Summary | |
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Symbol | COPS6 |
Name | COP9 signalosome subunit 6 |
Aliases | MOV34-34KD; CSN6; COP9 subunit 6 (MOV34 homolog, 34 kD); COP9 constitutive photomorphogenic homolog subunit ...... |
Chromosomal Location | 7q22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Nucleus. Cytoplasm. Note=The interaction with HIV-1 Vpr protein possibly leads its translocation to a perinuclear region. |
Domain |
PF01398 JAB1/Mov34/MPN/PAD-1 ubiquitin protease PF13012 Maintenance of mitochondrial structure and function |
Function |
Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Has some glucocorticoid receptor-responsive activity. Stabilizes COP1 through reducing COP1 auto-ubiquitination and decelerating COP1 turnover rate, hence regulates the ubiquitination of COP1 targets. |
Biological Process |
GO:0000338 protein deneddylation GO:0000715 nucleotide-excision repair, DNA damage recognition GO:0006283 transcription-coupled nucleotide-excision repair GO:0006289 nucleotide-excision repair GO:0010388 cullin deneddylation GO:0070646 protein modification by small protein removal |
Molecular Function | - |
Cellular Component |
GO:0008180 COP9 signalosome |
KEGG | - |
Reactome |
R-HSA-8856825: Cargo recognition for clathrin-mediated endocytosis R-HSA-8856828: Clathrin-mediated endocytosis R-HSA-5696394: DNA Damage Recognition in GG-NER R-HSA-73894: DNA Repair R-HSA-6781823: Formation of TC-NER Pre-Incision Complex R-HSA-5696399: Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-199991: Membrane Trafficking R-HSA-5696398: Nucleotide Excision Repair R-HSA-6781827: Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-5653656: Vesicle-mediated transport |
Summary | |
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Symbol | COPS6 |
Name | COP9 signalosome subunit 6 |
Aliases | MOV34-34KD; CSN6; COP9 subunit 6 (MOV34 homolog, 34 kD); COP9 constitutive photomorphogenic homolog subunit ...... |
Chromosomal Location | 7q22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between COPS6 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | COPS6 |
Name | COP9 signalosome subunit 6 |
Aliases | MOV34-34KD; CSN6; COP9 subunit 6 (MOV34 homolog, 34 kD); COP9 constitutive photomorphogenic homolog subunit ...... |
Chromosomal Location | 7q22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of COPS6 in screening data sets for detecting immune reponses.
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Summary | |
---|---|
Symbol | COPS6 |
Name | COP9 signalosome subunit 6 |
Aliases | MOV34-34KD; CSN6; COP9 subunit 6 (MOV34 homolog, 34 kD); COP9 constitutive photomorphogenic homolog subunit ...... |
Chromosomal Location | 7q22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of COPS6 in various data sets.
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Points in the above scatter plot represent the mutation difference of COPS6 in various data sets.
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Summary | |
---|---|
Symbol | COPS6 |
Name | COP9 signalosome subunit 6 |
Aliases | MOV34-34KD; CSN6; COP9 subunit 6 (MOV34 homolog, 34 kD); COP9 constitutive photomorphogenic homolog subunit ...... |
Chromosomal Location | 7q22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of COPS6. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | COPS6 |
Name | COP9 signalosome subunit 6 |
Aliases | MOV34-34KD; CSN6; COP9 subunit 6 (MOV34 homolog, 34 kD); COP9 constitutive photomorphogenic homolog subunit ...... |
Chromosomal Location | 7q22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of COPS6. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by COPS6. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | COPS6 |
Name | COP9 signalosome subunit 6 |
Aliases | MOV34-34KD; CSN6; COP9 subunit 6 (MOV34 homolog, 34 kD); COP9 constitutive photomorphogenic homolog subunit ...... |
Chromosomal Location | 7q22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of COPS6. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | COPS6 |
Name | COP9 signalosome subunit 6 |
Aliases | MOV34-34KD; CSN6; COP9 subunit 6 (MOV34 homolog, 34 kD); COP9 constitutive photomorphogenic homolog subunit ...... |
Chromosomal Location | 7q22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of COPS6 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | COPS6 |
Name | COP9 signalosome subunit 6 |
Aliases | MOV34-34KD; CSN6; COP9 subunit 6 (MOV34 homolog, 34 kD); COP9 constitutive photomorphogenic homolog subunit ...... |
Chromosomal Location | 7q22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between COPS6 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | COPS6 |
Name | COP9 signalosome subunit 6 |
Aliases | MOV34-34KD; CSN6; COP9 subunit 6 (MOV34 homolog, 34 kD); COP9 constitutive photomorphogenic homolog subunit ...... |
Chromosomal Location | 7q22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting COPS6 collected from DrugBank database. |
There is no record. |