Browse CREB3L2

Summary
SymbolCREB3L2
NamecAMP responsive element binding protein 3-like 2
Aliases BBF2H7; TCAG_1951439; B-ZIB transcription factor; BBF2 human homolog on chromosome 7; FUS/BBF2H7 protein; ba ......
Chromosomal Location7q34
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Endoplasmic reticulum membrane Single-pass type II membrane protein. Note=ER membrane resident protein. Upon ER stress, translocated to the Golgi apparatus where it is cleaved. The cytosolic N-terminal fragment (processed cyclic AMP-responsive element-binding protein 3-like protein 1) is transported into the nucleus. ; SUBCELLULAR LOCATION: Processed cyclic AMP-responsive element-binding protein 3-like protein 2: Nucleus. Note=Upon ER stress, translocated into the nucleus.
Domain PF00170 bZIP transcription factor
Function

Transcription factor involved in unfolded protein response (UPR). In the absence of endoplasmic reticulum (ER) stress, inserted into ER membranes, with N-terminal DNA-binding and transcription activation domains oriented toward the cytosolic face of the membrane. In response to ER stress, transported to the Golgi, where it is cleaved in a site-specific manner by resident proteases S1P/MBTPS1 and S2P/MBTPS2. The released N-terminal cytosolic domain is translocated to the nucleus to effect transcription of specific target genes. Plays a critical role in chondrogenesis by activating the transcription of SEC23A, which promotes the transport and secretion of cartilage matrix proteins, and possibly that of ER biogenesis-related genes (By similarity). In a neuroblastoma cell line, protects cells from ER stress-induced death (PubMed:17178827). In vitro activates transcription of target genes via direct binding to the CRE site (PubMed:17178827).

> Gene Ontology
 
Biological Process GO:0001501 skeletal system development
GO:0002062 chondrocyte differentiation
GO:0006888 ER to Golgi vesicle-mediated transport
GO:0006986 response to unfolded protein
GO:0030968 endoplasmic reticulum unfolded protein response
GO:0034620 cellular response to unfolded protein
GO:0034976 response to endoplasmic reticulum stress
GO:0035966 response to topologically incorrect protein
GO:0035967 cellular response to topologically incorrect protein
GO:0048193 Golgi vesicle transport
GO:0051216 cartilage development
GO:0061448 connective tissue development
Molecular Function GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000982 transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0000987 core promoter proximal region sequence-specific DNA binding
GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0001159 core promoter proximal region DNA binding
GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
GO:0035497 cAMP response element binding
Cellular Component -
> KEGG and Reactome Pathway
 
KEGG hsa04022 cGMP-PKG signaling pathway
hsa04024 cAMP signaling pathway
hsa04151 PI3K-Akt signaling pathway
hsa04152 AMPK signaling pathway
hsa04261 Adrenergic signaling in cardiomyocytes
hsa04668 TNF signaling pathway
hsa04725 Cholinergic synapse
hsa04728 Dopaminergic synapse
hsa04911 Insulin secretion
hsa04915 Estrogen signaling pathway
hsa04916 Melanogenesis
hsa04918 Thyroid hormone synthesis
hsa04922 Glucagon signaling pathway
hsa04962 Vasopressin-regulated water reabsorption
Reactome -
Summary
SymbolCREB3L2
NamecAMP responsive element binding protein 3-like 2
Aliases BBF2H7; TCAG_1951439; B-ZIB transcription factor; BBF2 human homolog on chromosome 7; FUS/BBF2H7 protein; ba ......
Chromosomal Location7q34
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between CREB3L2 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.

Summary
SymbolCREB3L2
NamecAMP responsive element binding protein 3-like 2
Aliases BBF2H7; TCAG_1951439; B-ZIB transcription factor; BBF2 human homolog on chromosome 7; FUS/BBF2H7 protein; ba ......
Chromosomal Location7q34
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of CREB3L2 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell logFC: 0.98; FDR: 0.021200 Sensitive to T cell-mediated killing
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NS NA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NS NA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NS NA/NS
24476824shRNAmelanomaB16Primary screen NA/NS NA/NS
24476824shRNAmelanomaB16Secondary screen NA/NS NA/NS
Summary
SymbolCREB3L2
NamecAMP responsive element binding protein 3-like 2
Aliases BBF2H7; TCAG_1951439; B-ZIB transcription factor; BBF2 human homolog on chromosome 7; FUS/BBF2H7 protein; ba ......
Chromosomal Location7q34
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of CREB3L2 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.2190.527
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)650.250.902
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.5630.712
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.1880.543
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.1250.955
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47-0.270.921
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.2510.564
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-0.0640.973
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.6360.762
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.5890.613
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 281.0950.537
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.0490.613
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of CREB3L2 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27737.42.74.70.294
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27597.43.440.587
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21174.804.81
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13117.707.71
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91611.1011.10.36
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47250250.364
1329033130MelanomaallAnti-PD-1 (nivolumab) 38270001
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22130001
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolCREB3L2
NamecAMP responsive element binding protein 3-like 2
Aliases BBF2H7; TCAG_1951439; B-ZIB transcription factor; BBF2 human homolog on chromosome 7; FUS/BBF2H7 protein; ba ......
Chromosomal Location7q34
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of CREB3L2. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolCREB3L2
NamecAMP responsive element binding protein 3-like 2
Aliases BBF2H7; TCAG_1951439; B-ZIB transcription factor; BBF2 human homolog on chromosome 7; FUS/BBF2H7 protein; ba ......
Chromosomal Location7q34
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of CREB3L2. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by CREB3L2.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolCREB3L2
NamecAMP responsive element binding protein 3-like 2
Aliases BBF2H7; TCAG_1951439; B-ZIB transcription factor; BBF2 human homolog on chromosome 7; FUS/BBF2H7 protein; ba ......
Chromosomal Location7q34
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of CREB3L2. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolCREB3L2
NamecAMP responsive element binding protein 3-like 2
Aliases BBF2H7; TCAG_1951439; B-ZIB transcription factor; BBF2 human homolog on chromosome 7; FUS/BBF2H7 protein; ba ......
Chromosomal Location7q34
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of CREB3L2 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolCREB3L2
NamecAMP responsive element binding protein 3-like 2
Aliases BBF2H7; TCAG_1951439; B-ZIB transcription factor; BBF2 human homolog on chromosome 7; FUS/BBF2H7 protein; ba ......
Chromosomal Location7q34
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between CREB3L2 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolCREB3L2
NamecAMP responsive element binding protein 3-like 2
Aliases BBF2H7; TCAG_1951439; B-ZIB transcription factor; BBF2 human homolog on chromosome 7; FUS/BBF2H7 protein; ba ......
Chromosomal Location7q34
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting CREB3L2 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.