Summary | |
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Symbol | CSF1 |
Name | colony stimulating factor 1 (macrophage) |
Aliases | M-CSF; MCSF; MGC31930; CSF-1; lanimostim; Macrophage colony-stimulating factor 1 |
Chromosomal Location | 1p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cell membrane Single-pass type I membrane protein ; SUBCELLULAR LOCATION: Processed macrophage colony-stimulating factor 1: Secreted, extracellular space. |
Domain |
PF05337 Macrophage colony stimulating factor-1 (CSF-1) |
Function |
Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female fertility. Promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration. Plays a role in lipoprotein clearance. |
Biological Process |
GO:0001503 ossification GO:0001763 morphogenesis of a branching structure GO:0001894 tissue homeostasis GO:0001952 regulation of cell-matrix adhesion GO:0001954 positive regulation of cell-matrix adhesion GO:0001959 regulation of cytokine-mediated signaling pathway GO:0001961 positive regulation of cytokine-mediated signaling pathway GO:0002158 osteoclast proliferation GO:0002274 myeloid leukocyte activation GO:0002521 leukocyte differentiation GO:0002573 myeloid leukocyte differentiation GO:0002685 regulation of leukocyte migration GO:0002687 positive regulation of leukocyte migration GO:0002688 regulation of leukocyte chemotaxis GO:0002690 positive regulation of leukocyte chemotaxis GO:0002761 regulation of myeloid leukocyte differentiation GO:0002763 positive regulation of myeloid leukocyte differentiation GO:0007160 cell-matrix adhesion GO:0007265 Ras protein signal transduction GO:0008347 glial cell migration GO:0010720 positive regulation of cell development GO:0010742 macrophage derived foam cell differentiation GO:0010743 regulation of macrophage derived foam cell differentiation GO:0010744 positive regulation of macrophage derived foam cell differentiation GO:0010758 regulation of macrophage chemotaxis GO:0010759 positive regulation of macrophage chemotaxis GO:0010810 regulation of cell-substrate adhesion GO:0010811 positive regulation of cell-substrate adhesion GO:0014013 regulation of gliogenesis GO:0014015 positive regulation of gliogenesis GO:0022612 gland morphogenesis GO:0030099 myeloid cell differentiation GO:0030224 monocyte differentiation GO:0030225 macrophage differentiation GO:0030278 regulation of ossification GO:0030316 osteoclast differentiation GO:0030335 positive regulation of cell migration GO:0030595 leukocyte chemotaxis GO:0030879 mammary gland development GO:0031589 cell-substrate adhesion GO:0032103 positive regulation of response to external stimulus GO:0032943 mononuclear cell proliferation GO:0032944 regulation of mononuclear cell proliferation GO:0032946 positive regulation of mononuclear cell proliferation GO:0033674 positive regulation of kinase activity GO:0035239 tube morphogenesis GO:0035264 multicellular organism growth GO:0036005 response to macrophage colony-stimulating factor GO:0036006 cellular response to macrophage colony-stimulating factor stimulus GO:0038145 macrophage colony-stimulating factor signaling pathway GO:0040014 regulation of multicellular organism growth GO:0040017 positive regulation of locomotion GO:0040018 positive regulation of multicellular organism growth GO:0042063 gliogenesis GO:0042117 monocyte activation GO:0042475 odontogenesis of dentin-containing tooth GO:0042476 odontogenesis GO:0042481 regulation of odontogenesis GO:0042482 positive regulation of odontogenesis GO:0042487 regulation of odontogenesis of dentin-containing tooth GO:0042488 positive regulation of odontogenesis of dentin-containing tooth GO:0045637 regulation of myeloid cell differentiation GO:0045639 positive regulation of myeloid cell differentiation GO:0045649 regulation of macrophage differentiation GO:0045651 positive regulation of macrophage differentiation GO:0045655 regulation of monocyte differentiation GO:0045657 positive regulation of monocyte differentiation GO:0045670 regulation of osteoclast differentiation GO:0045672 positive regulation of osteoclast differentiation GO:0045785 positive regulation of cell adhesion GO:0045860 positive regulation of protein kinase activity GO:0045927 positive regulation of growth GO:0046578 regulation of Ras protein signal transduction GO:0046579 positive regulation of Ras protein signal transduction GO:0048246 macrophage chemotaxis GO:0048638 regulation of developmental growth GO:0048639 positive regulation of developmental growth GO:0048732 gland development GO:0048754 branching morphogenesis of an epithelial tube GO:0048871 multicellular organismal homeostasis GO:0048872 homeostasis of number of cells GO:0048873 homeostasis of number of cells within a tissue GO:0050769 positive regulation of neurogenesis GO:0050900 leukocyte migration GO:0050920 regulation of chemotaxis GO:0050921 positive regulation of chemotaxis GO:0051056 regulation of small GTPase mediated signal transduction GO:0051057 positive regulation of small GTPase mediated signal transduction GO:0051272 positive regulation of cellular component movement GO:0051962 positive regulation of nervous system development GO:0060249 anatomical structure homeostasis GO:0060326 cell chemotaxis GO:0060443 mammary gland morphogenesis GO:0060444 branching involved in mammary gland duct morphogenesis GO:0060560 developmental growth involved in morphogenesis GO:0060562 epithelial tube morphogenesis GO:0060603 mammary gland duct morphogenesis GO:0060611 mammary gland fat development GO:0060612 adipose tissue development GO:0060759 regulation of response to cytokine stimulus GO:0060760 positive regulation of response to cytokine stimulus GO:0060763 mammary duct terminal end bud growth GO:0061138 morphogenesis of a branching epithelium GO:0061180 mammary gland epithelium development GO:0061448 connective tissue development GO:0070661 leukocyte proliferation GO:0070663 regulation of leukocyte proliferation GO:0070665 positive regulation of leukocyte proliferation GO:0071621 granulocyte chemotaxis GO:0071622 regulation of granulocyte chemotaxis GO:0071674 mononuclear cell migration GO:0071675 regulation of mononuclear cell migration GO:0090077 foam cell differentiation GO:0097529 myeloid leukocyte migration GO:0097530 granulocyte migration GO:1902105 regulation of leukocyte differentiation GO:1902107 positive regulation of leukocyte differentiation GO:1902226 regulation of macrophage colony-stimulating factor signaling pathway GO:1902228 positive regulation of macrophage colony-stimulating factor signaling pathway GO:1903131 mononuclear cell differentiation GO:1903706 regulation of hemopoiesis GO:1903708 positive regulation of hemopoiesis GO:1903969 regulation of response to macrophage colony-stimulating factor GO:1903971 positive regulation of response to macrophage colony-stimulating factor GO:1903972 regulation of cellular response to macrophage colony-stimulating factor stimulus GO:1903974 positive regulation of cellular response to macrophage colony-stimulating factor stimulus GO:1903975 regulation of glial cell migration GO:1903977 positive regulation of glial cell migration GO:1904124 microglial cell migration GO:1904139 regulation of microglial cell migration GO:1904141 positive regulation of microglial cell migration GO:2000027 regulation of organ morphogenesis GO:2000147 positive regulation of cell motility |
Molecular Function |
GO:0005125 cytokine activity GO:0005126 cytokine receptor binding GO:0005157 macrophage colony-stimulating factor receptor binding GO:0008083 growth factor activity |
Cellular Component |
GO:1990682 CSF1-CSF1R complex |
KEGG |
hsa04014 Ras signaling pathway hsa04015 Rap1 signaling pathway hsa04060 Cytokine-cytokine receptor interaction hsa04151 PI3K-Akt signaling pathway hsa04380 Osteoclast differentiation hsa04640 Hematopoietic cell lineage hsa04668 TNF signaling pathway |
Reactome |
R-HSA-1280215: Cytokine Signaling in Immune system R-HSA-168256: Immune System R-HSA-6783783: Interleukin-10 signaling R-HSA-449147: Signaling by Interleukins |
Summary | |
---|---|
Symbol | CSF1 |
Name | colony stimulating factor 1 (macrophage) |
Aliases | M-CSF; MCSF; MGC31930; CSF-1; lanimostim; Macrophage colony-stimulating factor 1 |
Chromosomal Location | 1p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between CSF1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between CSF1 and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | CSF1 |
Name | colony stimulating factor 1 (macrophage) |
Aliases | M-CSF; MCSF; MGC31930; CSF-1; lanimostim; Macrophage colony-stimulating factor 1 |
Chromosomal Location | 1p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of CSF1 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | CSF1 |
Name | colony stimulating factor 1 (macrophage) |
Aliases | M-CSF; MCSF; MGC31930; CSF-1; lanimostim; Macrophage colony-stimulating factor 1 |
Chromosomal Location | 1p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of CSF1 in various data sets.
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Points in the above scatter plot represent the mutation difference of CSF1 in various data sets.
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Summary | |
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Symbol | CSF1 |
Name | colony stimulating factor 1 (macrophage) |
Aliases | M-CSF; MCSF; MGC31930; CSF-1; lanimostim; Macrophage colony-stimulating factor 1 |
Chromosomal Location | 1p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of CSF1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | CSF1 |
Name | colony stimulating factor 1 (macrophage) |
Aliases | M-CSF; MCSF; MGC31930; CSF-1; lanimostim; Macrophage colony-stimulating factor 1 |
Chromosomal Location | 1p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of CSF1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by CSF1. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | CSF1 |
Name | colony stimulating factor 1 (macrophage) |
Aliases | M-CSF; MCSF; MGC31930; CSF-1; lanimostim; Macrophage colony-stimulating factor 1 |
Chromosomal Location | 1p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of CSF1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | CSF1 |
Name | colony stimulating factor 1 (macrophage) |
Aliases | M-CSF; MCSF; MGC31930; CSF-1; lanimostim; Macrophage colony-stimulating factor 1 |
Chromosomal Location | 1p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of CSF1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | CSF1 |
Name | colony stimulating factor 1 (macrophage) |
Aliases | M-CSF; MCSF; MGC31930; CSF-1; lanimostim; Macrophage colony-stimulating factor 1 |
Chromosomal Location | 1p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between CSF1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | CSF1 |
Name | colony stimulating factor 1 (macrophage) |
Aliases | M-CSF; MCSF; MGC31930; CSF-1; lanimostim; Macrophage colony-stimulating factor 1 |
Chromosomal Location | 1p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting CSF1 collected from DrugBank database. |
There is no record. |