COL1A2 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | COL1A2 |
Name | collagen, type I, alpha 2 |
Aliases | alpha 2(I)-collagen; alpha-2 collagen type I; type I procollagen; collagen I, alpha-2 polypeptide; collagen ...... |
Chromosomal Location | 7q21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between COL1A2 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | COL1A2 |
Name | collagen, type I, alpha 2 |
Aliases | alpha 2(I)-collagen; alpha-2 collagen type I; type I procollagen; collagen I, alpha-2 polypeptide; collagen ...... |
Chromosomal Location | 7q21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting COL1A2 collected from DrugBank database. |
Details on drugs targeting COL1A2.
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