Summary | |
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Symbol | CTPS1 |
Name | CTP synthase 1 |
Aliases | CTPS; CTP synthase; IMD24; CTP synthetase 1; UTP--ammonia ligase 1; cytidine 5'-triphosphate synthetase; cyt ...... |
Chromosomal Location | 1p34.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | - |
Domain |
PF06418 CTP synthase N-terminus PF00117 Glutamine amidotransferase class-I |
Function |
This enzyme is involved in the de novo synthesis of CTP, a precursor of DNA, RNA and phospholipids. Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as a source of nitrogen. This enzyme and its product, CTP, play a crucial role in the proliferation of activated lymphocytes and therefore in immunity. |
Biological Process |
GO:0006213 pyrimidine nucleoside metabolic process GO:0006220 pyrimidine nucleotide metabolic process GO:0006221 pyrimidine nucleotide biosynthetic process GO:0006241 CTP biosynthetic process GO:0006520 cellular amino acid metabolic process GO:0006541 glutamine metabolic process GO:0007159 leukocyte cell-cell adhesion GO:0009064 glutamine family amino acid metabolic process GO:0009116 nucleoside metabolic process GO:0009119 ribonucleoside metabolic process GO:0009141 nucleoside triphosphate metabolic process GO:0009142 nucleoside triphosphate biosynthetic process GO:0009147 pyrimidine nucleoside triphosphate metabolic process GO:0009148 pyrimidine nucleoside triphosphate biosynthetic process GO:0009163 nucleoside biosynthetic process GO:0009165 nucleotide biosynthetic process GO:0009199 ribonucleoside triphosphate metabolic process GO:0009201 ribonucleoside triphosphate biosynthetic process GO:0009208 pyrimidine ribonucleoside triphosphate metabolic process GO:0009209 pyrimidine ribonucleoside triphosphate biosynthetic process GO:0009218 pyrimidine ribonucleotide metabolic process GO:0009220 pyrimidine ribonucleotide biosynthetic process GO:0009260 ribonucleotide biosynthetic process GO:0015949 nucleobase-containing small molecule interconversion GO:0032943 mononuclear cell proliferation GO:0042098 T cell proliferation GO:0042100 B cell proliferation GO:0042110 T cell activation GO:0042113 B cell activation GO:0042455 ribonucleoside biosynthetic process GO:0042493 response to drug GO:0044210 'de novo' CTP biosynthetic process GO:0046036 CTP metabolic process GO:0046131 pyrimidine ribonucleoside metabolic process GO:0046132 pyrimidine ribonucleoside biosynthetic process GO:0046134 pyrimidine nucleoside biosynthetic process GO:0046390 ribose phosphate biosynthetic process GO:0046651 lymphocyte proliferation GO:0070486 leukocyte aggregation GO:0070489 T cell aggregation GO:0070661 leukocyte proliferation GO:0071593 lymphocyte aggregation GO:0072527 pyrimidine-containing compound metabolic process GO:0072528 pyrimidine-containing compound biosynthetic process GO:1901293 nucleoside phosphate biosynthetic process GO:1901605 alpha-amino acid metabolic process GO:1901657 glycosyl compound metabolic process GO:1901659 glycosyl compound biosynthetic process |
Molecular Function |
GO:0003883 CTP synthase activity GO:0016874 ligase activity GO:0016879 ligase activity, forming carbon-nitrogen bonds |
Cellular Component | - |
KEGG |
hsa00240 Pyrimidine metabolism hsa01100 Metabolic pathways |
Reactome |
R-HSA-1430728: Metabolism R-HSA-15869: Metabolism of nucleotides R-HSA-499943: Synthesis and interconversion of nucleotide di- and triphosphates |
Summary | |
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Symbol | CTPS1 |
Name | CTP synthase 1 |
Aliases | CTPS; CTP synthase; IMD24; CTP synthetase 1; UTP--ammonia ligase 1; cytidine 5'-triphosphate synthetase; cyt ...... |
Chromosomal Location | 1p34.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between CTPS1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
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Symbol | CTPS1 |
Name | CTP synthase 1 |
Aliases | CTPS; CTP synthase; IMD24; CTP synthetase 1; UTP--ammonia ligase 1; cytidine 5'-triphosphate synthetase; cyt ...... |
Chromosomal Location | 1p34.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of CTPS1 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | CTPS1 |
Name | CTP synthase 1 |
Aliases | CTPS; CTP synthase; IMD24; CTP synthetase 1; UTP--ammonia ligase 1; cytidine 5'-triphosphate synthetase; cyt ...... |
Chromosomal Location | 1p34.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of CTPS1 in various data sets.
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Points in the above scatter plot represent the mutation difference of CTPS1 in various data sets.
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Summary | |
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Symbol | CTPS1 |
Name | CTP synthase 1 |
Aliases | CTPS; CTP synthase; IMD24; CTP synthetase 1; UTP--ammonia ligase 1; cytidine 5'-triphosphate synthetase; cyt ...... |
Chromosomal Location | 1p34.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of CTPS1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | CTPS1 |
Name | CTP synthase 1 |
Aliases | CTPS; CTP synthase; IMD24; CTP synthetase 1; UTP--ammonia ligase 1; cytidine 5'-triphosphate synthetase; cyt ...... |
Chromosomal Location | 1p34.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of CTPS1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by CTPS1. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | CTPS1 |
Name | CTP synthase 1 |
Aliases | CTPS; CTP synthase; IMD24; CTP synthetase 1; UTP--ammonia ligase 1; cytidine 5'-triphosphate synthetase; cyt ...... |
Chromosomal Location | 1p34.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of CTPS1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | CTPS1 |
Name | CTP synthase 1 |
Aliases | CTPS; CTP synthase; IMD24; CTP synthetase 1; UTP--ammonia ligase 1; cytidine 5'-triphosphate synthetase; cyt ...... |
Chromosomal Location | 1p34.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of CTPS1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | CTPS1 |
Name | CTP synthase 1 |
Aliases | CTPS; CTP synthase; IMD24; CTP synthetase 1; UTP--ammonia ligase 1; cytidine 5'-triphosphate synthetase; cyt ...... |
Chromosomal Location | 1p34.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between CTPS1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | CTPS1 |
Name | CTP synthase 1 |
Aliases | CTPS; CTP synthase; IMD24; CTP synthetase 1; UTP--ammonia ligase 1; cytidine 5'-triphosphate synthetase; cyt ...... |
Chromosomal Location | 1p34.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting CTPS1 collected from DrugBank database. |
Details on drugs targeting CTPS1.
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