Browse COLEC12

Summary
SymbolCOLEC12
Namecollectin sub-family member 12
Aliases SRCL; CL-P1; SCARA4; NSR2; collectin placenta protein 1; hCL-P1; nurse cell scavenger receptor 2; scavenger ......
Chromosomal Location18p11.32
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Membrane Single-pass type II membrane protein Note=Forms clusters on the cell surface.
Domain PF01391 Collagen triple helix repeat (20 copies)
PF00059 Lectin C-type domain
Function

Scavenger receptor that displays several functions associated with host defense. Promotes binding and phagocytosis of Gram-positive, Gram-negative bacteria and yeast. Mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. Binds to several carbohydrates including Gal-type ligands, D-galactose, L- and D-fucose, GalNAc, T and Tn antigens in a calcium-dependent manner and internalizes specifically GalNAc in nurse-like cells. Binds also to sialyl Lewis X or a trisaccharide and asialo-orosomucoid (ASOR). May also play a role in the clearance of amyloid-beta in Alzheimer disease.

> Gene Ontology
 
Biological Process GO:0002218 activation of innate immune response
GO:0002221 pattern recognition receptor signaling pathway
GO:0002224 toll-like receptor signaling pathway
GO:0002757 immune response-activating signal transduction
GO:0002758 innate immune response-activating signal transduction
GO:0002764 immune response-regulating signaling pathway
GO:0006898 receptor-mediated endocytosis
GO:0006909 phagocytosis
GO:0006910 phagocytosis, recognition
GO:0008037 cell recognition
GO:0009743 response to carbohydrate
GO:0009756 carbohydrate mediated signaling
GO:0031349 positive regulation of defense response
GO:0034138 toll-like receptor 3 signaling pathway
GO:0043330 response to exogenous dsRNA
GO:0043331 response to dsRNA
GO:0045088 regulation of innate immune response
GO:0045089 positive regulation of innate immune response
GO:0051259 protein oligomerization
GO:0051260 protein homooligomerization
GO:0060352 cell adhesion molecule production
GO:0060353 regulation of cell adhesion molecule production
GO:0060355 positive regulation of cell adhesion molecule production
GO:0071322 cellular response to carbohydrate stimulus
GO:0071359 cellular response to dsRNA
GO:0071360 cellular response to exogenous dsRNA
GO:0071407 cellular response to organic cyclic compound
Molecular Function GO:0005044 scavenger receptor activity
GO:0005534 galactose binding
GO:0008329 signaling pattern recognition receptor activity
GO:0030169 low-density lipoprotein particle binding
GO:0030246 carbohydrate binding
GO:0038024 cargo receptor activity
GO:0038187 pattern recognition receptor activity
GO:0048029 monosaccharide binding
GO:0071813 lipoprotein particle binding
GO:0071814 protein-lipid complex binding
Cellular Component GO:0005581 collagen trimer
GO:0030139 endocytic vesicle
GO:0030659 cytoplasmic vesicle membrane
GO:0030666 endocytic vesicle membrane
> KEGG and Reactome Pathway
 
KEGG hsa04145 Phagosome
Reactome R-HSA-2173782: Binding and Uptake of Ligands by Scavenger Receptors
R-HSA-3000480: Scavenging by Class A Receptors
R-HSA-5653656: Vesicle-mediated transport
Summary
SymbolCOLEC12
Namecollectin sub-family member 12
Aliases SRCL; CL-P1; SCARA4; NSR2; collectin placenta protein 1; hCL-P1; nurse cell scavenger receptor 2; scavenger ......
Chromosomal Location18p11.32
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between COLEC12 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.

Summary
SymbolCOLEC12
Namecollectin sub-family member 12
Aliases SRCL; CL-P1; SCARA4; NSR2; collectin placenta protein 1; hCL-P1; nurse cell scavenger receptor 2; scavenger ......
Chromosomal Location18p11.32
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of COLEC12 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolCOLEC12
Namecollectin sub-family member 12
Aliases SRCL; CL-P1; SCARA4; NSR2; collectin placenta protein 1; hCL-P1; nurse cell scavenger receptor 2; scavenger ......
Chromosomal Location18p11.32
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of COLEC12 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-1.0970.0301
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-1.2920.38
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.9380.309
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.3180.577
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.0520.977
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47-0.6470.787
729033130MelanomaallAnti-PD-1 (nivolumab) 2623-0.4530.334
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-0.190.892
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-0.7460.626
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.0970.929
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 281.1410.405
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.5930.00826
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of COLEC12 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 141705.9-5.91
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 103033.3-33.30.231
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 277301.4-1.41
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 275901.7-1.71
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)211714.317.6-3.31
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)86250250.473
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13117.727.3-19.60.3
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38275.33.71.61
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22134.504.51
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16146.27.1-0.91
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolCOLEC12
Namecollectin sub-family member 12
Aliases SRCL; CL-P1; SCARA4; NSR2; collectin placenta protein 1; hCL-P1; nurse cell scavenger receptor 2; scavenger ......
Chromosomal Location18p11.32
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of COLEC12. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolCOLEC12
Namecollectin sub-family member 12
Aliases SRCL; CL-P1; SCARA4; NSR2; collectin placenta protein 1; hCL-P1; nurse cell scavenger receptor 2; scavenger ......
Chromosomal Location18p11.32
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of COLEC12. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by COLEC12.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolCOLEC12
Namecollectin sub-family member 12
Aliases SRCL; CL-P1; SCARA4; NSR2; collectin placenta protein 1; hCL-P1; nurse cell scavenger receptor 2; scavenger ......
Chromosomal Location18p11.32
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of COLEC12. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolCOLEC12
Namecollectin sub-family member 12
Aliases SRCL; CL-P1; SCARA4; NSR2; collectin placenta protein 1; hCL-P1; nurse cell scavenger receptor 2; scavenger ......
Chromosomal Location18p11.32
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of COLEC12 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolCOLEC12
Namecollectin sub-family member 12
Aliases SRCL; CL-P1; SCARA4; NSR2; collectin placenta protein 1; hCL-P1; nurse cell scavenger receptor 2; scavenger ......
Chromosomal Location18p11.32
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between COLEC12 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolCOLEC12
Namecollectin sub-family member 12
Aliases SRCL; CL-P1; SCARA4; NSR2; collectin placenta protein 1; hCL-P1; nurse cell scavenger receptor 2; scavenger ......
Chromosomal Location18p11.32
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting COLEC12 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.