Summary | |
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Symbol | CXCL10 |
Name | chemokine (C-X-C motif) ligand 10 |
Aliases | IFI10; IP-10; crg-2; mob-1; gIP-10; INP10; SCYB10; small inducible cytokine subfamily B (Cys-X-Cys), member ...... |
Chromosomal Location | 4q21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Secreted. |
Domain |
PF00048 Small cytokines (intecrine/chemokine) |
Function |
Chemotactic for monocytes and T-lymphocytes. Binds to CXCR3. |
Biological Process |
GO:0000768 syncytium formation by plasma membrane fusion GO:0001525 angiogenesis GO:0002237 response to molecule of bacterial origin GO:0002548 monocyte chemotaxis GO:0002685 regulation of leukocyte migration GO:0002687 positive regulation of leukocyte migration GO:0002688 regulation of leukocyte chemotaxis GO:0002690 positive regulation of leukocyte chemotaxis GO:0003013 circulatory system process GO:0003158 endothelium development GO:0003159 morphogenesis of an endothelium GO:0006140 regulation of nucleotide metabolic process GO:0006816 calcium ion transport GO:0006874 cellular calcium ion homeostasis GO:0006875 cellular metal ion homeostasis GO:0006949 syncytium formation GO:0007204 positive regulation of cytosolic calcium ion concentration GO:0007517 muscle organ development GO:0007520 myoblast fusion GO:0007584 response to nutrient GO:0008015 blood circulation GO:0009150 purine ribonucleotide metabolic process GO:0009187 cyclic nucleotide metabolic process GO:0009266 response to temperature stimulus GO:0009314 response to radiation GO:0009408 response to heat GO:0009409 response to cold GO:0009612 response to mechanical stimulus GO:0009615 response to virus GO:0009991 response to extracellular stimulus GO:0010212 response to ionizing radiation GO:0010332 response to gamma radiation GO:0010522 regulation of calcium ion transport into cytosol GO:0010524 positive regulation of calcium ion transport into cytosol GO:0010818 T cell chemotaxis GO:0010819 regulation of T cell chemotaxis GO:0010830 regulation of myotube differentiation GO:0010832 negative regulation of myotube differentiation GO:0010959 regulation of metal ion transport GO:0010996 response to auditory stimulus GO:0014902 myotube differentiation GO:0016525 negative regulation of angiogenesis GO:0019932 second-messenger-mediated signaling GO:0019933 cAMP-mediated signaling GO:0019935 cyclic-nucleotide-mediated signaling GO:0030335 positive regulation of cell migration GO:0030595 leukocyte chemotaxis GO:0030799 regulation of cyclic nucleotide metabolic process GO:0030801 positive regulation of cyclic nucleotide metabolic process GO:0030814 regulation of cAMP metabolic process GO:0030816 positive regulation of cAMP metabolic process GO:0031667 response to nutrient levels GO:0032103 positive regulation of response to external stimulus GO:0032496 response to lipopolysaccharide GO:0032844 regulation of homeostatic process GO:0032845 negative regulation of homeostatic process GO:0032846 positive regulation of homeostatic process GO:0033273 response to vitamin GO:0033280 response to vitamin D GO:0034242 negative regulation of syncytium formation by plasma membrane fusion GO:0034605 cellular response to heat GO:0034762 regulation of transmembrane transport GO:0034764 positive regulation of transmembrane transport GO:0034765 regulation of ion transmembrane transport GO:0034767 positive regulation of ion transmembrane transport GO:0035239 tube morphogenesis GO:0040017 positive regulation of locomotion GO:0042118 endothelial cell activation GO:0042692 muscle cell differentiation GO:0043270 positive regulation of ion transport GO:0043949 regulation of cAMP-mediated signaling GO:0043950 positive regulation of cAMP-mediated signaling GO:0045445 myoblast differentiation GO:0045661 regulation of myoblast differentiation GO:0045662 negative regulation of myoblast differentiation GO:0045765 regulation of angiogenesis GO:0045981 positive regulation of nucleotide metabolic process GO:0046058 cAMP metabolic process GO:0048247 lymphocyte chemotaxis GO:0048514 blood vessel morphogenesis GO:0050900 leukocyte migration GO:0050920 regulation of chemotaxis GO:0050921 positive regulation of chemotaxis GO:0051146 striated muscle cell differentiation GO:0051147 regulation of muscle cell differentiation GO:0051148 negative regulation of muscle cell differentiation GO:0051153 regulation of striated muscle cell differentiation GO:0051154 negative regulation of striated muscle cell differentiation GO:0051208 sequestering of calcium ion GO:0051209 release of sequestered calcium ion into cytosol GO:0051235 maintenance of location GO:0051238 sequestering of metal ion GO:0051272 positive regulation of cellular component movement GO:0051279 regulation of release of sequestered calcium ion into cytosol GO:0051281 positive regulation of release of sequestered calcium ion into cytosol GO:0051282 regulation of sequestering of calcium ion GO:0051283 negative regulation of sequestering of calcium ion GO:0051480 regulation of cytosolic calcium ion concentration GO:0051607 defense response to virus GO:0051924 regulation of calcium ion transport GO:0051928 positive regulation of calcium ion transport GO:0055074 calcium ion homeostasis GO:0060142 regulation of syncytium formation by plasma membrane fusion GO:0060326 cell chemotaxis GO:0060401 cytosolic calcium ion transport GO:0060402 calcium ion transport into cytosol GO:0060562 epithelial tube morphogenesis GO:0061154 endothelial tube morphogenesis GO:0070098 chemokine-mediated signaling pathway GO:0070509 calcium ion import GO:0070588 calcium ion transmembrane transport GO:0070838 divalent metal ion transport GO:0071216 cellular response to biotic stimulus GO:0071219 cellular response to molecule of bacterial origin GO:0071222 cellular response to lipopolysaccharide GO:0071396 cellular response to lipid GO:0071674 mononuclear cell migration GO:0071675 regulation of mononuclear cell migration GO:0071677 positive regulation of mononuclear cell migration GO:0072503 cellular divalent inorganic cation homeostasis GO:0072507 divalent inorganic cation homeostasis GO:0072511 divalent inorganic cation transport GO:0072676 lymphocyte migration GO:0072678 T cell migration GO:0090025 regulation of monocyte chemotaxis GO:0090026 positive regulation of monocyte chemotaxis GO:0090279 regulation of calcium ion import GO:0090280 positive regulation of calcium ion import GO:0097529 myeloid leukocyte migration GO:0097553 calcium ion transmembrane import into cytosol GO:0098542 defense response to other organism GO:1900542 regulation of purine nucleotide metabolic process GO:1900544 positive regulation of purine nucleotide metabolic process GO:1901342 regulation of vasculature development GO:1901343 negative regulation of vasculature development GO:1901509 regulation of endothelial tube morphogenesis GO:1901623 regulation of lymphocyte chemotaxis GO:1901739 regulation of myoblast fusion GO:1901740 negative regulation of myoblast fusion GO:1902656 calcium ion import into cytosol GO:1903169 regulation of calcium ion transmembrane transport GO:1904062 regulation of cation transmembrane transport GO:1904064 positive regulation of cation transmembrane transport GO:1904427 positive regulation of calcium ion transmembrane transport GO:1905330 regulation of morphogenesis of an epithelium GO:2000021 regulation of ion homeostasis GO:2000147 positive regulation of cell motility GO:2000181 negative regulation of blood vessel morphogenesis GO:2000401 regulation of lymphocyte migration GO:2000403 positive regulation of lymphocyte migration GO:2000404 regulation of T cell migration GO:2000406 positive regulation of T cell migration |
Molecular Function |
GO:0001664 G-protein coupled receptor binding GO:0005125 cytokine activity GO:0005126 cytokine receptor binding GO:0005539 glycosaminoglycan binding GO:0008009 chemokine activity GO:0008201 heparin binding GO:0008603 cAMP-dependent protein kinase regulator activity GO:0019207 kinase regulator activity GO:0019887 protein kinase regulator activity GO:0042379 chemokine receptor binding GO:0045236 CXCR chemokine receptor binding GO:0048248 CXCR3 chemokine receptor binding GO:1901681 sulfur compound binding |
Cellular Component |
GO:0009897 external side of plasma membrane GO:0098552 side of membrane |
KEGG |
hsa04060 Cytokine-cytokine receptor interaction hsa04062 Chemokine signaling pathway hsa04620 Toll-like receptor signaling pathway hsa04622 RIG-I-like receptor signaling pathway hsa04623 Cytosolic DNA-sensing pathway hsa04668 TNF signaling pathway |
Reactome |
R-HSA-380108: Chemokine receptors bind chemokines R-HSA-373076: Class A/1 (Rhodopsin-like receptors) R-HSA-1280215: Cytokine Signaling in Immune system R-HSA-418594: G alpha (i) signalling events R-HSA-388396: GPCR downstream signaling R-HSA-500792: GPCR ligand binding R-HSA-168256: Immune System R-HSA-6783783: Interleukin-10 signaling R-HSA-375276: Peptide ligand-binding receptors R-HSA-162582: Signal Transduction R-HSA-372790: Signaling by GPCR R-HSA-449147: Signaling by Interleukins |
Summary | |
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Symbol | CXCL10 |
Name | chemokine (C-X-C motif) ligand 10 |
Aliases | IFI10; IP-10; crg-2; mob-1; gIP-10; INP10; SCYB10; small inducible cytokine subfamily B (Cys-X-Cys), member ...... |
Chromosomal Location | 4q21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between CXCL10 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between CXCL10 and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | CXCL10 |
Name | chemokine (C-X-C motif) ligand 10 |
Aliases | IFI10; IP-10; crg-2; mob-1; gIP-10; INP10; SCYB10; small inducible cytokine subfamily B (Cys-X-Cys), member ...... |
Chromosomal Location | 4q21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of CXCL10 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | CXCL10 |
Name | chemokine (C-X-C motif) ligand 10 |
Aliases | IFI10; IP-10; crg-2; mob-1; gIP-10; INP10; SCYB10; small inducible cytokine subfamily B (Cys-X-Cys), member ...... |
Chromosomal Location | 4q21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of CXCL10 in various data sets.
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Points in the above scatter plot represent the mutation difference of CXCL10 in various data sets.
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Summary | |
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Symbol | CXCL10 |
Name | chemokine (C-X-C motif) ligand 10 |
Aliases | IFI10; IP-10; crg-2; mob-1; gIP-10; INP10; SCYB10; small inducible cytokine subfamily B (Cys-X-Cys), member ...... |
Chromosomal Location | 4q21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of CXCL10. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | CXCL10 |
Name | chemokine (C-X-C motif) ligand 10 |
Aliases | IFI10; IP-10; crg-2; mob-1; gIP-10; INP10; SCYB10; small inducible cytokine subfamily B (Cys-X-Cys), member ...... |
Chromosomal Location | 4q21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of CXCL10. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by CXCL10. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | CXCL10 |
Name | chemokine (C-X-C motif) ligand 10 |
Aliases | IFI10; IP-10; crg-2; mob-1; gIP-10; INP10; SCYB10; small inducible cytokine subfamily B (Cys-X-Cys), member ...... |
Chromosomal Location | 4q21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of CXCL10. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | CXCL10 |
Name | chemokine (C-X-C motif) ligand 10 |
Aliases | IFI10; IP-10; crg-2; mob-1; gIP-10; INP10; SCYB10; small inducible cytokine subfamily B (Cys-X-Cys), member ...... |
Chromosomal Location | 4q21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of CXCL10 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | CXCL10 |
Name | chemokine (C-X-C motif) ligand 10 |
Aliases | IFI10; IP-10; crg-2; mob-1; gIP-10; INP10; SCYB10; small inducible cytokine subfamily B (Cys-X-Cys), member ...... |
Chromosomal Location | 4q21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between CXCL10 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | CXCL10 |
Name | chemokine (C-X-C motif) ligand 10 |
Aliases | IFI10; IP-10; crg-2; mob-1; gIP-10; INP10; SCYB10; small inducible cytokine subfamily B (Cys-X-Cys), member ...... |
Chromosomal Location | 4q21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting CXCL10 collected from DrugBank database. |
Details on drugs targeting CXCL10.
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