Summary | |
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Symbol | COL3A1 |
Name | collagen, type III, alpha 1 |
Aliases | EDS4A; Ehlers-Danlos syndrome type IV, autosomal dominant; alpha1 (III) collagen; collagen, fetal; Collagen ...... |
Chromosomal Location | 2q32.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Secreted, extracellular space, extracellular matrix |
Domain |
PF01410 Fibrillar collagen C-terminal domain PF01391 Collagen triple helix repeat (20 copies) PF00093 von Willebrand factor type C domain |
Function |
Collagen type III occurs in most soft connective tissues along with type I collagen. Involved in regulation of cortical development. Is the major ligand of ADGRG1 in the developing brain and binding to ADGRG1 inhibits neuronal migration and activates the RhoA pathway by coupling ADGRG1 to GNA13 and possibly GNA12. |
Biological Process |
GO:0001101 response to acid chemical GO:0001501 skeletal system development GO:0001764 neuron migration GO:0002683 negative regulation of immune system process GO:0007160 cell-matrix adhesion GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007179 transforming growth factor beta receptor signaling pathway GO:0007229 integrin-mediated signaling pathway GO:0007265 Ras protein signal transduction GO:0007266 Rho protein signal transduction GO:0007507 heart development GO:0007517 muscle organ development GO:0007568 aging GO:0007596 blood coagulation GO:0007599 hemostasis GO:0009314 response to radiation GO:0009612 response to mechanical stimulus GO:0010721 negative regulation of cell development GO:0018149 peptide cross-linking GO:0021537 telencephalon development GO:0021543 pallium development GO:0021987 cerebral cortex development GO:0030168 platelet activation GO:0030198 extracellular matrix organization GO:0030199 collagen fibril organization GO:0030336 negative regulation of cell migration GO:0030574 collagen catabolic process GO:0030900 forebrain development GO:0031589 cell-substrate adhesion GO:0032963 collagen metabolic process GO:0035023 regulation of Rho protein signal transduction GO:0035025 positive regulation of Rho protein signal transduction GO:0035904 aorta development GO:0035909 aorta morphogenesis GO:0040013 negative regulation of locomotion GO:0043062 extracellular structure organization GO:0043200 response to amino acid GO:0043206 extracellular fibril organization GO:0043588 skin development GO:0044236 multicellular organism metabolic process GO:0044243 multicellular organism catabolic process GO:0044259 multicellular organismal macromolecule metabolic process GO:0046578 regulation of Ras protein signal transduction GO:0046579 positive regulation of Ras protein signal transduction GO:0048514 blood vessel morphogenesis GO:0048565 digestive tract development GO:0048644 muscle organ morphogenesis GO:0048745 smooth muscle tissue development GO:0048844 artery morphogenesis GO:0050768 negative regulation of neurogenesis GO:0050777 negative regulation of immune response GO:0050817 coagulation GO:0050878 regulation of body fluid levels GO:0051056 regulation of small GTPase mediated signal transduction GO:0051057 positive regulation of small GTPase mediated signal transduction GO:0051271 negative regulation of cellular component movement GO:0051961 negative regulation of nervous system development GO:0055123 digestive system development GO:0060414 aorta smooth muscle tissue morphogenesis GO:0060415 muscle tissue morphogenesis GO:0060537 muscle tissue development GO:0060840 artery development GO:0071229 cellular response to acid chemical GO:0071230 cellular response to amino acid stimulus GO:0071417 cellular response to organonitrogen compound GO:0071559 response to transforming growth factor beta GO:0071560 cellular response to transforming growth factor beta stimulus GO:0097435 fibril organization GO:2000146 negative regulation of cell motility GO:2001222 regulation of neuron migration GO:2001223 negative regulation of neuron migration |
Molecular Function |
GO:0005178 integrin binding GO:0005201 extracellular matrix structural constituent GO:0019838 growth factor binding GO:0046332 SMAD binding GO:0048407 platelet-derived growth factor binding GO:0050839 cell adhesion molecule binding |
Cellular Component |
GO:0005578 proteinaceous extracellular matrix GO:0005581 collagen trimer GO:0005583 fibrillar collagen trimer GO:0005586 collagen type III trimer GO:0005788 endoplasmic reticulum lumen GO:0044420 extracellular matrix component GO:0098643 banded collagen fibril GO:0098644 complex of collagen trimers |
KEGG |
hsa04611 Platelet activation hsa04974 Protein digestion and absorption |
Reactome |
R-HSA-2022090: Assembly of collagen fibrils and other multimeric structures R-HSA-2173782: Binding and Uptake of Ligands by Scavenger Receptors R-HSA-1650814: Collagen biosynthesis and modifying enzymes R-HSA-8948216: Collagen chain trimerization R-HSA-1474290: Collagen formation R-HSA-1474244: Extracellular matrix organization R-HSA-3000480: Scavenging by Class A Receptors R-HSA-5653656: Vesicle-mediated transport |
Summary | |
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Symbol | COL3A1 |
Name | collagen, type III, alpha 1 |
Aliases | EDS4A; Ehlers-Danlos syndrome type IV, autosomal dominant; alpha1 (III) collagen; collagen, fetal; Collagen ...... |
Chromosomal Location | 2q32.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between COL3A1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
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Symbol | COL3A1 |
Name | collagen, type III, alpha 1 |
Aliases | EDS4A; Ehlers-Danlos syndrome type IV, autosomal dominant; alpha1 (III) collagen; collagen, fetal; Collagen ...... |
Chromosomal Location | 2q32.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of COL3A1 in screening data sets for detecting immune reponses.
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Summary | |
---|---|
Symbol | COL3A1 |
Name | collagen, type III, alpha 1 |
Aliases | EDS4A; Ehlers-Danlos syndrome type IV, autosomal dominant; alpha1 (III) collagen; collagen, fetal; Collagen ...... |
Chromosomal Location | 2q32.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of COL3A1 in various data sets.
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Points in the above scatter plot represent the mutation difference of COL3A1 in various data sets.
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Summary | |
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Symbol | COL3A1 |
Name | collagen, type III, alpha 1 |
Aliases | EDS4A; Ehlers-Danlos syndrome type IV, autosomal dominant; alpha1 (III) collagen; collagen, fetal; Collagen ...... |
Chromosomal Location | 2q32.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of COL3A1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | COL3A1 |
Name | collagen, type III, alpha 1 |
Aliases | EDS4A; Ehlers-Danlos syndrome type IV, autosomal dominant; alpha1 (III) collagen; collagen, fetal; Collagen ...... |
Chromosomal Location | 2q32.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of COL3A1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by COL3A1. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | COL3A1 |
Name | collagen, type III, alpha 1 |
Aliases | EDS4A; Ehlers-Danlos syndrome type IV, autosomal dominant; alpha1 (III) collagen; collagen, fetal; Collagen ...... |
Chromosomal Location | 2q32.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of COL3A1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | COL3A1 |
Name | collagen, type III, alpha 1 |
Aliases | EDS4A; Ehlers-Danlos syndrome type IV, autosomal dominant; alpha1 (III) collagen; collagen, fetal; Collagen ...... |
Chromosomal Location | 2q32.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of COL3A1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | COL3A1 |
Name | collagen, type III, alpha 1 |
Aliases | EDS4A; Ehlers-Danlos syndrome type IV, autosomal dominant; alpha1 (III) collagen; collagen, fetal; Collagen ...... |
Chromosomal Location | 2q32.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between COL3A1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | COL3A1 |
Name | collagen, type III, alpha 1 |
Aliases | EDS4A; Ehlers-Danlos syndrome type IV, autosomal dominant; alpha1 (III) collagen; collagen, fetal; Collagen ...... |
Chromosomal Location | 2q32.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting COL3A1 collected from DrugBank database. |
Details on drugs targeting COL3A1.
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