Browse COL4A1

Summary
SymbolCOL4A1
Namecollagen, type IV, alpha 1
Aliases BSVD; RATOR; COL4A1 NC1 domain; arresten; collagen IV, alpha-1 polypeptide; collagen of basement membrane, a ......
Chromosomal Location13q34
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Secreted, extracellular space, extracellular matrix, basement membrane
Domain PF01413 C-terminal tandem repeated domain in type 4 procollagen
PF01391 Collagen triple helix repeat (20 copies)
Function

Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen. ; FUNCTION: Arresten, comprising the C-terminal NC1 domain, inhibits angiogenesis and tumor formation. The C-terminal half is found to possess the anti-angiogenic activity. Specifically inhibits endothelial cell proliferation, migration and tube formation. Inhibits expression of hypoxia-inducible factor 1alpha and ERK1/2 and p38 MAPK activation. Ligand for alpha1/beta1 integrin.

> Gene Ontology
 
Biological Process GO:0001101 response to acid chemical
GO:0001525 angiogenesis
GO:0001569 patterning of blood vessels
GO:0001654 eye development
GO:0001655 urogenital system development
GO:0001763 morphogenesis of a branching structure
GO:0007389 pattern specification process
GO:0007423 sensory organ development
GO:0007528 neuromuscular junction development
GO:0030198 extracellular matrix organization
GO:0030574 collagen catabolic process
GO:0032963 collagen metabolic process
GO:0035239 tube morphogenesis
GO:0043010 camera-type eye development
GO:0043062 extracellular structure organization
GO:0043200 response to amino acid
GO:0044236 multicellular organism metabolic process
GO:0044243 multicellular organism catabolic process
GO:0044259 multicellular organismal macromolecule metabolic process
GO:0048514 blood vessel morphogenesis
GO:0048754 branching morphogenesis of an epithelial tube
GO:0050808 synapse organization
GO:0060041 retina development in camera-type eye
GO:0060562 epithelial tube morphogenesis
GO:0061138 morphogenesis of a branching epithelium
GO:0061298 retina vasculature development in camera-type eye
GO:0061299 retina vasculature morphogenesis in camera-type eye
GO:0061304 retinal blood vessel morphogenesis
GO:0061326 renal tubule development
GO:0061333 renal tubule morphogenesis
GO:0071229 cellular response to acid chemical
GO:0071230 cellular response to amino acid stimulus
GO:0071417 cellular response to organonitrogen compound
GO:0071711 basement membrane organization
GO:0072001 renal system development
Molecular Function GO:0005201 extracellular matrix structural constituent
GO:0019838 growth factor binding
GO:0030023 extracellular matrix constituent conferring elasticity
GO:0048407 platelet-derived growth factor binding
GO:0097493 structural molecule activity conferring elasticity
Cellular Component GO:0005578 proteinaceous extracellular matrix
GO:0005581 collagen trimer
GO:0005587 collagen type IV trimer
GO:0005604 basement membrane
GO:0005788 endoplasmic reticulum lumen
GO:0044420 extracellular matrix component
GO:0098642 network-forming collagen trimer
GO:0098644 complex of collagen trimers
GO:0098645 collagen network
GO:0098651 basement membrane collagen trimer
> KEGG and Reactome Pathway
 
KEGG hsa04151 PI3K-Akt signaling pathway
hsa04510 Focal adhesion
hsa04512 ECM-receptor interaction
hsa04974 Protein digestion and absorption
Reactome R-HSA-2022090: Assembly of collagen fibrils and other multimeric structures
R-HSA-422475: Axon guidance
R-HSA-2173782: Binding and Uptake of Ligands by Scavenger Receptors
R-HSA-1650814: Collagen biosynthesis and modifying enzymes
R-HSA-8948216: Collagen chain trimerization
R-HSA-1474290: Collagen formation
R-HSA-1266738: Developmental Biology
R-HSA-1474244: Extracellular matrix organization
R-HSA-216083: Integrin cell surface interactions
R-HSA-375165: NCAM signaling for neurite out-growth
R-HSA-419037: NCAM1 interactions
R-HSA-3000480: Scavenging by Class A Receptors
R-HSA-162582: Signal Transduction
R-HSA-186797: Signaling by PDGF
R-HSA-5653656: Vesicle-mediated transport
Summary
SymbolCOL4A1
Namecollagen, type IV, alpha 1
Aliases BSVD; RATOR; COL4A1 NC1 domain; arresten; collagen IV, alpha-1 polypeptide; collagen of basement membrane, a ......
Chromosomal Location13q34
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between COL4A1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolCOL4A1
Namecollagen, type IV, alpha 1
Aliases BSVD; RATOR; COL4A1 NC1 domain; arresten; collagen IV, alpha-1 polypeptide; collagen of basement membrane, a ......
Chromosomal Location13q34
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of COL4A1 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolCOL4A1
Namecollagen, type IV, alpha 1
Aliases BSVD; RATOR; COL4A1 NC1 domain; arresten; collagen IV, alpha-1 polypeptide; collagen of basement membrane, a ......
Chromosomal Location13q34
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of COL4A1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-1.0620.0184
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-1.6490.544
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.6320.753
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.2510.574
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.2230.949
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47-0.2850.95
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.6090.328
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.4290.848
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.8580.725
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 481.2580.602
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 282.5860.46
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.280.0342
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of COL4A1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 141705.9-5.91
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 103033.3-33.30.231
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 277314.812.32.50.744
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 01407.1-7.11
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 275914.813.61.21
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)2117195.913.10.355
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)8612.5012.51
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)131123.19.1140.596
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91622.2022.20.12
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59200200.357
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47250250.364
1329033130MelanomaallAnti-PD-1 (nivolumab) 382710.511.1-0.61
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 221318.27.710.50.63
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1614014.3-14.30.209
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 111307.7-7.71
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 51208.3-8.31
Summary
SymbolCOL4A1
Namecollagen, type IV, alpha 1
Aliases BSVD; RATOR; COL4A1 NC1 domain; arresten; collagen IV, alpha-1 polypeptide; collagen of basement membrane, a ......
Chromosomal Location13q34
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of COL4A1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolCOL4A1
Namecollagen, type IV, alpha 1
Aliases BSVD; RATOR; COL4A1 NC1 domain; arresten; collagen IV, alpha-1 polypeptide; collagen of basement membrane, a ......
Chromosomal Location13q34
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of COL4A1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by COL4A1.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolCOL4A1
Namecollagen, type IV, alpha 1
Aliases BSVD; RATOR; COL4A1 NC1 domain; arresten; collagen IV, alpha-1 polypeptide; collagen of basement membrane, a ......
Chromosomal Location13q34
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of COL4A1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolCOL4A1
Namecollagen, type IV, alpha 1
Aliases BSVD; RATOR; COL4A1 NC1 domain; arresten; collagen IV, alpha-1 polypeptide; collagen of basement membrane, a ......
Chromosomal Location13q34
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of COL4A1 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolCOL4A1
Namecollagen, type IV, alpha 1
Aliases BSVD; RATOR; COL4A1 NC1 domain; arresten; collagen IV, alpha-1 polypeptide; collagen of basement membrane, a ......
Chromosomal Location13q34
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between COL4A1 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolCOL4A1
Namecollagen, type IV, alpha 1
Aliases BSVD; RATOR; COL4A1 NC1 domain; arresten; collagen IV, alpha-1 polypeptide; collagen of basement membrane, a ......
Chromosomal Location13q34
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting COL4A1 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.