Summary | |
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Symbol | CSF2 |
Name | colony stimulating factor 2 (granulocyte-macrophage) |
Aliases | GM-CSF; GMCSF; sargramostim; molgramostin; granulocyte-macrophage colony stimulating factor; granulocyte mac ...... |
Chromosomal Location | 5q23-q31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Secreted |
Domain |
PF01109 Granulocyte-macrophage colony-stimulating factor |
Function |
Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes. |
Biological Process |
GO:0001701 in utero embryonic development GO:0001773 myeloid dendritic cell activation GO:0001819 positive regulation of cytokine production GO:0001821 histamine secretion GO:0001890 placenta development GO:0001892 embryonic placenta development GO:0002237 response to molecule of bacterial origin GO:0002274 myeloid leukocyte activation GO:0002521 leukocyte differentiation GO:0002573 myeloid leukocyte differentiation GO:0006260 DNA replication GO:0006275 regulation of DNA replication GO:0007259 JAK-STAT cascade GO:0007260 tyrosine phosphorylation of STAT protein GO:0007622 rhythmic behavior GO:0007623 circadian rhythm GO:0010035 response to inorganic substance GO:0010742 macrophage derived foam cell differentiation GO:0010743 regulation of macrophage derived foam cell differentiation GO:0010744 positive regulation of macrophage derived foam cell differentiation GO:0018108 peptidyl-tyrosine phosphorylation GO:0018212 peptidyl-tyrosine modification GO:0019835 cytolysis GO:0022410 circadian sleep/wake cycle process GO:0030099 myeloid cell differentiation GO:0030223 neutrophil differentiation GO:0030224 monocyte differentiation GO:0030431 sleep GO:0030851 granulocyte differentiation GO:0031334 positive regulation of protein complex assembly GO:0032496 response to lipopolysaccharide GO:0032627 interleukin-23 production GO:0032667 regulation of interleukin-23 production GO:0032747 positive regulation of interleukin-23 production GO:0034021 response to silicon dioxide GO:0034405 response to fluid shear stress GO:0038034 signal transduction in absence of ligand GO:0042044 fluid transport GO:0042045 epithelial fluid transport GO:0042116 macrophage activation GO:0042268 regulation of cytolysis GO:0042506 tyrosine phosphorylation of Stat5 protein GO:0042509 regulation of tyrosine phosphorylation of STAT protein GO:0042522 regulation of tyrosine phosphorylation of Stat5 protein GO:0042523 positive regulation of tyrosine phosphorylation of Stat5 protein GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein GO:0042745 circadian sleep/wake cycle GO:0042749 regulation of circadian sleep/wake cycle GO:0042752 regulation of circadian rhythm GO:0043011 myeloid dendritic cell differentiation GO:0043254 regulation of protein complex assembly GO:0044089 positive regulation of cellular component biogenesis GO:0044708 single-organism behavior GO:0045117 azole transport GO:0045187 regulation of circadian sleep/wake cycle, sleep GO:0045740 positive regulation of DNA replication GO:0045918 negative regulation of cytolysis GO:0046425 regulation of JAK-STAT cascade GO:0046427 positive regulation of JAK-STAT cascade GO:0048511 rhythmic process GO:0048512 circadian behavior GO:0048568 embryonic organ development GO:0048608 reproductive structure development GO:0050730 regulation of peptidyl-tyrosine phosphorylation GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation GO:0050795 regulation of behavior GO:0050802 circadian sleep/wake cycle, sleep GO:0051052 regulation of DNA metabolic process GO:0051054 positive regulation of DNA metabolic process GO:0051608 histamine transport GO:0061458 reproductive system development GO:0070633 transepithelial transport GO:0071216 cellular response to biotic stimulus GO:0071219 cellular response to molecule of bacterial origin GO:0071222 cellular response to lipopolysaccharide GO:0071396 cellular response to lipid GO:0071800 podosome assembly GO:0071801 regulation of podosome assembly GO:0071803 positive regulation of podosome assembly GO:0090077 foam cell differentiation GO:0097028 dendritic cell differentiation GO:0097191 extrinsic apoptotic signaling pathway GO:0097192 extrinsic apoptotic signaling pathway in absence of ligand GO:0097696 STAT cascade GO:1901099 negative regulation of signal transduction in absence of ligand GO:1902115 regulation of organelle assembly GO:1902117 positive regulation of organelle assembly GO:1903131 mononuclear cell differentiation GO:1904892 regulation of STAT cascade GO:1904894 positive regulation of STAT cascade GO:2001233 regulation of apoptotic signaling pathway GO:2001234 negative regulation of apoptotic signaling pathway GO:2001236 regulation of extrinsic apoptotic signaling pathway GO:2001237 negative regulation of extrinsic apoptotic signaling pathway GO:2001239 regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand |
Molecular Function |
GO:0004713 protein tyrosine kinase activity GO:0005085 guanyl-nucleotide exchange factor activity GO:0005088 Ras guanyl-nucleotide exchange factor activity GO:0005125 cytokine activity GO:0005126 cytokine receptor binding GO:0005129 granulocyte macrophage colony-stimulating factor receptor binding GO:0008083 growth factor activity GO:0070851 growth factor receptor binding |
Cellular Component | - |
KEGG |
hsa04060 Cytokine-cytokine receptor interaction hsa04630 Jak-STAT signaling pathway hsa04640 Hematopoietic cell lineage hsa04650 Natural killer cell mediated cytotoxicity hsa04660 T cell receptor signaling pathway hsa04664 Fc epsilon RI signaling pathway hsa04668 TNF signaling pathway |
Reactome |
R-HSA-170984: ARMS-mediated activation R-HSA-422475: Axon guidance R-HSA-1280215: Cytokine Signaling in Immune system R-HSA-2172127: DAP12 interactions R-HSA-2424491: DAP12 signaling R-HSA-1266738: Developmental Biology R-HSA-186763: Downstream signal transduction R-HSA-2871796: FCERI mediated MAPK activation R-HSA-2454202: Fc epsilon receptor (FCERI) signaling R-HSA-170968: Frs2-mediated activation R-HSA-392451: G beta R-HSA-397795: G-protein beta R-HSA-388396: GPCR downstream signaling R-HSA-114604: GPVI-mediated activation cascade R-HSA-179812: GRB2 events in EGFR signaling R-HSA-881907: Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-109582: Hemostasis R-HSA-2428924: IGF1R signaling cascade R-HSA-112399: IRS-mediated signalling R-HSA-2428928: IRS-related events triggered by IGF1R R-HSA-168256: Immune System R-HSA-168249: Innate Immune System R-HSA-74751: Insulin receptor signalling cascade R-HSA-912526: Interleukin receptor SHC signaling R-HSA-6783783: Interleukin-10 signaling R-HSA-451927: Interleukin-2 signaling R-HSA-512988: Interleukin-3, 5 and GM-CSF signaling R-HSA-5683057: MAPK family signaling cascades R-HSA-5684996: MAPK1/MAPK3 signaling R-HSA-375165: NCAM signaling for neurite out-growth R-HSA-187037: NGF signalling via TRKA from the plasma membrane R-HSA-76002: Platelet activation, signaling and aggregation R-HSA-169893: Prolonged ERK activation events R-HSA-5673001: RAF/MAP kinase cascade R-HSA-8853659: RET signaling R-HSA-180336: SHC1 events in EGFR signaling R-HSA-112412: SOS-mediated signalling R-HSA-162582: Signal Transduction R-HSA-177929: Signaling by EGFR R-HSA-372790: Signaling by GPCR R-HSA-74752: Signaling by Insulin receptor R-HSA-449147: Signaling by Interleukins R-HSA-2586552: Signaling by Leptin R-HSA-186797: Signaling by PDGF R-HSA-1433557: Signaling by SCF-KIT R-HSA-2404192: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-194138: Signaling by VEGF R-HSA-166520: Signalling by NGF R-HSA-187687: Signalling to ERKs R-HSA-167044: Signalling to RAS R-HSA-187706: Signalling to p38 via RIT and RIN R-HSA-4420097: VEGFA-VEGFR2 Pathway R-HSA-5218921: VEGFR2 mediated cell proliferation |
Summary | |
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Symbol | CSF2 |
Name | colony stimulating factor 2 (granulocyte-macrophage) |
Aliases | GM-CSF; GMCSF; sargramostim; molgramostin; granulocyte-macrophage colony stimulating factor; granulocyte mac ...... |
Chromosomal Location | 5q23-q31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between CSF2 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between CSF2 and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | CSF2 |
Name | colony stimulating factor 2 (granulocyte-macrophage) |
Aliases | GM-CSF; GMCSF; sargramostim; molgramostin; granulocyte-macrophage colony stimulating factor; granulocyte mac ...... |
Chromosomal Location | 5q23-q31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of CSF2 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | CSF2 |
Name | colony stimulating factor 2 (granulocyte-macrophage) |
Aliases | GM-CSF; GMCSF; sargramostim; molgramostin; granulocyte-macrophage colony stimulating factor; granulocyte mac ...... |
Chromosomal Location | 5q23-q31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of CSF2 in various data sets.
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Points in the above scatter plot represent the mutation difference of CSF2 in various data sets.
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Summary | |
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Symbol | CSF2 |
Name | colony stimulating factor 2 (granulocyte-macrophage) |
Aliases | GM-CSF; GMCSF; sargramostim; molgramostin; granulocyte-macrophage colony stimulating factor; granulocyte mac ...... |
Chromosomal Location | 5q23-q31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of CSF2. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | CSF2 |
Name | colony stimulating factor 2 (granulocyte-macrophage) |
Aliases | GM-CSF; GMCSF; sargramostim; molgramostin; granulocyte-macrophage colony stimulating factor; granulocyte mac ...... |
Chromosomal Location | 5q23-q31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of CSF2. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by CSF2. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | CSF2 |
Name | colony stimulating factor 2 (granulocyte-macrophage) |
Aliases | GM-CSF; GMCSF; sargramostim; molgramostin; granulocyte-macrophage colony stimulating factor; granulocyte mac ...... |
Chromosomal Location | 5q23-q31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of CSF2. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | CSF2 |
Name | colony stimulating factor 2 (granulocyte-macrophage) |
Aliases | GM-CSF; GMCSF; sargramostim; molgramostin; granulocyte-macrophage colony stimulating factor; granulocyte mac ...... |
Chromosomal Location | 5q23-q31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of CSF2 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | CSF2 |
Name | colony stimulating factor 2 (granulocyte-macrophage) |
Aliases | GM-CSF; GMCSF; sargramostim; molgramostin; granulocyte-macrophage colony stimulating factor; granulocyte mac ...... |
Chromosomal Location | 5q23-q31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between CSF2 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | CSF2 |
Name | colony stimulating factor 2 (granulocyte-macrophage) |
Aliases | GM-CSF; GMCSF; sargramostim; molgramostin; granulocyte-macrophage colony stimulating factor; granulocyte mac ...... |
Chromosomal Location | 5q23-q31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting CSF2 collected from DrugBank database. |
Details on drugs targeting CSF2.
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