Browse COL8A1

Summary
SymbolCOL8A1
Namecollagen, type VIII, alpha 1
Aliases MGC9568; C3orf7; chromosome 3 open reading frame 7; cell proliferation-inducing protein 41; collagen VIII, a ......
Chromosomal Location3q11.1-q13.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Secreted, extracellular space, extracellular matrix, basement membrane.
Domain PF00386 C1q domain
PF01391 Collagen triple helix repeat (20 copies)
Function

Macromolecular component of the subendothelium. Major component of the Descemet's membrane (basement membrane) of corneal endothelial cells. Also component of the endothelia of blood vessels. Necessary for migration and proliferation of vascular smooth muscle cells and thus, has a potential role in the maintenance of vessel wall integrity and structure, in particular in atherogenesis. ; FUNCTION: Vastatin, the C-terminal fragment comprising the NC1 domain, inhibits aortic endothelial cell proliferation and causes cell apoptosis.

> Gene Ontology
 
Biological Process GO:0001525 angiogenesis
GO:0001654 eye development
GO:0001704 formation of primary germ layer
GO:0001706 endoderm formation
GO:0007369 gastrulation
GO:0007423 sensory organ development
GO:0007492 endoderm development
GO:0010810 regulation of cell-substrate adhesion
GO:0010811 positive regulation of cell-substrate adhesion
GO:0030198 extracellular matrix organization
GO:0030574 collagen catabolic process
GO:0031589 cell-substrate adhesion
GO:0032963 collagen metabolic process
GO:0035987 endodermal cell differentiation
GO:0043010 camera-type eye development
GO:0043062 extracellular structure organization
GO:0044236 multicellular organism metabolic process
GO:0044243 multicellular organism catabolic process
GO:0044259 multicellular organismal macromolecule metabolic process
GO:0045785 positive regulation of cell adhesion
GO:0048514 blood vessel morphogenesis
GO:0048592 eye morphogenesis
GO:0048593 camera-type eye morphogenesis
GO:0050673 epithelial cell proliferation
GO:0090596 sensory organ morphogenesis
Molecular Function -
Cellular Component GO:0005578 proteinaceous extracellular matrix
GO:0005581 collagen trimer
GO:0005591 collagen type VIII trimer
GO:0005598 short-chain collagen trimer
GO:0005604 basement membrane
GO:0005788 endoplasmic reticulum lumen
GO:0030935 sheet-forming collagen trimer
GO:0044420 extracellular matrix component
GO:0098642 network-forming collagen trimer
GO:0098644 complex of collagen trimers
GO:0098645 collagen network
GO:0098646 collagen sheet
GO:0098651 basement membrane collagen trimer
> KEGG and Reactome Pathway
 
KEGG -
Reactome R-HSA-2022090: Assembly of collagen fibrils and other multimeric structures
R-HSA-1650814: Collagen biosynthesis and modifying enzymes
R-HSA-8948216: Collagen chain trimerization
R-HSA-1474290: Collagen formation
R-HSA-1474244: Extracellular matrix organization
Summary
SymbolCOL8A1
Namecollagen, type VIII, alpha 1
Aliases MGC9568; C3orf7; chromosome 3 open reading frame 7; cell proliferation-inducing protein 41; collagen VIII, a ......
Chromosomal Location3q11.1-q13.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between COL8A1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.

Summary
SymbolCOL8A1
Namecollagen, type VIII, alpha 1
Aliases MGC9568; C3orf7; chromosome 3 open reading frame 7; cell proliferation-inducing protein 41; collagen VIII, a ......
Chromosomal Location3q11.1-q13.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of COL8A1 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolCOL8A1
Namecollagen, type VIII, alpha 1
Aliases MGC9568; C3orf7; chromosome 3 open reading frame 7; cell proliferation-inducing protein 41; collagen VIII, a ......
Chromosomal Location3q11.1-q13.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of COL8A1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-1.8290.00854
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-2.2110.118
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-1.5470.169
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.5760.174
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.7210.739
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47-0.3910.888
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.3260.615
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.1140.923
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.5840.645
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 481.8740.371
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 283.6220.192
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.390.0779
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of COL8A1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27737.45.51.90.66
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 01407.1-7.11
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27597.45.12.30.647
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21174.804.81
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13117.707.71
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38272.63.7-1.11
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22134.57.7-3.21
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolCOL8A1
Namecollagen, type VIII, alpha 1
Aliases MGC9568; C3orf7; chromosome 3 open reading frame 7; cell proliferation-inducing protein 41; collagen VIII, a ......
Chromosomal Location3q11.1-q13.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of COL8A1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolCOL8A1
Namecollagen, type VIII, alpha 1
Aliases MGC9568; C3orf7; chromosome 3 open reading frame 7; cell proliferation-inducing protein 41; collagen VIII, a ......
Chromosomal Location3q11.1-q13.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of COL8A1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by COL8A1.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolCOL8A1
Namecollagen, type VIII, alpha 1
Aliases MGC9568; C3orf7; chromosome 3 open reading frame 7; cell proliferation-inducing protein 41; collagen VIII, a ......
Chromosomal Location3q11.1-q13.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of COL8A1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolCOL8A1
Namecollagen, type VIII, alpha 1
Aliases MGC9568; C3orf7; chromosome 3 open reading frame 7; cell proliferation-inducing protein 41; collagen VIII, a ......
Chromosomal Location3q11.1-q13.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of COL8A1 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolCOL8A1
Namecollagen, type VIII, alpha 1
Aliases MGC9568; C3orf7; chromosome 3 open reading frame 7; cell proliferation-inducing protein 41; collagen VIII, a ......
Chromosomal Location3q11.1-q13.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between COL8A1 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolCOL8A1
Namecollagen, type VIII, alpha 1
Aliases MGC9568; C3orf7; chromosome 3 open reading frame 7; cell proliferation-inducing protein 41; collagen VIII, a ......
Chromosomal Location3q11.1-q13.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting COL8A1 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.