Summary | |
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Symbol | CRCP |
Name | CGRP receptor component |
Aliases | CGRP-RCP; RCP9; calcitonin gene-related peptide-receptor component protein; CGRPRCP; CGRP-receptor component ...... |
Chromosomal Location | 7q11.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Nucleus Cell membrane Peripheral membrane protein Cytoplasmic side |
Domain |
PF03874 RNA polymerase Rpb4 |
Function |
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts induce type I interferon and NF- Kappa-B through the RIG-I pathway (By similarity). ; FUNCTION: Accessory protein for the calcitonin gene-related peptide (CGRP) receptor. It modulates CGRP responsiveness in a variety of tissues. |
Biological Process |
GO:0001819 positive regulation of cytokine production GO:0006352 DNA-templated transcription, initiation GO:0006383 transcription from RNA polymerase III promoter GO:0006384 transcription initiation from RNA polymerase III promoter GO:0007218 neuropeptide signaling pathway GO:0009615 response to virus GO:0032479 regulation of type I interferon production GO:0032481 positive regulation of type I interferon production GO:0032606 type I interferon production GO:0051607 defense response to virus GO:0098542 defense response to other organism |
Molecular Function |
GO:0001056 RNA polymerase III activity GO:0001635 calcitonin gene-related peptide receptor activity GO:0001653 peptide receptor activity GO:0003899 DNA-directed RNA polymerase activity GO:0008528 G-protein coupled peptide receptor activity GO:0016779 nucleotidyltransferase activity GO:0034062 RNA polymerase activity GO:0097642 calcitonin family receptor activity |
Cellular Component |
GO:0000428 DNA-directed RNA polymerase complex GO:0001669 acrosomal vesicle GO:0005666 DNA-directed RNA polymerase III complex GO:0009360 DNA polymerase III complex GO:0030141 secretory granule GO:0030880 RNA polymerase complex GO:0042575 DNA polymerase complex GO:0055029 nuclear DNA-directed RNA polymerase complex GO:0061695 transferase complex, transferring phosphorus-containing groups GO:0097223 sperm part GO:0099503 secretory vesicle |
KEGG | - |
Reactome |
R-HSA-1834949: Cytosolic sensors of pathogen-associated DNA R-HSA-74160: Gene Expression R-HSA-168256: Immune System R-HSA-168249: Innate Immune System R-HSA-504046: RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription R-HSA-749476: RNA Polymerase III Abortive And Retractive Initiation R-HSA-73780: RNA Polymerase III Chain Elongation R-HSA-74158: RNA Polymerase III Transcription R-HSA-76046: RNA Polymerase III Transcription Initiation R-HSA-76061: RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76066: RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76071: RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-73980: RNA Polymerase III Transcription Termination |
Summary | |
---|---|
Symbol | CRCP |
Name | CGRP receptor component |
Aliases | CGRP-RCP; RCP9; calcitonin gene-related peptide-receptor component protein; CGRPRCP; CGRP-receptor component ...... |
Chromosomal Location | 7q11.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between CRCP and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | CRCP |
Name | CGRP receptor component |
Aliases | CGRP-RCP; RCP9; calcitonin gene-related peptide-receptor component protein; CGRPRCP; CGRP-receptor component ...... |
Chromosomal Location | 7q11.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of CRCP in screening data sets for detecting immune reponses.
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Summary | |
---|---|
Symbol | CRCP |
Name | CGRP receptor component |
Aliases | CGRP-RCP; RCP9; calcitonin gene-related peptide-receptor component protein; CGRPRCP; CGRP-receptor component ...... |
Chromosomal Location | 7q11.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of CRCP in various data sets.
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There is no record. |
Summary | |
---|---|
Symbol | CRCP |
Name | CGRP receptor component |
Aliases | CGRP-RCP; RCP9; calcitonin gene-related peptide-receptor component protein; CGRPRCP; CGRP-receptor component ...... |
Chromosomal Location | 7q11.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of CRCP. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | CRCP |
Name | CGRP receptor component |
Aliases | CGRP-RCP; RCP9; calcitonin gene-related peptide-receptor component protein; CGRPRCP; CGRP-receptor component ...... |
Chromosomal Location | 7q11.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of CRCP. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by CRCP. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | CRCP |
Name | CGRP receptor component |
Aliases | CGRP-RCP; RCP9; calcitonin gene-related peptide-receptor component protein; CGRPRCP; CGRP-receptor component ...... |
Chromosomal Location | 7q11.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of CRCP. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | CRCP |
Name | CGRP receptor component |
Aliases | CGRP-RCP; RCP9; calcitonin gene-related peptide-receptor component protein; CGRPRCP; CGRP-receptor component ...... |
Chromosomal Location | 7q11.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of CRCP expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | CRCP |
Name | CGRP receptor component |
Aliases | CGRP-RCP; RCP9; calcitonin gene-related peptide-receptor component protein; CGRPRCP; CGRP-receptor component ...... |
Chromosomal Location | 7q11.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between CRCP and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | CRCP |
Name | CGRP receptor component |
Aliases | CGRP-RCP; RCP9; calcitonin gene-related peptide-receptor component protein; CGRPRCP; CGRP-receptor component ...... |
Chromosomal Location | 7q11.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting CRCP collected from DrugBank database. |
There is no record. |