Summary | |
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Symbol | CRTAM |
Name | cytotoxic and regulatory T cell molecule |
Aliases | CD355; class I MHC restricted T cell associated molecule; class-I MHC-restricted T cell associated molecule; ...... |
Chromosomal Location | 11q24.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Membrane Single-pass type I membrane protein |
Domain |
PF08205 CD80-like C2-set immunoglobulin domain PF07686 Immunoglobulin V-set domain |
Function |
Interaction with CADM1 promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM3 in vivo. |
Biological Process |
GO:0001819 positive regulation of cytokine production GO:0001906 cell killing GO:0001909 leukocyte mediated cytotoxicity GO:0001910 regulation of leukocyte mediated cytotoxicity GO:0001912 positive regulation of leukocyte mediated cytotoxicity GO:0002228 natural killer cell mediated immunity GO:0002347 response to tumor cell GO:0002355 detection of tumor cell GO:0002418 immune response to tumor cell GO:0002420 natural killer cell mediated cytotoxicity directed against tumor cell target GO:0002423 natural killer cell mediated immune response to tumor cell GO:0002443 leukocyte mediated immunity GO:0002449 lymphocyte mediated immunity GO:0002697 regulation of immune effector process GO:0002699 positive regulation of immune effector process GO:0002703 regulation of leukocyte mediated immunity GO:0002705 positive regulation of leukocyte mediated immunity GO:0002706 regulation of lymphocyte mediated immunity GO:0002708 positive regulation of lymphocyte mediated immunity GO:0002715 regulation of natural killer cell mediated immunity GO:0002717 positive regulation of natural killer cell mediated immunity GO:0002831 regulation of response to biotic stimulus GO:0002833 positive regulation of response to biotic stimulus GO:0002834 regulation of response to tumor cell GO:0002836 positive regulation of response to tumor cell GO:0002837 regulation of immune response to tumor cell GO:0002839 positive regulation of immune response to tumor cell GO:0002855 regulation of natural killer cell mediated immune response to tumor cell GO:0002857 positive regulation of natural killer cell mediated immune response to tumor cell GO:0002858 regulation of natural killer cell mediated cytotoxicity directed against tumor cell target GO:0002860 positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules GO:0008037 cell recognition GO:0009306 protein secretion GO:0009595 detection of biotic stimulus GO:0031341 regulation of cell killing GO:0031343 positive regulation of cell killing GO:0031349 positive regulation of defense response GO:0042267 natural killer cell mediated cytotoxicity GO:0042269 regulation of natural killer cell mediated cytotoxicity GO:0045088 regulation of innate immune response GO:0045089 positive regulation of innate immune response GO:0045954 positive regulation of natural killer cell mediated cytotoxicity GO:0050663 cytokine secretion GO:0050707 regulation of cytokine secretion GO:0050708 regulation of protein secretion GO:0050714 positive regulation of protein secretion GO:0050715 positive regulation of cytokine secretion GO:0051047 positive regulation of secretion GO:0051222 positive regulation of protein transport GO:0098742 cell-cell adhesion via plasma-membrane adhesion molecules GO:1903532 positive regulation of secretion by cell GO:1904951 positive regulation of establishment of protein localization |
Molecular Function |
GO:0050839 cell adhesion molecule binding |
Cellular Component |
GO:0005913 cell-cell adherens junction |
KEGG | - |
Reactome |
R-HSA-1280218: Adaptive Immune System R-HSA-168256: Immune System R-HSA-198933: Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
Summary | |
---|---|
Symbol | CRTAM |
Name | cytotoxic and regulatory T cell molecule |
Aliases | CD355; class I MHC restricted T cell associated molecule; class-I MHC-restricted T cell associated molecule; ...... |
Chromosomal Location | 11q24.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between CRTAM and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between CRTAM and anti-tumor immunity in human cancer.
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Summary | |
---|---|
Symbol | CRTAM |
Name | cytotoxic and regulatory T cell molecule |
Aliases | CD355; class I MHC restricted T cell associated molecule; class-I MHC-restricted T cell associated molecule; ...... |
Chromosomal Location | 11q24.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of CRTAM in screening data sets for detecting immune reponses.
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Summary | |
---|---|
Symbol | CRTAM |
Name | cytotoxic and regulatory T cell molecule |
Aliases | CD355; class I MHC restricted T cell associated molecule; class-I MHC-restricted T cell associated molecule; ...... |
Chromosomal Location | 11q24.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of CRTAM in various data sets.
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Points in the above scatter plot represent the mutation difference of CRTAM in various data sets.
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Summary | |
---|---|
Symbol | CRTAM |
Name | cytotoxic and regulatory T cell molecule |
Aliases | CD355; class I MHC restricted T cell associated molecule; class-I MHC-restricted T cell associated molecule; ...... |
Chromosomal Location | 11q24.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of CRTAM. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | CRTAM |
Name | cytotoxic and regulatory T cell molecule |
Aliases | CD355; class I MHC restricted T cell associated molecule; class-I MHC-restricted T cell associated molecule; ...... |
Chromosomal Location | 11q24.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of CRTAM. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by CRTAM. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | CRTAM |
Name | cytotoxic and regulatory T cell molecule |
Aliases | CD355; class I MHC restricted T cell associated molecule; class-I MHC-restricted T cell associated molecule; ...... |
Chromosomal Location | 11q24.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of CRTAM. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | CRTAM |
Name | cytotoxic and regulatory T cell molecule |
Aliases | CD355; class I MHC restricted T cell associated molecule; class-I MHC-restricted T cell associated molecule; ...... |
Chromosomal Location | 11q24.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of CRTAM expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | CRTAM |
Name | cytotoxic and regulatory T cell molecule |
Aliases | CD355; class I MHC restricted T cell associated molecule; class-I MHC-restricted T cell associated molecule; ...... |
Chromosomal Location | 11q24.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between CRTAM and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | CRTAM |
Name | cytotoxic and regulatory T cell molecule |
Aliases | CD355; class I MHC restricted T cell associated molecule; class-I MHC-restricted T cell associated molecule; ...... |
Chromosomal Location | 11q24.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting CRTAM collected from DrugBank database. |
There is no record. |