Summary | |
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Symbol | COL6A6 |
Name | collagen, type VI, alpha 6 |
Aliases | Collagen alpha-6(VI) chain |
Chromosomal Location | 3q22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Secreted, extracellular space, extracellular matrix Note=Deposed in the extracellular matrix of skeletal muscle. |
Domain |
PF01391 Collagen triple helix repeat (20 copies) PF00092 von Willebrand factor type A domain |
Function |
Collagen VI acts as a cell-binding protein. |
Biological Process |
GO:0030574 collagen catabolic process GO:0032963 collagen metabolic process GO:0044236 multicellular organism metabolic process GO:0044243 multicellular organism catabolic process GO:0044259 multicellular organismal macromolecule metabolic process |
Molecular Function | - |
Cellular Component |
GO:0005578 proteinaceous extracellular matrix GO:0005581 collagen trimer |
KEGG |
hsa04151 PI3K-Akt signaling pathway hsa04510 Focal adhesion hsa04512 ECM-receptor interaction hsa04974 Protein digestion and absorption |
Reactome |
R-HSA-2022090: Assembly of collagen fibrils and other multimeric structures R-HSA-422475: Axon guidance R-HSA-1650814: Collagen biosynthesis and modifying enzymes R-HSA-8948216: Collagen chain trimerization R-HSA-1474290: Collagen formation R-HSA-1266738: Developmental Biology R-HSA-1474244: Extracellular matrix organization R-HSA-375165: NCAM signaling for neurite out-growth R-HSA-419037: NCAM1 interactions R-HSA-162582: Signal Transduction R-HSA-186797: Signaling by PDGF |
Summary | |
---|---|
Symbol | COL6A6 |
Name | collagen, type VI, alpha 6 |
Aliases | Collagen alpha-6(VI) chain |
Chromosomal Location | 3q22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between COL6A6 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | COL6A6 |
Name | collagen, type VI, alpha 6 |
Aliases | Collagen alpha-6(VI) chain |
Chromosomal Location | 3q22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of COL6A6 in screening data sets for detecting immune reponses.
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Summary | |
---|---|
Symbol | COL6A6 |
Name | collagen, type VI, alpha 6 |
Aliases | Collagen alpha-6(VI) chain |
Chromosomal Location | 3q22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of COL6A6 in various data sets.
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Points in the above scatter plot represent the mutation difference of COL6A6 in various data sets.
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Summary | |
---|---|
Symbol | COL6A6 |
Name | collagen, type VI, alpha 6 |
Aliases | Collagen alpha-6(VI) chain |
Chromosomal Location | 3q22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of COL6A6. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | COL6A6 |
Name | collagen, type VI, alpha 6 |
Aliases | Collagen alpha-6(VI) chain |
Chromosomal Location | 3q22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of COL6A6. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by COL6A6. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | COL6A6 |
Name | collagen, type VI, alpha 6 |
Aliases | Collagen alpha-6(VI) chain |
Chromosomal Location | 3q22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of COL6A6. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | COL6A6 |
Name | collagen, type VI, alpha 6 |
Aliases | Collagen alpha-6(VI) chain |
Chromosomal Location | 3q22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of COL6A6 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | COL6A6 |
Name | collagen, type VI, alpha 6 |
Aliases | Collagen alpha-6(VI) chain |
Chromosomal Location | 3q22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between COL6A6 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |