Summary | |
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Symbol | COL4A3 |
Name | collagen, type IV, alpha 3 (Goodpasture antigen) |
Aliases | tumstatin; collagen IV, alpha-3 polypeptide; Goodpasture antigen; Collagen alpha-3(IV) chain |
Chromosomal Location | 2q36-q37 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Secreted, extracellular space, extracellular matrix, basement membrane. Note=Colocalizes with COL4A4 and COL4A5 in GBM, tubular basement membrane (TBM) and synaptic basal lamina (BL). |
Domain |
PF01413 C-terminal tandem repeated domain in type 4 procollagen PF01391 Collagen triple helix repeat (20 copies) |
Function |
Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen.; FUNCTION: Tumstatin, a cleavage fragment corresponding to the collagen alpha 3(IV) NC1 domain, possesses both anti-angiogenic and anti-tumor cell activity; these two anti-tumor properties may be regulated via RGD-independent ITGB3-mediated mechanisms. |
Biological Process |
GO:0001525 angiogenesis GO:0001655 urogenital system development GO:0001822 kidney development GO:0003013 circulatory system process GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0007605 sensory perception of sound GO:0008015 blood circulation GO:0009743 response to carbohydrate GO:0009746 response to hexose GO:0009749 response to glucose GO:0010466 negative regulation of peptidase activity GO:0010950 positive regulation of endopeptidase activity GO:0010951 negative regulation of endopeptidase activity GO:0010952 positive regulation of peptidase activity GO:0016525 negative regulation of angiogenesis GO:0030198 extracellular matrix organization GO:0030574 collagen catabolic process GO:0032835 glomerulus development GO:0032836 glomerular basement membrane development GO:0032963 collagen metabolic process GO:0034284 response to monosaccharide GO:0043062 extracellular structure organization GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0044236 multicellular organism metabolic process GO:0044243 multicellular organism catabolic process GO:0044259 multicellular organismal macromolecule metabolic process GO:0045765 regulation of angiogenesis GO:0045861 negative regulation of proteolysis GO:0045862 positive regulation of proteolysis GO:0048514 blood vessel morphogenesis GO:0050954 sensory perception of mechanical stimulus GO:0051346 negative regulation of hydrolase activity GO:0052547 regulation of peptidase activity GO:0052548 regulation of endopeptidase activity GO:0072001 renal system development GO:0072006 nephron development GO:0072577 endothelial cell apoptotic process GO:1901342 regulation of vasculature development GO:1901343 negative regulation of vasculature development GO:1904019 epithelial cell apoptotic process GO:2000116 regulation of cysteine-type endopeptidase activity GO:2000181 negative regulation of blood vessel morphogenesis GO:2001056 positive regulation of cysteine-type endopeptidase activity |
Molecular Function |
GO:0004857 enzyme inhibitor activity GO:0004866 endopeptidase inhibitor activity GO:0005178 integrin binding GO:0005201 extracellular matrix structural constituent GO:0008191 metalloendopeptidase inhibitor activity GO:0030414 peptidase inhibitor activity GO:0050839 cell adhesion molecule binding GO:0061134 peptidase regulator activity GO:0061135 endopeptidase regulator activity |
Cellular Component |
GO:0005578 proteinaceous extracellular matrix GO:0005581 collagen trimer GO:0005587 collagen type IV trimer GO:0005604 basement membrane GO:0005788 endoplasmic reticulum lumen GO:0044420 extracellular matrix component GO:0098642 network-forming collagen trimer GO:0098644 complex of collagen trimers GO:0098645 collagen network GO:0098651 basement membrane collagen trimer |
KEGG |
hsa04151 PI3K-Akt signaling pathway hsa04510 Focal adhesion hsa04512 ECM-receptor interaction hsa04974 Protein digestion and absorption |
Reactome |
R-HSA-2022090: Assembly of collagen fibrils and other multimeric structures R-HSA-422475: Axon guidance R-HSA-1650814: Collagen biosynthesis and modifying enzymes R-HSA-8948216: Collagen chain trimerization R-HSA-1474290: Collagen formation R-HSA-1266738: Developmental Biology R-HSA-1474244: Extracellular matrix organization R-HSA-216083: Integrin cell surface interactions R-HSA-375165: NCAM signaling for neurite out-growth R-HSA-419037: NCAM1 interactions R-HSA-162582: Signal Transduction R-HSA-186797: Signaling by PDGF |
Summary | |
---|---|
Symbol | COL4A3 |
Name | collagen, type IV, alpha 3 (Goodpasture antigen) |
Aliases | tumstatin; collagen IV, alpha-3 polypeptide; Goodpasture antigen; Collagen alpha-3(IV) chain |
Chromosomal Location | 2q36-q37 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between COL4A3 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | COL4A3 |
Name | collagen, type IV, alpha 3 (Goodpasture antigen) |
Aliases | tumstatin; collagen IV, alpha-3 polypeptide; Goodpasture antigen; Collagen alpha-3(IV) chain |
Chromosomal Location | 2q36-q37 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of COL4A3 in screening data sets for detecting immune reponses.
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Summary | |
---|---|
Symbol | COL4A3 |
Name | collagen, type IV, alpha 3 (Goodpasture antigen) |
Aliases | tumstatin; collagen IV, alpha-3 polypeptide; Goodpasture antigen; Collagen alpha-3(IV) chain |
Chromosomal Location | 2q36-q37 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of COL4A3 in various data sets.
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Points in the above scatter plot represent the mutation difference of COL4A3 in various data sets.
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Summary | |
---|---|
Symbol | COL4A3 |
Name | collagen, type IV, alpha 3 (Goodpasture antigen) |
Aliases | tumstatin; collagen IV, alpha-3 polypeptide; Goodpasture antigen; Collagen alpha-3(IV) chain |
Chromosomal Location | 2q36-q37 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of COL4A3. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | COL4A3 |
Name | collagen, type IV, alpha 3 (Goodpasture antigen) |
Aliases | tumstatin; collagen IV, alpha-3 polypeptide; Goodpasture antigen; Collagen alpha-3(IV) chain |
Chromosomal Location | 2q36-q37 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of COL4A3. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by COL4A3. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | COL4A3 |
Name | collagen, type IV, alpha 3 (Goodpasture antigen) |
Aliases | tumstatin; collagen IV, alpha-3 polypeptide; Goodpasture antigen; Collagen alpha-3(IV) chain |
Chromosomal Location | 2q36-q37 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of COL4A3. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | COL4A3 |
Name | collagen, type IV, alpha 3 (Goodpasture antigen) |
Aliases | tumstatin; collagen IV, alpha-3 polypeptide; Goodpasture antigen; Collagen alpha-3(IV) chain |
Chromosomal Location | 2q36-q37 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of COL4A3 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | COL4A3 |
Name | collagen, type IV, alpha 3 (Goodpasture antigen) |
Aliases | tumstatin; collagen IV, alpha-3 polypeptide; Goodpasture antigen; Collagen alpha-3(IV) chain |
Chromosomal Location | 2q36-q37 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between COL4A3 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | COL4A3 |
Name | collagen, type IV, alpha 3 (Goodpasture antigen) |
Aliases | tumstatin; collagen IV, alpha-3 polypeptide; Goodpasture antigen; Collagen alpha-3(IV) chain |
Chromosomal Location | 2q36-q37 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting COL4A3 collected from DrugBank database. |
There is no record. |