Browse CTPS1

Summary
SymbolCTPS1
NameCTP synthase 1
Aliases CTPS; CTP synthase; IMD24; CTP synthetase 1; UTP--ammonia ligase 1; cytidine 5'-triphosphate synthetase; cyt ......
Chromosomal Location1p34.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location -
Domain PF06418 CTP synthase N-terminus
PF00117 Glutamine amidotransferase class-I
Function

This enzyme is involved in the de novo synthesis of CTP, a precursor of DNA, RNA and phospholipids. Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as a source of nitrogen. This enzyme and its product, CTP, play a crucial role in the proliferation of activated lymphocytes and therefore in immunity.

> Gene Ontology
 
Biological Process GO:0006213 pyrimidine nucleoside metabolic process
GO:0006220 pyrimidine nucleotide metabolic process
GO:0006221 pyrimidine nucleotide biosynthetic process
GO:0006241 CTP biosynthetic process
GO:0006520 cellular amino acid metabolic process
GO:0006541 glutamine metabolic process
GO:0007159 leukocyte cell-cell adhesion
GO:0009064 glutamine family amino acid metabolic process
GO:0009116 nucleoside metabolic process
GO:0009119 ribonucleoside metabolic process
GO:0009141 nucleoside triphosphate metabolic process
GO:0009142 nucleoside triphosphate biosynthetic process
GO:0009147 pyrimidine nucleoside triphosphate metabolic process
GO:0009148 pyrimidine nucleoside triphosphate biosynthetic process
GO:0009163 nucleoside biosynthetic process
GO:0009165 nucleotide biosynthetic process
GO:0009199 ribonucleoside triphosphate metabolic process
GO:0009201 ribonucleoside triphosphate biosynthetic process
GO:0009208 pyrimidine ribonucleoside triphosphate metabolic process
GO:0009209 pyrimidine ribonucleoside triphosphate biosynthetic process
GO:0009218 pyrimidine ribonucleotide metabolic process
GO:0009220 pyrimidine ribonucleotide biosynthetic process
GO:0009260 ribonucleotide biosynthetic process
GO:0015949 nucleobase-containing small molecule interconversion
GO:0032943 mononuclear cell proliferation
GO:0042098 T cell proliferation
GO:0042100 B cell proliferation
GO:0042110 T cell activation
GO:0042113 B cell activation
GO:0042455 ribonucleoside biosynthetic process
GO:0042493 response to drug
GO:0044210 'de novo' CTP biosynthetic process
GO:0046036 CTP metabolic process
GO:0046131 pyrimidine ribonucleoside metabolic process
GO:0046132 pyrimidine ribonucleoside biosynthetic process
GO:0046134 pyrimidine nucleoside biosynthetic process
GO:0046390 ribose phosphate biosynthetic process
GO:0046651 lymphocyte proliferation
GO:0070486 leukocyte aggregation
GO:0070489 T cell aggregation
GO:0070661 leukocyte proliferation
GO:0071593 lymphocyte aggregation
GO:0072527 pyrimidine-containing compound metabolic process
GO:0072528 pyrimidine-containing compound biosynthetic process
GO:1901293 nucleoside phosphate biosynthetic process
GO:1901605 alpha-amino acid metabolic process
GO:1901657 glycosyl compound metabolic process
GO:1901659 glycosyl compound biosynthetic process
Molecular Function GO:0003883 CTP synthase activity
GO:0016874 ligase activity
GO:0016879 ligase activity, forming carbon-nitrogen bonds
Cellular Component -
> KEGG and Reactome Pathway
 
KEGG hsa00240 Pyrimidine metabolism
hsa01100 Metabolic pathways
Reactome R-HSA-1430728: Metabolism
R-HSA-15869: Metabolism of nucleotides
R-HSA-499943: Synthesis and interconversion of nucleotide di- and triphosphates
Summary
SymbolCTPS1
NameCTP synthase 1
Aliases CTPS; CTP synthase; IMD24; CTP synthetase 1; UTP--ammonia ligase 1; cytidine 5'-triphosphate synthetase; cyt ......
Chromosomal Location1p34.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between CTPS1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.

Summary
SymbolCTPS1
NameCTP synthase 1
Aliases CTPS; CTP synthase; IMD24; CTP synthetase 1; UTP--ammonia ligase 1; cytidine 5'-triphosphate synthetase; cyt ......
Chromosomal Location1p34.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of CTPS1 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NS NA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell logFC: -1.69; FDR: 0.04110 Resistant to T cell-mediated killing
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NS NA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NS NA/NS
24476824shRNAmelanomaB16Primary screen NA/NS NA/NS
24476824shRNAmelanomaB16Secondary screen NA/NS NA/NS
Summary
SymbolCTPS1
NameCTP synthase 1
Aliases CTPS; CTP synthase; IMD24; CTP synthetase 1; UTP--ammonia ligase 1; cytidine 5'-triphosphate synthetase; cyt ......
Chromosomal Location1p34.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of CTPS1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.3040.191
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-0.1550.935
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.4110.765
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.1380.646
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.2570.896
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.0170.995
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.0630.875
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-0.3930.802
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.6170.712
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 48-0.5720.619
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.2330.881
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.330.00119
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of CTPS1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27733.71.42.30.469
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27593.71.720.532
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21170001
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91611.16.24.91
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 592011.18.91
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38270001
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22130001
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 111307.7-7.71
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 51208.3-8.31
Summary
SymbolCTPS1
NameCTP synthase 1
Aliases CTPS; CTP synthase; IMD24; CTP synthetase 1; UTP--ammonia ligase 1; cytidine 5'-triphosphate synthetase; cyt ......
Chromosomal Location1p34.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of CTPS1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolCTPS1
NameCTP synthase 1
Aliases CTPS; CTP synthase; IMD24; CTP synthetase 1; UTP--ammonia ligase 1; cytidine 5'-triphosphate synthetase; cyt ......
Chromosomal Location1p34.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of CTPS1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by CTPS1.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolCTPS1
NameCTP synthase 1
Aliases CTPS; CTP synthase; IMD24; CTP synthetase 1; UTP--ammonia ligase 1; cytidine 5'-triphosphate synthetase; cyt ......
Chromosomal Location1p34.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of CTPS1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolCTPS1
NameCTP synthase 1
Aliases CTPS; CTP synthase; IMD24; CTP synthetase 1; UTP--ammonia ligase 1; cytidine 5'-triphosphate synthetase; cyt ......
Chromosomal Location1p34.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of CTPS1 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolCTPS1
NameCTP synthase 1
Aliases CTPS; CTP synthase; IMD24; CTP synthetase 1; UTP--ammonia ligase 1; cytidine 5'-triphosphate synthetase; cyt ......
Chromosomal Location1p34.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between CTPS1 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolCTPS1
NameCTP synthase 1
Aliases CTPS; CTP synthase; IMD24; CTP synthetase 1; UTP--ammonia ligase 1; cytidine 5'-triphosphate synthetase; cyt ......
Chromosomal Location1p34.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting CTPS1 collected from DrugBank database.
> Drugs from DrugBank database
 

  Details on drugs targeting CTPS1.
ID Name Drug Type Targets #Targets
DB00130L-GlutamineSmall MoleculeCTPS1, GLUL, PPAT3