Summary | |
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Symbol | CPS1 |
Name | carbamoyl-phosphate synthase 1, mitochondrial |
Aliases | carbamoyl-phosphate synthetase 1, mitochondrial; CPSASE1; PHN; carbamoylphosphate synthetase I; CPSase I; Ca ...... |
Chromosomal Location | 2p |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Mitochondrion Nucleus, nucleolus |
Domain |
PF02786 Carbamoyl-phosphate synthase L chain PF02787 Carbamoyl-phosphate synthetase large chain PF00988 Carbamoyl-phosphate synthase small chain PF00117 Glutamine amidotransferase class-I PF02142 MGS-like domain |
Function |
Involved in the urea cycle of ureotelic animals where the enzyme plays an important role in removing excess ammonia from the cell. |
Biological Process |
GO:0000050 urea cycle GO:0000052 citrulline metabolic process GO:0000096 sulfur amino acid metabolic process GO:0000272 polysaccharide catabolic process GO:0001101 response to acid chemical GO:0001889 liver development GO:0002237 response to molecule of bacterial origin GO:0003013 circulatory system process GO:0003018 vascular process in circulatory system GO:0005976 polysaccharide metabolic process GO:0005977 glycogen metabolic process GO:0005980 glycogen catabolic process GO:0006073 cellular glucan metabolic process GO:0006091 generation of precursor metabolites and energy GO:0006112 energy reserve metabolic process GO:0006206 pyrimidine nucleobase metabolic process GO:0006207 'de novo' pyrimidine nucleobase biosynthetic process GO:0006520 cellular amino acid metabolic process GO:0006525 arginine metabolic process GO:0006526 arginine biosynthetic process GO:0006541 glutamine metabolic process GO:0006638 neutral lipid metabolic process GO:0006639 acylglycerol metabolic process GO:0006641 triglyceride metabolic process GO:0006790 sulfur compound metabolic process GO:0007494 midgut development GO:0008015 blood circulation GO:0008652 cellular amino acid biosynthetic process GO:0009064 glutamine family amino acid metabolic process GO:0009084 glutamine family amino acid biosynthetic process GO:0009112 nucleobase metabolic process GO:0009251 glucan catabolic process GO:0009636 response to toxic substance GO:0009991 response to extracellular stimulus GO:0010035 response to inorganic substance GO:0010038 response to metal ion GO:0010043 response to zinc ion GO:0014074 response to purine-containing compound GO:0014075 response to amine GO:0015980 energy derivation by oxidation of organic compounds GO:0016042 lipid catabolic process GO:0016052 carbohydrate catabolic process GO:0016053 organic acid biosynthetic process GO:0019240 citrulline biosynthetic process GO:0019433 triglyceride catabolic process GO:0019627 urea metabolic process GO:0019856 pyrimidine nucleobase biosynthetic process GO:0031667 response to nutrient levels GO:0031960 response to corticosteroid GO:0032094 response to food GO:0032496 response to lipopolysaccharide GO:0033762 response to glucagon GO:0034201 response to oleic acid GO:0035150 regulation of tube size GO:0042311 vasodilation GO:0042312 regulation of vasodilation GO:0042493 response to drug GO:0042594 response to starvation GO:0043200 response to amino acid GO:0043434 response to peptide hormone GO:0044042 glucan metabolic process GO:0044057 regulation of system process GO:0044242 cellular lipid catabolic process GO:0044247 cellular polysaccharide catabolic process GO:0044262 cellular carbohydrate metabolic process GO:0044264 cellular polysaccharide metabolic process GO:0044275 cellular carbohydrate catabolic process GO:0044283 small molecule biosynthetic process GO:0044344 cellular response to fibroblast growth factor stimulus GO:0044723 single-organism carbohydrate metabolic process GO:0044724 single-organism carbohydrate catabolic process GO:0045909 positive regulation of vasodilation GO:0046112 nucleobase biosynthetic process GO:0046209 nitric oxide metabolic process GO:0046394 carboxylic acid biosynthetic process GO:0046461 neutral lipid catabolic process GO:0046464 acylglycerol catabolic process GO:0046486 glycerolipid metabolic process GO:0046503 glycerolipid catabolic process GO:0046683 response to organophosphorus GO:0048545 response to steroid hormone GO:0048565 digestive tract development GO:0048732 gland development GO:0050667 homocysteine metabolic process GO:0050880 regulation of blood vessel size GO:0051384 response to glucocorticoid GO:0051591 response to cAMP GO:0055081 anion homeostasis GO:0055123 digestive system development GO:0060416 response to growth hormone GO:0061008 hepaticobiliary system development GO:0070365 hepatocyte differentiation GO:0070408 carbamoyl phosphate metabolic process GO:0070409 carbamoyl phosphate biosynthetic process GO:0071320 cellular response to cAMP GO:0071375 cellular response to peptide hormone stimulus GO:0071377 cellular response to glucagon stimulus GO:0071396 cellular response to lipid GO:0071400 cellular response to oleic acid GO:0071407 cellular response to organic cyclic compound GO:0071417 cellular response to organonitrogen compound GO:0071548 response to dexamethasone GO:0071774 response to fibroblast growth factor GO:0071941 nitrogen cycle metabolic process GO:0072527 pyrimidine-containing compound metabolic process GO:0072528 pyrimidine-containing compound biosynthetic process GO:0072593 reactive oxygen species metabolic process GO:0090066 regulation of anatomical structure size GO:1901605 alpha-amino acid metabolic process GO:1901607 alpha-amino acid biosynthetic process GO:1901652 response to peptide GO:1901653 cellular response to peptide GO:1901654 response to ketone GO:1903522 regulation of blood circulation GO:1903524 positive regulation of blood circulation GO:1990267 response to transition metal nanoparticle GO:2001057 reactive nitrogen species metabolic process |
Molecular Function |
GO:0004070 aspartate carbamoyltransferase activity GO:0004087 carbamoyl-phosphate synthase (ammonia) activity GO:0004088 carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity GO:0004151 dihydroorotase activity GO:0004175 endopeptidase activity GO:0005543 phospholipid binding GO:0016595 glutamate binding GO:0016741 transferase activity, transferring one-carbon groups GO:0016743 carboxyl- or carbamoyltransferase activity GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds GO:0016812 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides GO:0016874 ligase activity GO:0016879 ligase activity, forming carbon-nitrogen bonds GO:0016884 carbon-nitrogen ligase activity, with glutamine as amido-N-donor GO:0031406 carboxylic acid binding GO:0043168 anion binding GO:0072341 modified amino acid binding |
Cellular Component |
GO:0005743 mitochondrial inner membrane GO:0005759 mitochondrial matrix GO:0009295 nucleoid GO:0042645 mitochondrial nucleoid |
KEGG |
hsa00250 Alanine, aspartate and glutamate metabolism hsa00910 Nitrogen metabolism hsa01100 Metabolic pathways hsa01200 Carbon metabolism hsa01230 Biosynthesis of amino acids |
Reactome |
R-HSA-1430728: Metabolism R-HSA-71291: Metabolism of amino acids and derivatives R-HSA-351202: Metabolism of polyamines R-HSA-70635: Urea cycle |
Summary | |
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Symbol | CPS1 |
Name | carbamoyl-phosphate synthase 1, mitochondrial |
Aliases | carbamoyl-phosphate synthetase 1, mitochondrial; CPSASE1; PHN; carbamoylphosphate synthetase I; CPSase I; Ca ...... |
Chromosomal Location | 2p |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between CPS1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
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Symbol | CPS1 |
Name | carbamoyl-phosphate synthase 1, mitochondrial |
Aliases | carbamoyl-phosphate synthetase 1, mitochondrial; CPSASE1; PHN; carbamoylphosphate synthetase I; CPSase I; Ca ...... |
Chromosomal Location | 2p |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of CPS1 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | CPS1 |
Name | carbamoyl-phosphate synthase 1, mitochondrial |
Aliases | carbamoyl-phosphate synthetase 1, mitochondrial; CPSASE1; PHN; carbamoylphosphate synthetase I; CPSase I; Ca ...... |
Chromosomal Location | 2p |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of CPS1 in various data sets.
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Points in the above scatter plot represent the mutation difference of CPS1 in various data sets.
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Summary | |
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Symbol | CPS1 |
Name | carbamoyl-phosphate synthase 1, mitochondrial |
Aliases | carbamoyl-phosphate synthetase 1, mitochondrial; CPSASE1; PHN; carbamoylphosphate synthetase I; CPSase I; Ca ...... |
Chromosomal Location | 2p |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of CPS1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | CPS1 |
Name | carbamoyl-phosphate synthase 1, mitochondrial |
Aliases | carbamoyl-phosphate synthetase 1, mitochondrial; CPSASE1; PHN; carbamoylphosphate synthetase I; CPSase I; Ca ...... |
Chromosomal Location | 2p |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of CPS1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by CPS1. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | CPS1 |
Name | carbamoyl-phosphate synthase 1, mitochondrial |
Aliases | carbamoyl-phosphate synthetase 1, mitochondrial; CPSASE1; PHN; carbamoylphosphate synthetase I; CPSase I; Ca ...... |
Chromosomal Location | 2p |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of CPS1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | CPS1 |
Name | carbamoyl-phosphate synthase 1, mitochondrial |
Aliases | carbamoyl-phosphate synthetase 1, mitochondrial; CPSASE1; PHN; carbamoylphosphate synthetase I; CPSase I; Ca ...... |
Chromosomal Location | 2p |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of CPS1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | CPS1 |
Name | carbamoyl-phosphate synthase 1, mitochondrial |
Aliases | carbamoyl-phosphate synthetase 1, mitochondrial; CPSASE1; PHN; carbamoylphosphate synthetase I; CPSase I; Ca ...... |
Chromosomal Location | 2p |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between CPS1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | CPS1 |
Name | carbamoyl-phosphate synthase 1, mitochondrial |
Aliases | carbamoyl-phosphate synthetase 1, mitochondrial; CPSASE1; PHN; carbamoylphosphate synthetase I; CPSase I; Ca ...... |
Chromosomal Location | 2p |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting CPS1 collected from DrugBank database. |
Details on drugs targeting CPS1.
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