Browse CRLF1

Summary
SymbolCRLF1
Namecytokine receptor-like factor 1
Aliases CLF-1; CISS; CISS1; cold-induced sweating syndrome; zcytor5; cytokine type 1 receptor CRLP-1; cytokine-like ......
Chromosomal Location19p12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Secreted
Domain PF09067 Erythropoietin receptor
PF00041 Fibronectin type III domain
Function

Cytokine receptor subunit, possibly playing a regulatory role in the immune system and during fetal development. May be involved in nervous system development.

> Gene Ontology
 
Biological Process GO:0001655 urogenital system development
GO:0001657 ureteric bud development
GO:0001822 kidney development
GO:0001823 mesonephros development
GO:0007259 JAK-STAT cascade
GO:0007260 tyrosine phosphorylation of STAT protein
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0018212 peptidyl-tyrosine modification
GO:0042503 tyrosine phosphorylation of Stat3 protein
GO:0042509 regulation of tyrosine phosphorylation of STAT protein
GO:0042516 regulation of tyrosine phosphorylation of Stat3 protein
GO:0042517 positive regulation of tyrosine phosphorylation of Stat3 protein
GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein
GO:0043523 regulation of neuron apoptotic process
GO:0043524 negative regulation of neuron apoptotic process
GO:0046425 regulation of JAK-STAT cascade
GO:0046427 positive regulation of JAK-STAT cascade
GO:0050730 regulation of peptidyl-tyrosine phosphorylation
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0051402 neuron apoptotic process
GO:0070997 neuron death
GO:0072001 renal system development
GO:0072073 kidney epithelium development
GO:0072163 mesonephric epithelium development
GO:0072164 mesonephric tubule development
GO:0097049 motor neuron apoptotic process
GO:0097696 STAT cascade
GO:1901214 regulation of neuron death
GO:1901215 negative regulation of neuron death
GO:1904892 regulation of STAT cascade
GO:1904894 positive regulation of STAT cascade
GO:2000671 regulation of motor neuron apoptotic process
GO:2000672 negative regulation of motor neuron apoptotic process
Molecular Function GO:0005125 cytokine activity
GO:0005126 cytokine receptor binding
GO:0005127 ciliary neurotrophic factor receptor binding
GO:0019955 cytokine binding
GO:0046982 protein heterodimerization activity
Cellular Component GO:0097058 CRLF-CLCF1 complex
> KEGG and Reactome Pathway
 
KEGG -
Reactome R-HSA-1280215: Cytokine Signaling in Immune system
R-HSA-6788467: IL-6-type cytokine receptor ligand interactions
R-HSA-168256: Immune System
R-HSA-6783589: Interleukin-6 family signaling
R-HSA-449147: Signaling by Interleukins
Summary
SymbolCRLF1
Namecytokine receptor-like factor 1
Aliases CLF-1; CISS; CISS1; cold-induced sweating syndrome; zcytor5; cytokine type 1 receptor CRLP-1; cytokine-like ......
Chromosomal Location19p12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between CRLF1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.

Summary
SymbolCRLF1
Namecytokine receptor-like factor 1
Aliases CLF-1; CISS; CISS1; cold-induced sweating syndrome; zcytor5; cytokine type 1 receptor CRLP-1; cytokine-like ......
Chromosomal Location19p12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of CRLF1 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolCRLF1
Namecytokine receptor-like factor 1
Aliases CLF-1; CISS; CISS1; cold-induced sweating syndrome; zcytor5; cytokine type 1 receptor CRLP-1; cytokine-like ......
Chromosomal Location19p12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of CRLF1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-1.5570.00168
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-3.1721.44e-05
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.3890.619
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.2670.463
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.4780.715
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.0030.999
729033130MelanomaallAnti-PD-1 (nivolumab) 2623-0.760.236
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-0.4030.669
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-1.0470.31
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.6280.624
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 281.5640.339
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-1.0140.000903
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of CRLF1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 141705.9-5.91
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 41407.1-7.11
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27730001
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27590001
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21170001
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916012.5-12.50.52
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59011.1-11.11
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47014.3-14.31
1329033130MelanomaallAnti-PD-1 (nivolumab) 38270001
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22130001
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolCRLF1
Namecytokine receptor-like factor 1
Aliases CLF-1; CISS; CISS1; cold-induced sweating syndrome; zcytor5; cytokine type 1 receptor CRLP-1; cytokine-like ......
Chromosomal Location19p12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of CRLF1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolCRLF1
Namecytokine receptor-like factor 1
Aliases CLF-1; CISS; CISS1; cold-induced sweating syndrome; zcytor5; cytokine type 1 receptor CRLP-1; cytokine-like ......
Chromosomal Location19p12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of CRLF1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by CRLF1.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolCRLF1
Namecytokine receptor-like factor 1
Aliases CLF-1; CISS; CISS1; cold-induced sweating syndrome; zcytor5; cytokine type 1 receptor CRLP-1; cytokine-like ......
Chromosomal Location19p12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of CRLF1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolCRLF1
Namecytokine receptor-like factor 1
Aliases CLF-1; CISS; CISS1; cold-induced sweating syndrome; zcytor5; cytokine type 1 receptor CRLP-1; cytokine-like ......
Chromosomal Location19p12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of CRLF1 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolCRLF1
Namecytokine receptor-like factor 1
Aliases CLF-1; CISS; CISS1; cold-induced sweating syndrome; zcytor5; cytokine type 1 receptor CRLP-1; cytokine-like ......
Chromosomal Location19p12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between CRLF1 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolCRLF1
Namecytokine receptor-like factor 1
Aliases CLF-1; CISS; CISS1; cold-induced sweating syndrome; zcytor5; cytokine type 1 receptor CRLP-1; cytokine-like ......
Chromosomal Location19p12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting CRLF1 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.