Summary | |
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Symbol | CTHRC1 |
Name | collagen triple helix repeat containing 1 |
Aliases | Protein NMTC1; Collagen triple helix repeat-containing protein 1 |
Chromosomal Location | 8q22.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Secreted, extracellular space, extracellular matrix |
Domain | - |
Function |
May act as a negative regulator of collagen matrix deposition. |
Biological Process |
GO:0001503 ossification GO:0001649 osteoblast differentiation GO:0001736 establishment of planar polarity GO:0001738 morphogenesis of a polarized epithelium GO:0001838 embryonic epithelial tube formation GO:0001841 neural tube formation GO:0001843 neural tube closure GO:0007164 establishment of tissue polarity GO:0007423 sensory organ development GO:0014020 primary neural tube formation GO:0016055 Wnt signaling pathway GO:0016331 morphogenesis of embryonic epithelium GO:0021915 neural tube development GO:0030111 regulation of Wnt signaling pathway GO:0030178 negative regulation of Wnt signaling pathway GO:0030278 regulation of ossification GO:0032092 positive regulation of protein binding GO:0033687 osteoblast proliferation GO:0033688 regulation of osteoblast proliferation GO:0033690 positive regulation of osteoblast proliferation GO:0035148 tube formation GO:0035239 tube morphogenesis GO:0035567 non-canonical Wnt signaling pathway GO:0042249 establishment of planar polarity of embryonic epithelium GO:0042471 ear morphogenesis GO:0042472 inner ear morphogenesis GO:0042490 mechanoreceptor differentiation GO:0043393 regulation of protein binding GO:0043583 ear development GO:0043932 ossification involved in bone remodeling GO:0045667 regulation of osteoblast differentiation GO:0045669 positive regulation of osteoblast differentiation GO:0045778 positive regulation of ossification GO:0046849 bone remodeling GO:0048562 embryonic organ morphogenesis GO:0048568 embryonic organ development GO:0048771 tissue remodeling GO:0048839 inner ear development GO:0051098 regulation of binding GO:0051099 positive regulation of binding GO:0060070 canonical Wnt signaling pathway GO:0060071 Wnt signaling pathway, planar cell polarity pathway GO:0060113 inner ear receptor cell differentiation GO:0060119 inner ear receptor cell development GO:0060122 inner ear receptor stereocilium organization GO:0060562 epithelial tube morphogenesis GO:0060606 tube closure GO:0060828 regulation of canonical Wnt signaling pathway GO:0072175 epithelial tube formation GO:0090090 negative regulation of canonical Wnt signaling pathway GO:0090102 cochlea development GO:0090103 cochlea morphogenesis GO:0090175 regulation of establishment of planar polarity GO:0090177 establishment of planar polarity involved in neural tube closure GO:0090596 sensory organ morphogenesis GO:0198738 cell-cell signaling by wnt GO:1905330 regulation of morphogenesis of an epithelium GO:2000027 regulation of organ morphogenesis |
Molecular Function |
GO:0001664 G-protein coupled receptor binding GO:0005109 frizzled binding GO:0017147 Wnt-protein binding |
Cellular Component |
GO:0005578 proteinaceous extracellular matrix GO:0005581 collagen trimer |
KEGG | - |
Reactome | - |
Summary | |
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Symbol | CTHRC1 |
Name | collagen triple helix repeat containing 1 |
Aliases | Protein NMTC1; Collagen triple helix repeat-containing protein 1 |
Chromosomal Location | 8q22.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between CTHRC1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | CTHRC1 |
Name | collagen triple helix repeat containing 1 |
Aliases | Protein NMTC1; Collagen triple helix repeat-containing protein 1 |
Chromosomal Location | 8q22.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of CTHRC1 in screening data sets for detecting immune reponses.
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Summary | |
---|---|
Symbol | CTHRC1 |
Name | collagen triple helix repeat containing 1 |
Aliases | Protein NMTC1; Collagen triple helix repeat-containing protein 1 |
Chromosomal Location | 8q22.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of CTHRC1 in various data sets.
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Points in the above scatter plot represent the mutation difference of CTHRC1 in various data sets.
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Summary | |
---|---|
Symbol | CTHRC1 |
Name | collagen triple helix repeat containing 1 |
Aliases | Protein NMTC1; Collagen triple helix repeat-containing protein 1 |
Chromosomal Location | 8q22.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of CTHRC1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | CTHRC1 |
Name | collagen triple helix repeat containing 1 |
Aliases | Protein NMTC1; Collagen triple helix repeat-containing protein 1 |
Chromosomal Location | 8q22.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of CTHRC1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by CTHRC1. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | CTHRC1 |
Name | collagen triple helix repeat containing 1 |
Aliases | Protein NMTC1; Collagen triple helix repeat-containing protein 1 |
Chromosomal Location | 8q22.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of CTHRC1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | CTHRC1 |
Name | collagen triple helix repeat containing 1 |
Aliases | Protein NMTC1; Collagen triple helix repeat-containing protein 1 |
Chromosomal Location | 8q22.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of CTHRC1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | CTHRC1 |
Name | collagen triple helix repeat containing 1 |
Aliases | Protein NMTC1; Collagen triple helix repeat-containing protein 1 |
Chromosomal Location | 8q22.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between CTHRC1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | CTHRC1 |
Name | collagen triple helix repeat containing 1 |
Aliases | Protein NMTC1; Collagen triple helix repeat-containing protein 1 |
Chromosomal Location | 8q22.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting CTHRC1 collected from DrugBank database. |
There is no record. |