Summary | |
---|---|
Symbol | CRP |
Name | C-reactive protein, pentraxin-related |
Aliases | pentraxin 1; C-reactive protein |
Chromosomal Location | 1q23.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Secreted. |
Domain |
PF00354 Pentaxin family |
Function |
Displays several functions associated with host defense: it promotes agglutination, bacterial capsular swelling, phagocytosis and complement fixation through its calcium-dependent binding to phosphorylcholine. Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells. |
Biological Process |
GO:0002526 acute inflammatory response GO:0003013 circulatory system process GO:0003018 vascular process in circulatory system GO:0006801 superoxide metabolic process GO:0006909 phagocytosis GO:0006953 acute-phase response GO:0008015 blood circulation GO:0008228 opsonization GO:0009306 protein secretion GO:0010742 macrophage derived foam cell differentiation GO:0010743 regulation of macrophage derived foam cell differentiation GO:0010745 negative regulation of macrophage derived foam cell differentiation GO:0010876 lipid localization GO:0010883 regulation of lipid storage GO:0010888 negative regulation of lipid storage GO:0019915 lipid storage GO:0032637 interleukin-8 production GO:0032677 regulation of interleukin-8 production GO:0032928 regulation of superoxide anion generation GO:0032930 positive regulation of superoxide anion generation GO:0035150 regulation of tube size GO:0042311 vasodilation GO:0042312 regulation of vasodilation GO:0042554 superoxide anion generation GO:0042742 defense response to bacterium GO:0044057 regulation of system process GO:0045908 negative regulation of vasodilation GO:0050663 cytokine secretion GO:0050707 regulation of cytokine secretion GO:0050708 regulation of protein secretion GO:0050830 defense response to Gram-positive bacterium GO:0050880 regulation of blood vessel size GO:0051235 maintenance of location GO:0072593 reactive oxygen species metabolic process GO:0072606 interleukin-8 secretion GO:0090066 regulation of anatomical structure size GO:0090077 foam cell differentiation GO:0090322 regulation of superoxide metabolic process GO:0098542 defense response to other organism GO:1903522 regulation of blood circulation GO:1903523 negative regulation of blood circulation GO:2000377 regulation of reactive oxygen species metabolic process GO:2000379 positive regulation of reactive oxygen species metabolic process GO:2000482 regulation of interleukin-8 secretion |
Molecular Function |
GO:0001846 opsonin binding GO:0001848 complement binding GO:0001849 complement component C1q binding GO:0030169 low-density lipoprotein particle binding GO:0033265 choline binding GO:0050750 low-density lipoprotein particle receptor binding GO:0070325 lipoprotein particle receptor binding GO:0070405 ammonium ion binding GO:0071813 lipoprotein particle binding GO:0071814 protein-lipid complex binding |
Cellular Component | - |
KEGG | - |
Reactome |
R-HSA-173623: Classical antibody-mediated complement activation R-HSA-166658: Complement cascade R-HSA-166786: Creation of C4 and C2 activators R-HSA-168256: Immune System R-HSA-166663: Initial triggering of complement R-HSA-168249: Innate Immune System |
Summary | |
---|---|
Symbol | CRP |
Name | C-reactive protein, pentraxin-related |
Aliases | pentraxin 1; C-reactive protein |
Chromosomal Location | 1q23.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between CRP and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between CRP and anti-tumor immunity in human cancer.
|
Summary | |
---|---|
Symbol | CRP |
Name | C-reactive protein, pentraxin-related |
Aliases | pentraxin 1; C-reactive protein |
Chromosomal Location | 1q23.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
[ TOP ]
|
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Statistical results of CRP in screening data sets for detecting immune reponses.
|
Summary | |
---|---|
Symbol | CRP |
Name | C-reactive protein, pentraxin-related |
Aliases | pentraxin 1; C-reactive protein |
Chromosomal Location | 1q23.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of CRP in various data sets.
|
Points in the above scatter plot represent the mutation difference of CRP in various data sets.
|
Summary | |
---|---|
Symbol | CRP |
Name | C-reactive protein, pentraxin-related |
Aliases | pentraxin 1; C-reactive protein |
Chromosomal Location | 1q23.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of CRP. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | CRP |
Name | C-reactive protein, pentraxin-related |
Aliases | pentraxin 1; C-reactive protein |
Chromosomal Location | 1q23.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of CRP. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by CRP. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | CRP |
Name | C-reactive protein, pentraxin-related |
Aliases | pentraxin 1; C-reactive protein |
Chromosomal Location | 1q23.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of CRP. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | CRP |
Name | C-reactive protein, pentraxin-related |
Aliases | pentraxin 1; C-reactive protein |
Chromosomal Location | 1q23.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of CRP expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | CRP |
Name | C-reactive protein, pentraxin-related |
Aliases | pentraxin 1; C-reactive protein |
Chromosomal Location | 1q23.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between CRP and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | CRP |
Name | C-reactive protein, pentraxin-related |
Aliases | pentraxin 1; C-reactive protein |
Chromosomal Location | 1q23.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting CRP collected from DrugBank database. |
Details on drugs targeting CRP.
|