Summary | |
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Symbol | CWC27 |
Name | CWC27 spliceosome-associated protein homolog |
Aliases | NY-CO-10; SDCCAG-10; SDCCAG10; serologically defined colon cancer antigen 10; CWC27 spliceosome-associated p ...... |
Chromosomal Location | 5q12.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | - |
Domain |
PF00160 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD |
Function |
PPIases accelerate the folding of proteins. |
Biological Process |
GO:0000375 RNA splicing, via transesterification reactions GO:0000377 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile GO:0000398 mRNA splicing, via spliceosome GO:0000413 protein peptidyl-prolyl isomerization GO:0006397 mRNA processing GO:0006457 protein folding GO:0008380 RNA splicing GO:0018208 peptidyl-proline modification |
Molecular Function |
GO:0003755 peptidyl-prolyl cis-trans isomerase activity GO:0016853 isomerase activity GO:0016859 cis-trans isomerase activity |
Cellular Component |
GO:0005681 spliceosomal complex GO:0071013 catalytic step 2 spliceosome |
KEGG | - |
Reactome |
R-HSA-74160: Gene Expression R-HSA-72203: Processing of Capped Intron-Containing Pre-mRNA R-HSA-72172: mRNA Splicing R-HSA-72163: mRNA Splicing - Major Pathway |
Summary | |
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Symbol | CWC27 |
Name | CWC27 spliceosome-associated protein homolog |
Aliases | NY-CO-10; SDCCAG-10; SDCCAG10; serologically defined colon cancer antigen 10; CWC27 spliceosome-associated p ...... |
Chromosomal Location | 5q12.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between CWC27 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | CWC27 |
Name | CWC27 spliceosome-associated protein homolog |
Aliases | NY-CO-10; SDCCAG-10; SDCCAG10; serologically defined colon cancer antigen 10; CWC27 spliceosome-associated p ...... |
Chromosomal Location | 5q12.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of CWC27 in screening data sets for detecting immune reponses.
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Summary | |
---|---|
Symbol | CWC27 |
Name | CWC27 spliceosome-associated protein homolog |
Aliases | NY-CO-10; SDCCAG-10; SDCCAG10; serologically defined colon cancer antigen 10; CWC27 spliceosome-associated p ...... |
Chromosomal Location | 5q12.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of CWC27 in various data sets.
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Points in the above scatter plot represent the mutation difference of CWC27 in various data sets.
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Summary | |
---|---|
Symbol | CWC27 |
Name | CWC27 spliceosome-associated protein homolog |
Aliases | NY-CO-10; SDCCAG-10; SDCCAG10; serologically defined colon cancer antigen 10; CWC27 spliceosome-associated p ...... |
Chromosomal Location | 5q12.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of CWC27. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | CWC27 |
Name | CWC27 spliceosome-associated protein homolog |
Aliases | NY-CO-10; SDCCAG-10; SDCCAG10; serologically defined colon cancer antigen 10; CWC27 spliceosome-associated p ...... |
Chromosomal Location | 5q12.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of CWC27. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by CWC27. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | CWC27 |
Name | CWC27 spliceosome-associated protein homolog |
Aliases | NY-CO-10; SDCCAG-10; SDCCAG10; serologically defined colon cancer antigen 10; CWC27 spliceosome-associated p ...... |
Chromosomal Location | 5q12.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of CWC27. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | CWC27 |
Name | CWC27 spliceosome-associated protein homolog |
Aliases | NY-CO-10; SDCCAG-10; SDCCAG10; serologically defined colon cancer antigen 10; CWC27 spliceosome-associated p ...... |
Chromosomal Location | 5q12.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of CWC27 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | CWC27 |
Name | CWC27 spliceosome-associated protein homolog |
Aliases | NY-CO-10; SDCCAG-10; SDCCAG10; serologically defined colon cancer antigen 10; CWC27 spliceosome-associated p ...... |
Chromosomal Location | 5q12.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between CWC27 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | CWC27 |
Name | CWC27 spliceosome-associated protein homolog |
Aliases | NY-CO-10; SDCCAG-10; SDCCAG10; serologically defined colon cancer antigen 10; CWC27 spliceosome-associated p ...... |
Chromosomal Location | 5q12.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting CWC27 collected from DrugBank database. |
There is no record. |