Summary | |
---|---|
Symbol | COL5A2 |
Name | collagen, type V, alpha 2 |
Aliases | AB collagen; collagen, fetal membrane, A polypeptide; type V preprocollagen alpha 2 chain; Collagen alpha-2( ...... |
Chromosomal Location | 2q14-q32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Secreted, extracellular space, extracellular matrix |
Domain |
PF01410 Fibrillar collagen C-terminal domain PF01391 Collagen triple helix repeat (20 copies) PF00093 von Willebrand factor type C domain |
Function |
Type V collagen is a member of group I collagen (fibrillar forming collagen). It is a minor connective tissue component of nearly ubiquitous distribution. Type V collagen binds to DNA, heparan sulfate, thrombospondin, heparin, and insulin. Type V collagen is a key determinant in the assembly of tissue-specific matrices (By similarity). |
Biological Process |
GO:0001101 response to acid chemical GO:0001501 skeletal system development GO:0001503 ossification GO:0001654 eye development GO:0001704 formation of primary germ layer GO:0001706 endoderm formation GO:0007369 gastrulation GO:0007423 sensory organ development GO:0007492 endoderm development GO:0010470 regulation of gastrulation GO:0030198 extracellular matrix organization GO:0030199 collagen fibril organization GO:0030574 collagen catabolic process GO:0032963 collagen metabolic process GO:0035987 endodermal cell differentiation GO:0043062 extracellular structure organization GO:0043200 response to amino acid GO:0043588 skin development GO:0044236 multicellular organism metabolic process GO:0044243 multicellular organism catabolic process GO:0044259 multicellular organismal macromolecule metabolic process GO:0045992 negative regulation of embryonic development GO:0045995 regulation of embryonic development GO:0048592 eye morphogenesis GO:0071229 cellular response to acid chemical GO:0071230 cellular response to amino acid stimulus GO:0071417 cellular response to organonitrogen compound GO:0090596 sensory organ morphogenesis GO:1903224 regulation of endodermal cell differentiation GO:1903225 negative regulation of endodermal cell differentiation GO:2000542 negative regulation of gastrulation |
Molecular Function |
GO:0005201 extracellular matrix structural constituent GO:0046332 SMAD binding |
Cellular Component |
GO:0005578 proteinaceous extracellular matrix GO:0005581 collagen trimer GO:0005583 fibrillar collagen trimer GO:0005588 collagen type V trimer GO:0005788 endoplasmic reticulum lumen GO:0044420 extracellular matrix component GO:0098643 banded collagen fibril GO:0098644 complex of collagen trimers |
KEGG |
hsa04974 Protein digestion and absorption |
Reactome |
R-HSA-2022090: Assembly of collagen fibrils and other multimeric structures R-HSA-1650814: Collagen biosynthesis and modifying enzymes R-HSA-8948216: Collagen chain trimerization R-HSA-1474290: Collagen formation R-HSA-1474244: Extracellular matrix organization |
Summary | |
---|---|
Symbol | COL5A2 |
Name | collagen, type V, alpha 2 |
Aliases | AB collagen; collagen, fetal membrane, A polypeptide; type V preprocollagen alpha 2 chain; Collagen alpha-2( ...... |
Chromosomal Location | 2q14-q32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between COL5A2 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | COL5A2 |
Name | collagen, type V, alpha 2 |
Aliases | AB collagen; collagen, fetal membrane, A polypeptide; type V preprocollagen alpha 2 chain; Collagen alpha-2( ...... |
Chromosomal Location | 2q14-q32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
[ TOP ]
|
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Statistical results of COL5A2 in screening data sets for detecting immune reponses.
|
Summary | |
---|---|
Symbol | COL5A2 |
Name | collagen, type V, alpha 2 |
Aliases | AB collagen; collagen, fetal membrane, A polypeptide; type V preprocollagen alpha 2 chain; Collagen alpha-2( ...... |
Chromosomal Location | 2q14-q32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of COL5A2 in various data sets.
|
Points in the above scatter plot represent the mutation difference of COL5A2 in various data sets.
|
Summary | |
---|---|
Symbol | COL5A2 |
Name | collagen, type V, alpha 2 |
Aliases | AB collagen; collagen, fetal membrane, A polypeptide; type V preprocollagen alpha 2 chain; Collagen alpha-2( ...... |
Chromosomal Location | 2q14-q32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of COL5A2. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | COL5A2 |
Name | collagen, type V, alpha 2 |
Aliases | AB collagen; collagen, fetal membrane, A polypeptide; type V preprocollagen alpha 2 chain; Collagen alpha-2( ...... |
Chromosomal Location | 2q14-q32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of COL5A2. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by COL5A2. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | COL5A2 |
Name | collagen, type V, alpha 2 |
Aliases | AB collagen; collagen, fetal membrane, A polypeptide; type V preprocollagen alpha 2 chain; Collagen alpha-2( ...... |
Chromosomal Location | 2q14-q32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of COL5A2. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | COL5A2 |
Name | collagen, type V, alpha 2 |
Aliases | AB collagen; collagen, fetal membrane, A polypeptide; type V preprocollagen alpha 2 chain; Collagen alpha-2( ...... |
Chromosomal Location | 2q14-q32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of COL5A2 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | COL5A2 |
Name | collagen, type V, alpha 2 |
Aliases | AB collagen; collagen, fetal membrane, A polypeptide; type V preprocollagen alpha 2 chain; Collagen alpha-2( ...... |
Chromosomal Location | 2q14-q32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between COL5A2 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | COL5A2 |
Name | collagen, type V, alpha 2 |
Aliases | AB collagen; collagen, fetal membrane, A polypeptide; type V preprocollagen alpha 2 chain; Collagen alpha-2( ...... |
Chromosomal Location | 2q14-q32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting COL5A2 collected from DrugBank database. |
There is no record. |