Summary | |
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Symbol | COX7B2 |
Name | cytochrome c oxidase subunit VIIb2 |
Aliases | cytochrome c oxidase polypeptide VIIb2; Cytochrome c oxidase subunit 7B2, mitochondrial |
Chromosomal Location | 4p12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Mitochondrion inner membrane |
Domain |
PF05392 Cytochrome C oxidase chain VIIB |
Function |
This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport. |
Biological Process |
GO:0006818 hydrogen transport GO:0015672 monovalent inorganic cation transport GO:0015992 proton transport GO:1902600 hydrogen ion transmembrane transport |
Molecular Function |
GO:0004129 cytochrome-c oxidase activity GO:0009055 electron carrier activity GO:0015002 heme-copper terminal oxidase activity GO:0015077 monovalent inorganic cation transmembrane transporter activity GO:0015078 hydrogen ion transmembrane transporter activity GO:0016675 oxidoreductase activity, acting on a heme group of donors GO:0016676 oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor |
Cellular Component |
GO:0005743 mitochondrial inner membrane GO:0005746 mitochondrial respiratory chain GO:0044455 mitochondrial membrane part GO:0045277 respiratory chain complex IV GO:0070069 cytochrome complex GO:0070469 respiratory chain GO:0098803 respiratory chain complex |
KEGG |
hsa04260 Cardiac muscle contraction hsa00190 Oxidative phosphorylation hsa01100 Metabolic pathways |
Reactome | - |
Summary | |
---|---|
Symbol | COX7B2 |
Name | cytochrome c oxidase subunit VIIb2 |
Aliases | cytochrome c oxidase polypeptide VIIb2; Cytochrome c oxidase subunit 7B2, mitochondrial |
Chromosomal Location | 4p12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between COX7B2 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | COX7B2 |
Name | cytochrome c oxidase subunit VIIb2 |
Aliases | cytochrome c oxidase polypeptide VIIb2; Cytochrome c oxidase subunit 7B2, mitochondrial |
Chromosomal Location | 4p12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of COX7B2 in screening data sets for detecting immune reponses.
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Summary | |
---|---|
Symbol | COX7B2 |
Name | cytochrome c oxidase subunit VIIb2 |
Aliases | cytochrome c oxidase polypeptide VIIb2; Cytochrome c oxidase subunit 7B2, mitochondrial |
Chromosomal Location | 4p12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of COX7B2 in various data sets.
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Points in the above scatter plot represent the mutation difference of COX7B2 in various data sets.
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Summary | |
---|---|
Symbol | COX7B2 |
Name | cytochrome c oxidase subunit VIIb2 |
Aliases | cytochrome c oxidase polypeptide VIIb2; Cytochrome c oxidase subunit 7B2, mitochondrial |
Chromosomal Location | 4p12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of COX7B2. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | COX7B2 |
Name | cytochrome c oxidase subunit VIIb2 |
Aliases | cytochrome c oxidase polypeptide VIIb2; Cytochrome c oxidase subunit 7B2, mitochondrial |
Chromosomal Location | 4p12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of COX7B2. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by COX7B2. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | COX7B2 |
Name | cytochrome c oxidase subunit VIIb2 |
Aliases | cytochrome c oxidase polypeptide VIIb2; Cytochrome c oxidase subunit 7B2, mitochondrial |
Chromosomal Location | 4p12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of COX7B2. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | COX7B2 |
Name | cytochrome c oxidase subunit VIIb2 |
Aliases | cytochrome c oxidase polypeptide VIIb2; Cytochrome c oxidase subunit 7B2, mitochondrial |
Chromosomal Location | 4p12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of COX7B2 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | COX7B2 |
Name | cytochrome c oxidase subunit VIIb2 |
Aliases | cytochrome c oxidase polypeptide VIIb2; Cytochrome c oxidase subunit 7B2, mitochondrial |
Chromosomal Location | 4p12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between COX7B2 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | COX7B2 |
Name | cytochrome c oxidase subunit VIIb2 |
Aliases | cytochrome c oxidase polypeptide VIIb2; Cytochrome c oxidase subunit 7B2, mitochondrial |
Chromosomal Location | 4p12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting COX7B2 collected from DrugBank database. |
There is no record. |