Browse COL4A4

Summary
SymbolCOL4A4
Namecollagen, type IV, alpha 4
Aliases CA44; collagen of basement membrane, alpha-4 chain; Collagen IV, alpha-4 polypeptide; Collagen alpha-4(IV) c ......
Chromosomal Location2q35-q37
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Secreted, extracellular space, extracellular matrix, basement membrane Note=Colocalizes with COL4A4 and COL4A5 in GBM, tubular basement membrane (TBM) and synaptic basal lamina (BL).
Domain PF01413 C-terminal tandem repeated domain in type 4 procollagen
PF01391 Collagen triple helix repeat (20 copies)
Function

Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen.

> Gene Ontology
 
Biological Process GO:0001655 urogenital system development
GO:0001822 kidney development
GO:0030198 extracellular matrix organization
GO:0030574 collagen catabolic process
GO:0032835 glomerulus development
GO:0032836 glomerular basement membrane development
GO:0032963 collagen metabolic process
GO:0043062 extracellular structure organization
GO:0044236 multicellular organism metabolic process
GO:0044243 multicellular organism catabolic process
GO:0044259 multicellular organismal macromolecule metabolic process
GO:0072001 renal system development
GO:0072006 nephron development
Molecular Function GO:0005201 extracellular matrix structural constituent
Cellular Component GO:0005578 proteinaceous extracellular matrix
GO:0005581 collagen trimer
GO:0005587 collagen type IV trimer
GO:0005604 basement membrane
GO:0005605 basal lamina
GO:0005788 endoplasmic reticulum lumen
GO:0044420 extracellular matrix component
GO:0098642 network-forming collagen trimer
GO:0098644 complex of collagen trimers
GO:0098645 collagen network
GO:0098651 basement membrane collagen trimer
> KEGG and Reactome Pathway
 
KEGG hsa04151 PI3K-Akt signaling pathway
hsa04510 Focal adhesion
hsa04512 ECM-receptor interaction
hsa04974 Protein digestion and absorption
Reactome R-HSA-2022090: Assembly of collagen fibrils and other multimeric structures
R-HSA-422475: Axon guidance
R-HSA-1650814: Collagen biosynthesis and modifying enzymes
R-HSA-8948216: Collagen chain trimerization
R-HSA-1474290: Collagen formation
R-HSA-1266738: Developmental Biology
R-HSA-1474244: Extracellular matrix organization
R-HSA-216083: Integrin cell surface interactions
R-HSA-375165: NCAM signaling for neurite out-growth
R-HSA-419037: NCAM1 interactions
R-HSA-162582: Signal Transduction
R-HSA-186797: Signaling by PDGF
Summary
SymbolCOL4A4
Namecollagen, type IV, alpha 4
Aliases CA44; collagen of basement membrane, alpha-4 chain; Collagen IV, alpha-4 polypeptide; Collagen alpha-4(IV) c ......
Chromosomal Location2q35-q37
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between COL4A4 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolCOL4A4
Namecollagen, type IV, alpha 4
Aliases CA44; collagen of basement membrane, alpha-4 chain; Collagen IV, alpha-4 polypeptide; Collagen alpha-4(IV) c ......
Chromosomal Location2q35-q37
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of COL4A4 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolCOL4A4
Namecollagen, type IV, alpha 4
Aliases CA44; collagen of basement membrane, alpha-4 chain; Collagen IV, alpha-4 polypeptide; Collagen alpha-4(IV) c ......
Chromosomal Location2q35-q37
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of COL4A4 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.140.585
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)650.0420.926
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.2660.519
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.8150.193
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 591.1360.576
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.4140.877
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.5170.395
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.8440.373
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.180.858
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 48-0.2110.775
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.3620.701
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.0090.974
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of COL4A4 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 141714.35.98.40.576
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 414507.142.90.108
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 277329.68.221.40.0187
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 275929.610.219.40.0311
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)211738.135.32.81
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)862533.3-8.31
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)131146.236.49.80.697
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91611.1011.10.36
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47250250.364
1329033130MelanomaallAnti-PD-1 (nivolumab) 382721.111.1100.338
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 221318.27.710.50.63
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16142514.310.70.657
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolCOL4A4
Namecollagen, type IV, alpha 4
Aliases CA44; collagen of basement membrane, alpha-4 chain; Collagen IV, alpha-4 polypeptide; Collagen alpha-4(IV) c ......
Chromosomal Location2q35-q37
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of COL4A4. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolCOL4A4
Namecollagen, type IV, alpha 4
Aliases CA44; collagen of basement membrane, alpha-4 chain; Collagen IV, alpha-4 polypeptide; Collagen alpha-4(IV) c ......
Chromosomal Location2q35-q37
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of COL4A4. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by COL4A4.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolCOL4A4
Namecollagen, type IV, alpha 4
Aliases CA44; collagen of basement membrane, alpha-4 chain; Collagen IV, alpha-4 polypeptide; Collagen alpha-4(IV) c ......
Chromosomal Location2q35-q37
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of COL4A4. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolCOL4A4
Namecollagen, type IV, alpha 4
Aliases CA44; collagen of basement membrane, alpha-4 chain; Collagen IV, alpha-4 polypeptide; Collagen alpha-4(IV) c ......
Chromosomal Location2q35-q37
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of COL4A4 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolCOL4A4
Namecollagen, type IV, alpha 4
Aliases CA44; collagen of basement membrane, alpha-4 chain; Collagen IV, alpha-4 polypeptide; Collagen alpha-4(IV) c ......
Chromosomal Location2q35-q37
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between COL4A4 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolCOL4A4
Namecollagen, type IV, alpha 4
Aliases CA44; collagen of basement membrane, alpha-4 chain; Collagen IV, alpha-4 polypeptide; Collagen alpha-4(IV) c ......
Chromosomal Location2q35-q37
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting COL4A4 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.