Browse CWC27

Summary
SymbolCWC27
NameCWC27 spliceosome-associated protein homolog
Aliases NY-CO-10; SDCCAG-10; SDCCAG10; serologically defined colon cancer antigen 10; CWC27 spliceosome-associated p ......
Chromosomal Location5q12.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location -
Domain PF00160 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD
Function

PPIases accelerate the folding of proteins.

> Gene Ontology
 
Biological Process GO:0000375 RNA splicing, via transesterification reactions
GO:0000377 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile
GO:0000398 mRNA splicing, via spliceosome
GO:0000413 protein peptidyl-prolyl isomerization
GO:0006397 mRNA processing
GO:0006457 protein folding
GO:0008380 RNA splicing
GO:0018208 peptidyl-proline modification
Molecular Function GO:0003755 peptidyl-prolyl cis-trans isomerase activity
GO:0016853 isomerase activity
GO:0016859 cis-trans isomerase activity
Cellular Component GO:0005681 spliceosomal complex
GO:0071013 catalytic step 2 spliceosome
> KEGG and Reactome Pathway
 
KEGG -
Reactome R-HSA-74160: Gene Expression
R-HSA-72203: Processing of Capped Intron-Containing Pre-mRNA
R-HSA-72172: mRNA Splicing
R-HSA-72163: mRNA Splicing - Major Pathway
Summary
SymbolCWC27
NameCWC27 spliceosome-associated protein homolog
Aliases NY-CO-10; SDCCAG-10; SDCCAG10; serologically defined colon cancer antigen 10; CWC27 spliceosome-associated p ......
Chromosomal Location5q12.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between CWC27 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.

Summary
SymbolCWC27
NameCWC27 spliceosome-associated protein homolog
Aliases NY-CO-10; SDCCAG-10; SDCCAG10; serologically defined colon cancer antigen 10; CWC27 spliceosome-associated p ......
Chromosomal Location5q12.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of CWC27 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NS NA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell logFC: -2.68; FDR: 0.00545 Resistant to T cell-mediated killing
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NS NA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NS NA/NS
24476824shRNAmelanomaB16Primary screen NA/NS NA/NS
24476824shRNAmelanomaB16Secondary screen NA/NS NA/NS
Summary
SymbolCWC27
NameCWC27 spliceosome-associated protein homolog
Aliases NY-CO-10; SDCCAG-10; SDCCAG10; serologically defined colon cancer antigen 10; CWC27 spliceosome-associated p ......
Chromosomal Location5q12.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of CWC27 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14120.030.889
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)650.0770.965
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.0070.996
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.2130.478
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.1570.926
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47-0.2880.886
729033130MelanomaallAnti-PD-1 (nivolumab) 2623-0.0630.846
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-0.0150.991
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-0.1150.937
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.1580.897
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.710.689
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.0170.809
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of CWC27 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27737.407.40.0709
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27597.407.40.096
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21174.804.81
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13117.707.71
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38270001
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22130001
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolCWC27
NameCWC27 spliceosome-associated protein homolog
Aliases NY-CO-10; SDCCAG-10; SDCCAG10; serologically defined colon cancer antigen 10; CWC27 spliceosome-associated p ......
Chromosomal Location5q12.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of CWC27. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolCWC27
NameCWC27 spliceosome-associated protein homolog
Aliases NY-CO-10; SDCCAG-10; SDCCAG10; serologically defined colon cancer antigen 10; CWC27 spliceosome-associated p ......
Chromosomal Location5q12.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of CWC27. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by CWC27.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolCWC27
NameCWC27 spliceosome-associated protein homolog
Aliases NY-CO-10; SDCCAG-10; SDCCAG10; serologically defined colon cancer antigen 10; CWC27 spliceosome-associated p ......
Chromosomal Location5q12.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of CWC27. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolCWC27
NameCWC27 spliceosome-associated protein homolog
Aliases NY-CO-10; SDCCAG-10; SDCCAG10; serologically defined colon cancer antigen 10; CWC27 spliceosome-associated p ......
Chromosomal Location5q12.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of CWC27 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolCWC27
NameCWC27 spliceosome-associated protein homolog
Aliases NY-CO-10; SDCCAG-10; SDCCAG10; serologically defined colon cancer antigen 10; CWC27 spliceosome-associated p ......
Chromosomal Location5q12.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between CWC27 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolCWC27
NameCWC27 spliceosome-associated protein homolog
Aliases NY-CO-10; SDCCAG-10; SDCCAG10; serologically defined colon cancer antigen 10; CWC27 spliceosome-associated p ......
Chromosomal Location5q12.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting CWC27 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.