Browse COX7B2

Summary
SymbolCOX7B2
Namecytochrome c oxidase subunit VIIb2
Aliases cytochrome c oxidase polypeptide VIIb2; Cytochrome c oxidase subunit 7B2, mitochondrial
Chromosomal Location4p12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Mitochondrion inner membrane
Domain PF05392 Cytochrome C oxidase chain VIIB
Function

This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.

> Gene Ontology
 
Biological Process GO:0006818 hydrogen transport
GO:0015672 monovalent inorganic cation transport
GO:0015992 proton transport
GO:1902600 hydrogen ion transmembrane transport
Molecular Function GO:0004129 cytochrome-c oxidase activity
GO:0009055 electron carrier activity
GO:0015002 heme-copper terminal oxidase activity
GO:0015077 monovalent inorganic cation transmembrane transporter activity
GO:0015078 hydrogen ion transmembrane transporter activity
GO:0016675 oxidoreductase activity, acting on a heme group of donors
GO:0016676 oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
Cellular Component GO:0005743 mitochondrial inner membrane
GO:0005746 mitochondrial respiratory chain
GO:0044455 mitochondrial membrane part
GO:0045277 respiratory chain complex IV
GO:0070069 cytochrome complex
GO:0070469 respiratory chain
GO:0098803 respiratory chain complex
> KEGG and Reactome Pathway
 
KEGG hsa04260 Cardiac muscle contraction
hsa00190 Oxidative phosphorylation
hsa01100 Metabolic pathways
Reactome -
Summary
SymbolCOX7B2
Namecytochrome c oxidase subunit VIIb2
Aliases cytochrome c oxidase polypeptide VIIb2; Cytochrome c oxidase subunit 7B2, mitochondrial
Chromosomal Location4p12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between COX7B2 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.

Summary
SymbolCOX7B2
Namecytochrome c oxidase subunit VIIb2
Aliases cytochrome c oxidase polypeptide VIIb2; Cytochrome c oxidase subunit 7B2, mitochondrial
Chromosomal Location4p12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of COX7B2 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolCOX7B2
Namecytochrome c oxidase subunit VIIb2
Aliases cytochrome c oxidase polypeptide VIIb2; Cytochrome c oxidase subunit 7B2, mitochondrial
Chromosomal Location4p12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of COX7B2 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)141201
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)6501
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)8701
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.3560.691
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-1.3130.438
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.8760.591
729033130MelanomaallAnti-PD-1 (nivolumab) 262301
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 151101
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 111201
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 4801
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 2801
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.5980.0417
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of COX7B2 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14177.107.10.452
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 103100101
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27730001
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27590001
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21170001
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38272.602.61
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22130001
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16146.206.21
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolCOX7B2
Namecytochrome c oxidase subunit VIIb2
Aliases cytochrome c oxidase polypeptide VIIb2; Cytochrome c oxidase subunit 7B2, mitochondrial
Chromosomal Location4p12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of COX7B2. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolCOX7B2
Namecytochrome c oxidase subunit VIIb2
Aliases cytochrome c oxidase polypeptide VIIb2; Cytochrome c oxidase subunit 7B2, mitochondrial
Chromosomal Location4p12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of COX7B2. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by COX7B2.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolCOX7B2
Namecytochrome c oxidase subunit VIIb2
Aliases cytochrome c oxidase polypeptide VIIb2; Cytochrome c oxidase subunit 7B2, mitochondrial
Chromosomal Location4p12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of COX7B2. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolCOX7B2
Namecytochrome c oxidase subunit VIIb2
Aliases cytochrome c oxidase polypeptide VIIb2; Cytochrome c oxidase subunit 7B2, mitochondrial
Chromosomal Location4p12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of COX7B2 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolCOX7B2
Namecytochrome c oxidase subunit VIIb2
Aliases cytochrome c oxidase polypeptide VIIb2; Cytochrome c oxidase subunit 7B2, mitochondrial
Chromosomal Location4p12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between COX7B2 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolCOX7B2
Namecytochrome c oxidase subunit VIIb2
Aliases cytochrome c oxidase polypeptide VIIb2; Cytochrome c oxidase subunit 7B2, mitochondrial
Chromosomal Location4p12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting COX7B2 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.