Summary | |
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Symbol | CRYAB |
Name | crystallin, alpha B |
Aliases | HSPB5; CRYA2; CMD1II; CTPP2; CTRCT16; HEL-S-101; MFM2; epididymis secretory protein Li 101; heat shock prote ...... |
Chromosomal Location | 11q23.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cytoplasm Nucleus Note=Translocates to the nucleus during heat shock and resides in sub-nuclear structures known as SC35 speckles or nuclear splicing speckles (PubMed:19464326). Localizes at the Z-bands and the intercalated disk in cardiomyocytes (PubMed:28493373). |
Domain |
PF00525 Alpha crystallin A chain PF00011 Hsp20/alpha crystallin family |
Function |
May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions. |
Biological Process |
GO:0000226 microtubule cytoskeleton organization GO:0000302 response to reactive oxygen species GO:0001558 regulation of cell growth GO:0001654 eye development GO:0001666 response to hypoxia GO:0002088 lens development in camera-type eye GO:0003012 muscle system process GO:0006457 protein folding GO:0006936 muscle contraction GO:0006979 response to oxidative stress GO:0007021 tubulin complex assembly GO:0007423 sensory organ development GO:0007517 muscle organ development GO:0007568 aging GO:0009266 response to temperature stimulus GO:0009314 response to radiation GO:0009408 response to heat GO:0010035 response to inorganic substance GO:0010212 response to ionizing radiation GO:0010332 response to gamma radiation GO:0010466 negative regulation of peptidase activity GO:0010951 negative regulation of endopeptidase activity GO:0016049 cell growth GO:0030308 negative regulation of cell growth GO:0031098 stress-activated protein kinase signaling cascade GO:0031109 microtubule polymerization or depolymerization GO:0032355 response to estradiol GO:0032386 regulation of intracellular transport GO:0032387 negative regulation of intracellular transport GO:0034605 cellular response to heat GO:0036293 response to decreased oxygen levels GO:0042542 response to hydrogen peroxide GO:0043010 camera-type eye development GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0045861 negative regulation of proteolysis GO:0045926 negative regulation of growth GO:0051051 negative regulation of transport GO:0051259 protein oligomerization GO:0051260 protein homooligomerization GO:0051346 negative regulation of hydrolase activity GO:0051403 stress-activated MAPK cascade GO:0052547 regulation of peptidase activity GO:0052548 regulation of endopeptidase activity GO:0060561 apoptotic process involved in morphogenesis GO:0070482 response to oxygen levels GO:0071214 cellular response to abiotic stimulus GO:0071478 cellular response to radiation GO:0071479 cellular response to ionizing radiation GO:0071480 cellular response to gamma radiation GO:0072593 reactive oxygen species metabolic process GO:1900034 regulation of cellular response to heat GO:1902742 apoptotic process involved in development GO:2000116 regulation of cysteine-type endopeptidase activity GO:2000117 negative regulation of cysteine-type endopeptidase activity GO:2000377 regulation of reactive oxygen species metabolic process GO:2000378 negative regulation of reactive oxygen species metabolic process |
Molecular Function |
GO:0005212 structural constituent of eye lens GO:0008017 microtubule binding GO:0015631 tubulin binding GO:0051082 unfolded protein binding |
Cellular Component |
GO:0014069 postsynaptic density GO:0015629 actin cytoskeleton GO:0030016 myofibril GO:0030017 sarcomere GO:0030018 Z disc GO:0030424 axon GO:0030425 dendrite GO:0031430 M band GO:0031672 A band GO:0031674 I band GO:0032432 actin filament bundle GO:0043025 neuronal cell body GO:0043197 dendritic spine GO:0043204 perikaryon GO:0043209 myelin sheath GO:0043292 contractile fiber GO:0044297 cell body GO:0044309 neuron spine GO:0044449 contractile fiber part GO:0060076 excitatory synapse GO:0097060 synaptic membrane GO:0097512 cardiac myofibril GO:0098794 postsynapse GO:0099572 postsynaptic specialization |
KEGG |
hsa04141 Protein processing in endoplasmic reticulum |
Reactome | - |
Summary | |
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Symbol | CRYAB |
Name | crystallin, alpha B |
Aliases | HSPB5; CRYA2; CMD1II; CTPP2; CTRCT16; HEL-S-101; MFM2; epididymis secretory protein Li 101; heat shock prote ...... |
Chromosomal Location | 11q23.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between CRYAB and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | CRYAB |
Name | crystallin, alpha B |
Aliases | HSPB5; CRYA2; CMD1II; CTPP2; CTRCT16; HEL-S-101; MFM2; epididymis secretory protein Li 101; heat shock prote ...... |
Chromosomal Location | 11q23.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of CRYAB in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | CRYAB |
Name | crystallin, alpha B |
Aliases | HSPB5; CRYA2; CMD1II; CTPP2; CTRCT16; HEL-S-101; MFM2; epididymis secretory protein Li 101; heat shock prote ...... |
Chromosomal Location | 11q23.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of CRYAB in various data sets.
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Points in the above scatter plot represent the mutation difference of CRYAB in various data sets.
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Summary | |
---|---|
Symbol | CRYAB |
Name | crystallin, alpha B |
Aliases | HSPB5; CRYA2; CMD1II; CTPP2; CTRCT16; HEL-S-101; MFM2; epididymis secretory protein Li 101; heat shock prote ...... |
Chromosomal Location | 11q23.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of CRYAB. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | CRYAB |
Name | crystallin, alpha B |
Aliases | HSPB5; CRYA2; CMD1II; CTPP2; CTRCT16; HEL-S-101; MFM2; epididymis secretory protein Li 101; heat shock prote ...... |
Chromosomal Location | 11q23.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of CRYAB. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by CRYAB. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | CRYAB |
Name | crystallin, alpha B |
Aliases | HSPB5; CRYA2; CMD1II; CTPP2; CTRCT16; HEL-S-101; MFM2; epididymis secretory protein Li 101; heat shock prote ...... |
Chromosomal Location | 11q23.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of CRYAB. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | CRYAB |
Name | crystallin, alpha B |
Aliases | HSPB5; CRYA2; CMD1II; CTPP2; CTRCT16; HEL-S-101; MFM2; epididymis secretory protein Li 101; heat shock prote ...... |
Chromosomal Location | 11q23.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of CRYAB expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | CRYAB |
Name | crystallin, alpha B |
Aliases | HSPB5; CRYA2; CMD1II; CTPP2; CTRCT16; HEL-S-101; MFM2; epididymis secretory protein Li 101; heat shock prote ...... |
Chromosomal Location | 11q23.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between CRYAB and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | CRYAB |
Name | crystallin, alpha B |
Aliases | HSPB5; CRYA2; CMD1II; CTPP2; CTRCT16; HEL-S-101; MFM2; epididymis secretory protein Li 101; heat shock prote ...... |
Chromosomal Location | 11q23.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting CRYAB collected from DrugBank database. |
There is no record. |