Summary | |
---|---|
Symbol | CSTL1 |
Name | cystatin-like 1 |
Aliases | dJ322G13.4; CTES1; RCET11 |
Chromosomal Location | 20p11.21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Secreted |
Domain |
PF00031 Cystatin domain |
Function |
- |
Biological Process |
GO:0010466 negative regulation of peptidase activity GO:0010951 negative regulation of endopeptidase activity GO:0045861 negative regulation of proteolysis GO:0051346 negative regulation of hydrolase activity GO:0052547 regulation of peptidase activity GO:0052548 regulation of endopeptidase activity GO:2000116 regulation of cysteine-type endopeptidase activity GO:2000117 negative regulation of cysteine-type endopeptidase activity |
Molecular Function |
GO:0002020 protease binding GO:0004857 enzyme inhibitor activity GO:0004866 endopeptidase inhibitor activity GO:0004869 cysteine-type endopeptidase inhibitor activity GO:0030414 peptidase inhibitor activity GO:0061134 peptidase regulator activity GO:0061135 endopeptidase regulator activity |
Cellular Component | - |
KEGG | - |
Reactome | - |
Summary | |
---|---|
Symbol | CSTL1 |
Name | cystatin-like 1 |
Aliases | dJ322G13.4; CTES1; RCET11 |
Chromosomal Location | 20p11.21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between CSTL1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | CSTL1 |
Name | cystatin-like 1 |
Aliases | dJ322G13.4; CTES1; RCET11 |
Chromosomal Location | 20p11.21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of CSTL1 in screening data sets for detecting immune reponses.
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Summary | |
---|---|
Symbol | CSTL1 |
Name | cystatin-like 1 |
Aliases | dJ322G13.4; CTES1; RCET11 |
Chromosomal Location | 20p11.21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of CSTL1 in various data sets.
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Points in the above scatter plot represent the mutation difference of CSTL1 in various data sets.
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Summary | |
---|---|
Symbol | CSTL1 |
Name | cystatin-like 1 |
Aliases | dJ322G13.4; CTES1; RCET11 |
Chromosomal Location | 20p11.21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of CSTL1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | CSTL1 |
Name | cystatin-like 1 |
Aliases | dJ322G13.4; CTES1; RCET11 |
Chromosomal Location | 20p11.21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of CSTL1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by CSTL1. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | CSTL1 |
Name | cystatin-like 1 |
Aliases | dJ322G13.4; CTES1; RCET11 |
Chromosomal Location | 20p11.21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of CSTL1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | CSTL1 |
Name | cystatin-like 1 |
Aliases | dJ322G13.4; CTES1; RCET11 |
Chromosomal Location | 20p11.21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of CSTL1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | CSTL1 |
Name | cystatin-like 1 |
Aliases | dJ322G13.4; CTES1; RCET11 |
Chromosomal Location | 20p11.21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between CSTL1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |