Browse CREB1

Summary
SymbolCREB1
NamecAMP responsive element binding protein 1
Aliases CREB; CREB-1; active transcription factor CREB; cAMP-response element-binding protein-1; cAMP-responsive ele ......
Chromosomal Location2q34
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Nucleus
Domain PF00170 bZIP transcription factor
PF02173 pKID domain
Function

Phosphorylation-dependent transcription factor that stimulates transcription upon binding to the DNA cAMP response element (CRE), a sequence present in many viral and cellular promoters. Transcription activation is enhanced by the TORC coactivators which act independently of Ser-133 phosphorylation. Involved in different cellular processes including the synchronization of circadian rhythmicity and the differentiation of adipose cells.

> Gene Ontology
 
Biological Process GO:0001101 response to acid chemical
GO:0001666 response to hypoxia
GO:0001819 positive regulation of cytokine production
GO:0002521 leukocyte differentiation
GO:0002573 myeloid leukocyte differentiation
GO:0002761 regulation of myeloid leukocyte differentiation
GO:0002763 positive regulation of myeloid leukocyte differentiation
GO:0006352 DNA-templated transcription, initiation
GO:0006367 transcription initiation from RNA polymerase II promoter
GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0007409 axonogenesis
GO:0007411 axon guidance
GO:0007507 heart development
GO:0007517 muscle organ development
GO:0007568 aging
GO:0007589 body fluid secretion
GO:0007595 lactation
GO:0007611 learning or memory
GO:0007612 learning
GO:0007613 memory
GO:0007623 circadian rhythm
GO:0007632 visual behavior
GO:0008306 associative learning
GO:0008361 regulation of cell size
GO:0008542 visual learning
GO:0009314 response to radiation
GO:0009416 response to light stimulus
GO:0009914 hormone transport
GO:0010035 response to inorganic substance
GO:0010038 response to metal ion
GO:0010043 response to zinc ion
GO:0010817 regulation of hormone levels
GO:0010944 negative regulation of transcription by competitive promoter binding
GO:0014009 glial cell proliferation
GO:0014013 regulation of gliogenesis
GO:0014706 striated muscle tissue development
GO:0014823 response to activity
GO:0016050 vesicle organization
GO:0016202 regulation of striated muscle tissue development
GO:0019216 regulation of lipid metabolic process
GO:0021536 diencephalon development
GO:0021983 pituitary gland development
GO:0023061 signal release
GO:0030099 myeloid cell differentiation
GO:0030316 osteoclast differentiation
GO:0030323 respiratory tube development
GO:0030324 lung development
GO:0030879 mammary gland development
GO:0030900 forebrain development
GO:0031334 positive regulation of protein complex assembly
GO:0031647 regulation of protein stability
GO:0032535 regulation of cellular component size
GO:0032907 transforming growth factor beta3 production
GO:0032910 regulation of transforming growth factor beta3 production
GO:0032916 positive regulation of transforming growth factor beta3 production
GO:0032941 secretion by tissue
GO:0033363 secretory granule organization
GO:0033762 response to glucagon
GO:0034670 chemotaxis to arachidonic acid
GO:0035094 response to nicotine
GO:0035264 multicellular organism growth
GO:0035270 endocrine system development
GO:0035728 response to hepatocyte growth factor
GO:0035729 cellular response to hepatocyte growth factor stimulus
GO:0036119 response to platelet-derived growth factor
GO:0036120 cellular response to platelet-derived growth factor stimulus
GO:0036293 response to decreased oxygen levels
GO:0040014 regulation of multicellular organism growth
GO:0040018 positive regulation of multicellular organism growth
GO:0042063 gliogenesis
GO:0042493 response to drug
GO:0042752 regulation of circadian rhythm
GO:0043254 regulation of protein complex assembly
GO:0043279 response to alkaloid
GO:0043434 response to peptide hormone
GO:0044089 positive regulation of cellular component biogenesis
GO:0044708 single-organism behavior
GO:0045444 fat cell differentiation
GO:0045598 regulation of fat cell differentiation
GO:0045600 positive regulation of fat cell differentiation
GO:0045637 regulation of myeloid cell differentiation
GO:0045639 positive regulation of myeloid cell differentiation
GO:0045670 regulation of osteoclast differentiation
GO:0045672 positive regulation of osteoclast differentiation
GO:0045834 positive regulation of lipid metabolic process
GO:0045844 positive regulation of striated muscle tissue development
GO:0045898 regulation of RNA polymerase II transcriptional preinitiation complex assembly
GO:0045899 positive regulation of RNA polymerase II transcriptional preinitiation complex assembly
GO:0045927 positive regulation of growth
GO:0046879 hormone secretion
GO:0046883 regulation of hormone secretion
GO:0046887 positive regulation of hormone secretion
GO:0046889 positive regulation of lipid biosynthetic process
GO:0046890 regulation of lipid biosynthetic process
GO:0048144 fibroblast proliferation
GO:0048145 regulation of fibroblast proliferation
GO:0048167 regulation of synaptic plasticity
GO:0048286 lung alveolus development
GO:0048511 rhythmic process
GO:0048634 regulation of muscle organ development
GO:0048636 positive regulation of muscle organ development
GO:0048638 regulation of developmental growth
GO:0048639 positive regulation of developmental growth
GO:0048667 cell morphogenesis involved in neuron differentiation
GO:0048732 gland development
GO:0048738 cardiac muscle tissue development
GO:0050804 modulation of synaptic transmission
GO:0050806 positive regulation of synaptic transmission
GO:0050821 protein stabilization
GO:0050878 regulation of body fluid levels
GO:0050890 cognition
GO:0051047 positive regulation of secretion
GO:0051123 RNA polymerase II transcriptional preinitiation complex assembly
GO:0055024 regulation of cardiac muscle tissue development
GO:0055025 positive regulation of cardiac muscle tissue development
GO:0060251 regulation of glial cell proliferation
GO:0060260 regulation of transcription initiation from RNA polymerase II promoter
GO:0060261 positive regulation of transcription initiation from RNA polymerase II promoter
GO:0060291 long-term synaptic potentiation
GO:0060428 lung epithelium development
GO:0060430 lung saccule development
GO:0060479 lung cell differentiation
GO:0060487 lung epithelial cell differentiation
GO:0060509 Type I pneumocyte differentiation
GO:0060537 muscle tissue development
GO:0060541 respiratory system development
GO:0061564 axon development
GO:0065004 protein-DNA complex assembly
GO:0070482 response to oxygen levels
GO:0070542 response to fatty acid
GO:0070897 DNA-templated transcriptional preinitiation complex assembly
GO:0070997 neuron death
GO:0071229 cellular response to acid chemical
GO:0071241 cellular response to inorganic substance
GO:0071248 cellular response to metal ion
GO:0071294 cellular response to zinc ion
GO:0071375 cellular response to peptide hormone stimulus
GO:0071396 cellular response to lipid
GO:0071398 cellular response to fatty acid
GO:0071417 cellular response to organonitrogen compound
GO:0071559 response to transforming growth factor beta
GO:0071560 cellular response to transforming growth factor beta stimulus
GO:0071604 transforming growth factor beta production
GO:0071634 regulation of transforming growth factor beta production
GO:0071636 positive regulation of transforming growth factor beta production
GO:0071824 protein-DNA complex subunit organization
GO:0090066 regulation of anatomical structure size
GO:0097485 neuron projection guidance
GO:1900271 regulation of long-term synaptic potentiation
GO:1900273 positive regulation of long-term synaptic potentiation
GO:1901214 regulation of neuron death
GO:1901215 negative regulation of neuron death
GO:1901652 response to peptide
GO:1901653 cellular response to peptide
GO:1901861 regulation of muscle tissue development
GO:1901863 positive regulation of muscle tissue development
GO:1902065 response to L-glutamate
GO:1902105 regulation of leukocyte differentiation
GO:1902107 positive regulation of leukocyte differentiation
GO:1903532 positive regulation of secretion by cell
GO:1903706 regulation of hemopoiesis
GO:1903708 positive regulation of hemopoiesis
GO:1990089 response to nerve growth factor
GO:1990090 cellular response to nerve growth factor stimulus
GO:1990267 response to transition metal nanoparticle
GO:1990314 cellular response to insulin-like growth factor stimulus
GO:2000142 regulation of DNA-templated transcription, initiation
GO:2000144 positive regulation of DNA-templated transcription, initiation
Molecular Function GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0000982 transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0000987 core promoter proximal region sequence-specific DNA binding
GO:0001076 transcription factor activity, RNA polymerase II transcription factor binding
GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0001085 RNA polymerase II transcription factor binding
GO:0001102 RNA polymerase II activating transcription factor binding
GO:0001158 enhancer sequence-specific DNA binding
GO:0001159 core promoter proximal region DNA binding
GO:0001190 transcriptional activator activity, RNA polymerase II transcription factor binding
GO:0001191 transcriptional repressor activity, RNA polymerase II transcription factor binding
GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
GO:0008134 transcription factor binding
GO:0030544 Hsp70 protein binding
GO:0031072 heat shock protein binding
GO:0033613 activating transcription factor binding
GO:0035035 histone acetyltransferase binding
GO:0035326 enhancer binding
GO:0035497 cAMP response element binding
GO:0098811 transcriptional repressor activity, RNA polymerase II activating transcription factor binding
GO:1990763 arrestin family protein binding
Cellular Component GO:0000785 chromatin
GO:0000790 nuclear chromatin
GO:0000791 euchromatin
GO:0005667 transcription factor complex
GO:0005719 nuclear euchromatin
GO:0005759 mitochondrial matrix
GO:0030424 axon
GO:0044454 nuclear chromosome part
GO:0044798 nuclear transcription factor complex
GO:0090575 RNA polymerase II transcription factor complex
GO:1990589 ATF4-CREB1 transcription factor complex
> KEGG and Reactome Pathway
 
KEGG hsa04022 cGMP-PKG signaling pathway
hsa04024 cAMP signaling pathway
hsa04151 PI3K-Akt signaling pathway
hsa04152 AMPK signaling pathway
hsa04261 Adrenergic signaling in cardiomyocytes
hsa04380 Osteoclast differentiation
hsa04612 Antigen processing and presentation
hsa04668 TNF signaling pathway
hsa04710 Circadian rhythm
hsa04713 Circadian entrainment
hsa04725 Cholinergic synapse
hsa04728 Dopaminergic synapse
hsa04911 Insulin secretion
hsa04915 Estrogen signaling pathway
hsa04916 Melanogenesis
hsa04918 Thyroid hormone synthesis
hsa04922 Glucagon signaling pathway
hsa04962 Vasopressin-regulated water reabsorption
Reactome R-HSA-198693: AKT phosphorylates targets in the nucleus
R-HSA-166054: Activated TLR4 signalling
R-HSA-442755: Activation of NMDA receptor upon glutamate binding and postsynaptic events
R-HSA-1280218: Adaptive Immune System
R-HSA-422475: Axon guidance
R-HSA-1368108: BMAL1
R-HSA-199920: CREB phosphorylation
R-HSA-442720: CREB phosphorylation through the activation of Adenylate Cyclase
R-HSA-442729: CREB phosphorylation through the activation of CaMKII
R-HSA-442717: CREB phosphorylation through the activation of CaMKK
R-HSA-442742: CREB phosphorylation through the activation of Ras
R-HSA-111996: Ca-dependent events
R-HSA-111997: CaM pathway
R-HSA-111932: CaMK IV-mediated phosphorylation of CREB
R-HSA-111933: Calmodulin induced events
R-HSA-400253: Circadian Clock
R-HSA-5674400: Constitutive Signaling by AKT1 E17K in Cancer
R-HSA-1489509: DAG and IP3 signaling
R-HSA-2172127: DAP12 interactions
R-HSA-2424491: DAP12 signaling
R-HSA-1266738: Developmental Biology
R-HSA-1643685: Disease
R-HSA-5663202: Diseases of signal transduction
R-HSA-186763: Downstream signal transduction
R-HSA-1168372: Downstream signaling events of B Cell Receptor (BCR)
R-HSA-212718: EGFR interacts with phospholipase C-gamma
R-HSA-2454202: Fc epsilon receptor (FCERI) signaling
R-HSA-112040: G-protein mediated events
R-HSA-180292: GAB1 signalosome
R-HSA-881907: Gastrin-CREB signalling pathway via PKC and MAPK
R-HSA-168256: Immune System
R-HSA-168249: Innate Immune System
R-HSA-450294: MAP kinase activation in TLR cascade
R-HSA-450282: MAPK targets/ Nuclear events mediated by MAP kinases
R-HSA-1592230: Mitochondrial biogenesis
R-HSA-975871: MyD88 cascade initiated on plasma membrane
R-HSA-975155: MyD88 dependent cascade initiated on endosome
R-HSA-166166: MyD88-independent TLR3/TLR4 cascade
R-HSA-166058: MyD88
R-HSA-375165: NCAM signaling for neurite out-growth
R-HSA-187037: NGF signalling via TRKA from the plasma membrane
R-HSA-2197563: NOTCH2 intracellular domain regulates transcription
R-HSA-112316: Neuronal System
R-HSA-112314: Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
R-HSA-198725: Nuclear Events (kinase and transcription factor activation)
R-HSA-111885: Opioid Signalling
R-HSA-1852241: Organelle biogenesis and maintenance
R-HSA-2219528: PI3K/AKT Signaling in Cancer
R-HSA-198203: PI3K/AKT activation
R-HSA-1257604: PIP3 activates AKT signaling
R-HSA-111931: PKA-mediated phosphorylation of CREB
R-HSA-112043: PLC beta mediated events
R-HSA-167021: PLC-gamma1 signalling
R-HSA-438064: Post NMDA receptor activation events
R-HSA-2730905: Role of LAT2/NTAL/LAB on calcium mobilization
R-HSA-162582: Signal Transduction
R-HSA-177929: Signaling by EGFR
R-HSA-372790: Signaling by GPCR
R-HSA-157118: Signaling by NOTCH
R-HSA-1980145: Signaling by NOTCH2
R-HSA-186797: Signaling by PDGF
R-HSA-1433557: Signaling by SCF-KIT
R-HSA-983705: Signaling by the B Cell Receptor (BCR)
R-HSA-166520: Signalling by NGF
R-HSA-168180: TRAF6 Mediated Induction of proinflammatory cytokines
R-HSA-975138: TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
R-HSA-937061: TRIF-mediated TLR3/TLR4 signaling
R-HSA-168142: Toll Like Receptor 10 (TLR10) Cascade
R-HSA-181438: Toll Like Receptor 2 (TLR2) Cascade
R-HSA-168164: Toll Like Receptor 3 (TLR3) Cascade
R-HSA-166016: Toll Like Receptor 4 (TLR4) Cascade
R-HSA-168176: Toll Like Receptor 5 (TLR5) Cascade
R-HSA-168181: Toll Like Receptor 7/8 (TLR7/8) Cascade
R-HSA-168138: Toll Like Receptor 9 (TLR9) Cascade
R-HSA-168179: Toll Like Receptor TLR1
R-HSA-168188: Toll Like Receptor TLR6
R-HSA-168898: Toll-Like Receptors Cascades
R-HSA-2151201: Transcriptional activation of mitochondrial biogenesis
R-HSA-112315: Transmission across Chemical Synapses
Summary
SymbolCREB1
NamecAMP responsive element binding protein 1
Aliases CREB; CREB-1; active transcription factor CREB; cAMP-response element-binding protein-1; cAMP-responsive ele ......
Chromosomal Location2q34
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between CREB1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 
  Literatures describing the relation between CREB1 and anti-tumor immunity in human cancer.
PMID Cancer type Relation to immunity Evidence sentences
26091714Lung CarcinomaInhibit immunity (T cell function)Ectopic expression of CREB enhanced the transcriptional activity of the 5′ flanking sequence of miR-9-1, and mutation of the binding site for CREB abolished the enhancive effect of CREB. In this study, we found that inhibition of microRNA (miR)-9 promoted the differentiation of MDSCs with significantly reduced immunosuppressive function whereas overexpression of miR-9 markedly enhanced the function of MDSCs.
21972292MelanomaInhibit immunityIn accordance with previous findings,44,45 we found that miR-17 inhibits TGF- signaling through targeting TGF RII. Biochemically, the reduction of either CREB1 or TGF RII is not dramatic, but the impacts from these moderate adjustments on T-cell function are not negligible.
Summary
SymbolCREB1
NamecAMP responsive element binding protein 1
Aliases CREB; CREB-1; active transcription factor CREB; cAMP-response element-binding protein-1; cAMP-responsive ele ......
Chromosomal Location2q34
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of CREB1 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell logFC: -3.40; FDR: 0.00700 Resistant to T cell-mediated killing
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NS NA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NS NA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NS NA/NS
24476824shRNAmelanomaB16Primary screen NA/NS NA/NS
24476824shRNAmelanomaB16Secondary screen NA/NS NA/NS
Summary
SymbolCREB1
NamecAMP responsive element binding protein 1
Aliases CREB; CREB-1; active transcription factor CREB; cAMP-response element-binding protein-1; cAMP-responsive ele ......
Chromosomal Location2q34
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of CREB1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14120.0390.873
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)650.0420.973
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)870.0370.968
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.0120.975
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.2850.865
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.3340.875
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.0130.971
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.010.995
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.0030.999
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 48-0.1060.926
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.6520.688
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.0040.919
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of CREB1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 277302.7-2.71
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 275903.4-3.41
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21170001
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91622.2022.20.12
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59200200.357
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47250250.364
1329033130MelanomaallAnti-PD-1 (nivolumab) 38272.602.61
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22134.504.51
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolCREB1
NamecAMP responsive element binding protein 1
Aliases CREB; CREB-1; active transcription factor CREB; cAMP-response element-binding protein-1; cAMP-responsive ele ......
Chromosomal Location2q34
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of CREB1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolCREB1
NamecAMP responsive element binding protein 1
Aliases CREB; CREB-1; active transcription factor CREB; cAMP-response element-binding protein-1; cAMP-responsive ele ......
Chromosomal Location2q34
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of CREB1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by CREB1.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolCREB1
NamecAMP responsive element binding protein 1
Aliases CREB; CREB-1; active transcription factor CREB; cAMP-response element-binding protein-1; cAMP-responsive ele ......
Chromosomal Location2q34
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of CREB1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolCREB1
NamecAMP responsive element binding protein 1
Aliases CREB; CREB-1; active transcription factor CREB; cAMP-response element-binding protein-1; cAMP-responsive ele ......
Chromosomal Location2q34
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of CREB1 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolCREB1
NamecAMP responsive element binding protein 1
Aliases CREB; CREB-1; active transcription factor CREB; cAMP-response element-binding protein-1; cAMP-responsive ele ......
Chromosomal Location2q34
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between CREB1 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolCREB1
NamecAMP responsive element binding protein 1
Aliases CREB; CREB-1; active transcription factor CREB; cAMP-response element-binding protein-1; cAMP-responsive ele ......
Chromosomal Location2q34
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting CREB1 collected from DrugBank database.
> Drugs from DrugBank database
 

  Details on drugs targeting CREB1.
ID Name Drug Type Targets #Targets
DB00131Adenosine monophosphateSmall MoleculeACSL1, ACSS1, ACSS2, ADCY1, ADK, CREB1, FBP1, HINT1, PDE4B, PDE4D, ......15
DB01183NaloxoneSmall MoleculeCES1, CREB1, ESR1, OPRD1, OPRK1, OPRM1, TLR47