Summary | |
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Symbol | CSF1R |
Name | colony stimulating factor 1 receptor |
Aliases | C-FMS; CSFR; CD115; FMS; McDonough feline sarcoma viral (v-fms) oncogene homolog; CSF-1R; FIM2; HDLS; M-CSF- ...... |
Chromosomal Location | 5q32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cell membrane; Single-pass type I membrane protein. |
Domain |
PF00047 Immunoglobulin domain PF07714 Protein tyrosine kinase |
Function |
Tyrosine-protein kinase that acts as cell-surface receptor for CSF1 and IL34 and plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines in response to IL34 and CSF1, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone and tooth development. Required for normal male and female fertility, and for normal development of milk ducts and acinar structures in the mammary gland during pregnancy. Promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration, and promotes cancer cell invasion. Activates several signaling pathways in response to ligand binding. Phosphorylates PIK3R1, PLCG2, GRB2, SLA2 and CBL. Activation of PLCG2 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate, that then lead to the activation of protein kinase C family members, especially PRKCD. Phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, leads to activation of the AKT1 signaling pathway. Activated CSF1R also mediates activation of the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1, and of the SRC family kinases SRC, FYN and YES1. Activated CSF1R transmits signals both via proteins that directly interact with phosphorylated tyrosine residues in its intracellular domain, or via adapter proteins, such as GRB2. Promotes activation of STAT family members STAT3, STAT5A and/or STAT5B. Promotes tyrosine phosphorylation of SHC1 and INPP5D/SHIP-1. Receptor signaling is down-regulated by protein phosphatases, such as INPP5D/SHIP-1, that dephosphorylate the receptor and its downstream effectors, and by rapid internalization of the activated receptor. |
Biological Process |
GO:0001819 positive regulation of cytokine production GO:0001894 tissue homeostasis GO:0002521 leukocyte differentiation GO:0002573 myeloid leukocyte differentiation GO:0006644 phospholipid metabolic process GO:0006650 glycerophospholipid metabolic process GO:0007259 JAK-STAT cascade GO:0007260 tyrosine phosphorylation of STAT protein GO:0007409 axonogenesis GO:0007411 axon guidance GO:0008360 regulation of cell shape GO:0009306 protein secretion GO:0018108 peptidyl-tyrosine phosphorylation GO:0018212 peptidyl-tyrosine modification GO:0021537 telencephalon development GO:0021772 olfactory bulb development GO:0021872 forebrain generation of neurons GO:0021879 forebrain neuron differentiation GO:0021953 central nervous system neuron differentiation GO:0021988 olfactory lobe development GO:0022604 regulation of cell morphogenesis GO:0022612 gland morphogenesis GO:0030099 myeloid cell differentiation GO:0030224 monocyte differentiation GO:0030225 macrophage differentiation GO:0030316 osteoclast differentiation GO:0030335 positive regulation of cell migration GO:0030879 mammary gland development GO:0030900 forebrain development GO:0031529 ruffle organization GO:0031532 actin cytoskeleton reorganization GO:0032602 chemokine production GO:0032642 regulation of chemokine production GO:0032722 positive regulation of chemokine production GO:0032844 regulation of homeostatic process GO:0032956 regulation of actin cytoskeleton organization GO:0032970 regulation of actin filament-based process GO:0033674 positive regulation of kinase activity GO:0034103 regulation of tissue remodeling GO:0034330 cell junction organization GO:0034331 cell junction maintenance GO:0035239 tube morphogenesis GO:0036005 response to macrophage colony-stimulating factor GO:0036006 cellular response to macrophage colony-stimulating factor stimulus GO:0038145 macrophage colony-stimulating factor signaling pathway GO:0040017 positive regulation of locomotion GO:0042503 tyrosine phosphorylation of Stat3 protein GO:0042509 regulation of tyrosine phosphorylation of STAT protein GO:0042516 regulation of tyrosine phosphorylation of Stat3 protein GO:0042517 positive regulation of tyrosine phosphorylation of Stat3 protein GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein GO:0043410 positive regulation of MAPK cascade GO:0043954 cellular component maintenance GO:0045124 regulation of bone resorption GO:0045216 cell-cell junction organization GO:0045217 cell-cell junction maintenance GO:0045453 bone resorption GO:0045860 positive regulation of protein kinase activity GO:0046425 regulation of JAK-STAT cascade GO:0046427 positive regulation of JAK-STAT cascade GO:0046486 glycerolipid metabolic process GO:0046488 phosphatidylinositol metabolic process GO:0046777 protein autophosphorylation GO:0046849 bone remodeling GO:0046850 regulation of bone remodeling GO:0048015 phosphatidylinositol-mediated signaling GO:0048017 inositol lipid-mediated signaling GO:0048667 cell morphogenesis involved in neuron differentiation GO:0048732 gland development GO:0048771 tissue remodeling GO:0048871 multicellular organismal homeostasis GO:0050663 cytokine secretion GO:0050707 regulation of cytokine secretion GO:0050708 regulation of protein secretion GO:0050714 positive regulation of protein secretion GO:0050715 positive regulation of cytokine secretion GO:0050730 regulation of peptidyl-tyrosine phosphorylation GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation GO:0051047 positive regulation of secretion GO:0051222 positive regulation of protein transport GO:0051272 positive regulation of cellular component movement GO:0051493 regulation of cytoskeleton organization GO:0060249 anatomical structure homeostasis GO:0060443 mammary gland morphogenesis GO:0060562 epithelial tube morphogenesis GO:0060603 mammary gland duct morphogenesis GO:0061097 regulation of protein tyrosine kinase activity GO:0061098 positive regulation of protein tyrosine kinase activity GO:0061180 mammary gland epithelium development GO:0061564 axon development GO:0070371 ERK1 and ERK2 cascade GO:0070372 regulation of ERK1 and ERK2 cascade GO:0070374 positive regulation of ERK1 and ERK2 cascade GO:0071900 regulation of protein serine/threonine kinase activity GO:0071902 positive regulation of protein serine/threonine kinase activity GO:0090195 chemokine secretion GO:0090196 regulation of chemokine secretion GO:0090197 positive regulation of chemokine secretion GO:0097485 neuron projection guidance GO:0097696 STAT cascade GO:1903131 mononuclear cell differentiation GO:1903532 positive regulation of secretion by cell GO:1904892 regulation of STAT cascade GO:1904894 positive regulation of STAT cascade GO:1904951 positive regulation of establishment of protein localization GO:2000147 positive regulation of cell motility GO:2000249 regulation of actin cytoskeleton reorganization |
Molecular Function |
GO:0004713 protein tyrosine kinase activity GO:0004714 transmembrane receptor protein tyrosine kinase activity GO:0005011 macrophage colony-stimulating factor receptor activity GO:0019199 transmembrane receptor protein kinase activity GO:0019902 phosphatase binding GO:0019903 protein phosphatase binding GO:0019955 cytokine binding |
Cellular Component |
GO:1990682 CSF1-CSF1R complex |
KEGG |
hsa04014 Ras signaling pathway hsa04015 Rap1 signaling pathway hsa04060 Cytokine-cytokine receptor interaction hsa04144 Endocytosis hsa04151 PI3K-Akt signaling pathway hsa04380 Osteoclast differentiation hsa04640 Hematopoietic cell lineage |
Reactome |
R-HSA-1280215: Cytokine Signaling in Immune system R-HSA-168256: Immune System R-HSA-449147: Signaling by Interleukins |
Summary | |
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Symbol | CSF1R |
Name | colony stimulating factor 1 receptor |
Aliases | C-FMS; CSFR; CD115; FMS; McDonough feline sarcoma viral (v-fms) oncogene homolog; CSF-1R; FIM2; HDLS; M-CSF- ...... |
Chromosomal Location | 5q32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between CSF1R and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between CSF1R and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | CSF1R |
Name | colony stimulating factor 1 receptor |
Aliases | C-FMS; CSFR; CD115; FMS; McDonough feline sarcoma viral (v-fms) oncogene homolog; CSF-1R; FIM2; HDLS; M-CSF- ...... |
Chromosomal Location | 5q32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of CSF1R in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | CSF1R |
Name | colony stimulating factor 1 receptor |
Aliases | C-FMS; CSFR; CD115; FMS; McDonough feline sarcoma viral (v-fms) oncogene homolog; CSF-1R; FIM2; HDLS; M-CSF- ...... |
Chromosomal Location | 5q32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of CSF1R in various data sets.
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Points in the above scatter plot represent the mutation difference of CSF1R in various data sets.
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Summary | |
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Symbol | CSF1R |
Name | colony stimulating factor 1 receptor |
Aliases | C-FMS; CSFR; CD115; FMS; McDonough feline sarcoma viral (v-fms) oncogene homolog; CSF-1R; FIM2; HDLS; M-CSF- ...... |
Chromosomal Location | 5q32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of CSF1R. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | CSF1R |
Name | colony stimulating factor 1 receptor |
Aliases | C-FMS; CSFR; CD115; FMS; McDonough feline sarcoma viral (v-fms) oncogene homolog; CSF-1R; FIM2; HDLS; M-CSF- ...... |
Chromosomal Location | 5q32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of CSF1R. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by CSF1R. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | CSF1R |
Name | colony stimulating factor 1 receptor |
Aliases | C-FMS; CSFR; CD115; FMS; McDonough feline sarcoma viral (v-fms) oncogene homolog; CSF-1R; FIM2; HDLS; M-CSF- ...... |
Chromosomal Location | 5q32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of CSF1R. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | CSF1R |
Name | colony stimulating factor 1 receptor |
Aliases | C-FMS; CSFR; CD115; FMS; McDonough feline sarcoma viral (v-fms) oncogene homolog; CSF-1R; FIM2; HDLS; M-CSF- ...... |
Chromosomal Location | 5q32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of CSF1R expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | CSF1R |
Name | colony stimulating factor 1 receptor |
Aliases | C-FMS; CSFR; CD115; FMS; McDonough feline sarcoma viral (v-fms) oncogene homolog; CSF-1R; FIM2; HDLS; M-CSF- ...... |
Chromosomal Location | 5q32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between CSF1R and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | CSF1R |
Name | colony stimulating factor 1 receptor |
Aliases | C-FMS; CSFR; CD115; FMS; McDonough feline sarcoma viral (v-fms) oncogene homolog; CSF-1R; FIM2; HDLS; M-CSF- ...... |
Chromosomal Location | 5q32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting CSF1R collected from DrugBank database. |
Details on drugs targeting CSF1R.
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