Summary | |
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Symbol | CXCL12 |
Name | chemokine (C-X-C motif) ligand 12 |
Aliases | SCYB12; SDF-1a; SDF-1b; PBSF; TLSF-a; TLSF-b; TPAR1; SDF1A; SDF1B; SDF1; stromal cell-derived factor 1; IRH; ...... |
Chromosomal Location | 10q11.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Secreted. |
Domain |
PF00048 Small cytokines (intecrine/chemokine) |
Function |
Chemoattractant active on T-lymphocytes and monocytes but not neutrophils. Activates the C-X-C chemokine receptor CXCR4 to induce a rapid and transient rise in the level of intracellular calcium ions and chemotaxis. SDF-1-beta(3-72) and SDF-1-alpha(3-67) show a reduced chemotactic activity. Binding to cell surface proteoglycans seems to inhibit formation of SDF-1-alpha(3-67) and thus to preserve activity on local sites. Also binds to atypical chemokine receptor ACKR3, which activates the beta-arrestin pathway and acts as a scavenger receptor for SDF-1. Binds to the allosteric site (site 2) of integrins and activates integrins ITGAV:ITGB3, ITGA4:ITGB1 and ITGA5:ITGB1 in a CXCR4-independent manner (PubMed:29301984). Acts as a positive regulator of monocyte migration and a negative regulator of monocyte adhesion via the LYN kinase. Stimulates migration of monocytes and T-lymphocytes through its receptors, CXCR4 and ACKR3, and decreases monocyte adherence to surfaces coated with ICAM-1, a ligand for beta-2 integrins. SDF1A/CXCR4 signaling axis inhibits beta-2 integrin LFA-1 mediated adhesion of monocytes to ICAM-1 through LYN kinase. Inhibits CXCR4-mediated infection by T-cell line-adapted HIV-1. Plays a protective role after myocardial infarction. Induces down-regulation and internalization of ACKR3 expressed in various cells. Has several critical functions during embryonic development; required for B-cell lymphopoiesis, myelopoiesis in bone marrow and heart ventricular septum formation. Stimulates the proliferation of bone marrow-derived B-cell progenitors in the presence of IL7 as well as growth of stromal cell-dependent pre-B-cells (By similarity). |
Biological Process |
GO:0001558 regulation of cell growth GO:0001666 response to hypoxia GO:0001764 neuron migration GO:0001935 endothelial cell proliferation GO:0001936 regulation of endothelial cell proliferation GO:0001938 positive regulation of endothelial cell proliferation GO:0002548 monocyte chemotaxis GO:0002683 negative regulation of immune system process GO:0002685 regulation of leukocyte migration GO:0002686 negative regulation of leukocyte migration GO:0002687 positive regulation of leukocyte migration GO:0002688 regulation of leukocyte chemotaxis GO:0002690 positive regulation of leukocyte chemotaxis GO:0002691 regulation of cellular extravasation GO:0002692 negative regulation of cellular extravasation GO:0003013 circulatory system process GO:0006816 calcium ion transport GO:0006874 cellular calcium ion homeostasis GO:0006875 cellular metal ion homeostasis GO:0007015 actin filament organization GO:0007159 leukocyte cell-cell adhesion GO:0007162 negative regulation of cell adhesion GO:0007409 axonogenesis GO:0007411 axon guidance GO:0007626 locomotory behavior GO:0008015 blood circulation GO:0008064 regulation of actin polymerization or depolymerization GO:0008154 actin polymerization or depolymerization GO:0008344 adult locomotory behavior GO:0008361 regulation of cell size GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage GO:0009266 response to temperature stimulus GO:0009314 response to radiation GO:0009408 response to heat GO:0009612 response to mechanical stimulus GO:0009615 response to virus GO:0010720 positive regulation of cell development GO:0010769 regulation of cell morphogenesis involved in differentiation GO:0010770 positive regulation of cell morphogenesis involved in differentiation GO:0010959 regulation of metal ion transport GO:0010975 regulation of neuron projection development GO:0010976 positive regulation of neuron projection development GO:0014046 dopamine secretion GO:0014059 regulation of dopamine secretion GO:0015837 amine transport GO:0015844 monoamine transport GO:0015850 organic hydroxy compound transport GO:0015872 dopamine transport GO:0016049 cell growth GO:0021537 telencephalon development GO:0021885 forebrain cell migration GO:0022029 telencephalon cell migration GO:0022407 regulation of cell-cell adhesion GO:0022408 negative regulation of cell-cell adhesion GO:0022604 regulation of cell morphogenesis GO:0030307 positive regulation of cell growth GO:0030335 positive regulation of cell migration GO:0030336 negative regulation of cell migration GO:0030516 regulation of axon extension GO:0030534 adult behavior GO:0030595 leukocyte chemotaxis GO:0030832 regulation of actin filament length GO:0030900 forebrain development GO:0031099 regeneration GO:0031100 animal organ regeneration GO:0031346 positive regulation of cell projection organization GO:0032103 positive regulation of response to external stimulus GO:0032535 regulation of cellular component size GO:0032956 regulation of actin cytoskeleton organization GO:0032970 regulation of actin filament-based process GO:0033603 positive regulation of dopamine secretion GO:0033605 positive regulation of catecholamine secretion GO:0036293 response to decreased oxygen levels GO:0040013 negative regulation of locomotion GO:0040017 positive regulation of locomotion GO:0043270 positive regulation of ion transport GO:0043434 response to peptide hormone GO:0044708 single-organism behavior GO:0045123 cellular extravasation GO:0045666 positive regulation of neuron differentiation GO:0045773 positive regulation of axon extension GO:0045785 positive regulation of cell adhesion GO:0045927 positive regulation of growth GO:0048588 developmental cell growth GO:0048638 regulation of developmental growth GO:0048639 positive regulation of developmental growth GO:0048667 cell morphogenesis involved in neuron differentiation GO:0048675 axon extension GO:0048841 regulation of axon extension involved in axon guidance GO:0048842 positive regulation of axon extension involved in axon guidance GO:0048846 axon extension involved in axon guidance GO:0050432 catecholamine secretion GO:0050433 regulation of catecholamine secretion GO:0050673 epithelial cell proliferation GO:0050678 regulation of epithelial cell proliferation GO:0050679 positive regulation of epithelial cell proliferation GO:0050769 positive regulation of neurogenesis GO:0050770 regulation of axonogenesis GO:0050772 positive regulation of axonogenesis GO:0050900 leukocyte migration GO:0050901 leukocyte tethering or rolling GO:0050918 positive chemotaxis GO:0050920 regulation of chemotaxis GO:0050921 positive regulation of chemotaxis GO:0050926 regulation of positive chemotaxis GO:0050927 positive regulation of positive chemotaxis GO:0050930 induction of positive chemotaxis GO:0051047 positive regulation of secretion GO:0051271 negative regulation of cellular component movement GO:0051272 positive regulation of cellular component movement GO:0051493 regulation of cytoskeleton organization GO:0051924 regulation of calcium ion transport GO:0051928 positive regulation of calcium ion transport GO:0051937 catecholamine transport GO:0051952 regulation of amine transport GO:0051954 positive regulation of amine transport GO:0051962 positive regulation of nervous system development GO:0055074 calcium ion homeostasis GO:0060326 cell chemotaxis GO:0060560 developmental growth involved in morphogenesis GO:0061387 regulation of extent of cell growth GO:0061564 axon development GO:0061756 leukocyte adhesion to vascular endothelial cell GO:0070098 chemokine-mediated signaling pathway GO:0070482 response to oxygen levels GO:0070509 calcium ion import GO:0070838 divalent metal ion transport GO:0071674 mononuclear cell migration GO:0071675 regulation of mononuclear cell migration GO:0071677 positive regulation of mononuclear cell migration GO:0071887 leukocyte apoptotic process GO:0072503 cellular divalent inorganic cation homeostasis GO:0072507 divalent inorganic cation homeostasis GO:0072511 divalent inorganic cation transport GO:0072676 lymphocyte migration GO:0072678 T cell migration GO:0090025 regulation of monocyte chemotaxis GO:0090026 positive regulation of monocyte chemotaxis GO:0090066 regulation of anatomical structure size GO:0090279 regulation of calcium ion import GO:0090280 positive regulation of calcium ion import GO:0097193 intrinsic apoptotic signaling pathway GO:0097485 neuron projection guidance GO:0097529 myeloid leukocyte migration GO:1901652 response to peptide GO:1902229 regulation of intrinsic apoptotic signaling pathway in response to DNA damage GO:1902230 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage GO:1902284 neuron projection extension involved in neuron projection guidance GO:1902532 negative regulation of intracellular signal transduction GO:1902667 regulation of axon guidance GO:1902669 positive regulation of axon guidance GO:1903037 regulation of leukocyte cell-cell adhesion GO:1903038 negative regulation of leukocyte cell-cell adhesion GO:1903236 regulation of leukocyte tethering or rolling GO:1903237 negative regulation of leukocyte tethering or rolling GO:1903532 positive regulation of secretion by cell GO:1904994 regulation of leukocyte adhesion to vascular endothelial cell GO:1904995 negative regulation of leukocyte adhesion to vascular endothelial cell GO:1990138 neuron projection extension GO:2000106 regulation of leukocyte apoptotic process GO:2000107 negative regulation of leukocyte apoptotic process GO:2000146 negative regulation of cell motility GO:2000147 positive regulation of cell motility GO:2000401 regulation of lymphocyte migration GO:2000403 positive regulation of lymphocyte migration GO:2000404 regulation of T cell migration GO:2000406 positive regulation of T cell migration GO:2001020 regulation of response to DNA damage stimulus GO:2001021 negative regulation of response to DNA damage stimulus GO:2001233 regulation of apoptotic signaling pathway GO:2001234 negative regulation of apoptotic signaling pathway GO:2001242 regulation of intrinsic apoptotic signaling pathway GO:2001243 negative regulation of intrinsic apoptotic signaling pathway |
Molecular Function |
GO:0001664 G-protein coupled receptor binding GO:0005125 cytokine activity GO:0005126 cytokine receptor binding GO:0008009 chemokine activity GO:0008083 growth factor activity GO:0042056 chemoattractant activity GO:0042379 chemokine receptor binding GO:0045236 CXCR chemokine receptor binding |
Cellular Component |
GO:0009897 external side of plasma membrane GO:0098552 side of membrane |
KEGG |
hsa04060 Cytokine-cytokine receptor interaction hsa04062 Chemokine signaling pathway hsa04064 NF-kappa B signaling pathway hsa04360 Axon guidance hsa04670 Leukocyte transendothelial migration hsa04672 Intestinal immune network for IgA production |
Reactome |
R-HSA-380108: Chemokine receptors bind chemokines R-HSA-373076: Class A/1 (Rhodopsin-like receptors) R-HSA-418594: G alpha (i) signalling events R-HSA-388396: GPCR downstream signaling R-HSA-500792: GPCR ligand binding R-HSA-1251985: Nuclear signaling by ERBB4 R-HSA-375276: Peptide ligand-binding receptors R-HSA-162582: Signal Transduction R-HSA-1236394: Signaling by ERBB4 R-HSA-372790: Signaling by GPCR |
Summary | |
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Symbol | CXCL12 |
Name | chemokine (C-X-C motif) ligand 12 |
Aliases | SCYB12; SDF-1a; SDF-1b; PBSF; TLSF-a; TLSF-b; TPAR1; SDF1A; SDF1B; SDF1; stromal cell-derived factor 1; IRH; ...... |
Chromosomal Location | 10q11.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between CXCL12 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between CXCL12 and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | CXCL12 |
Name | chemokine (C-X-C motif) ligand 12 |
Aliases | SCYB12; SDF-1a; SDF-1b; PBSF; TLSF-a; TLSF-b; TPAR1; SDF1A; SDF1B; SDF1; stromal cell-derived factor 1; IRH; ...... |
Chromosomal Location | 10q11.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of CXCL12 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | CXCL12 |
Name | chemokine (C-X-C motif) ligand 12 |
Aliases | SCYB12; SDF-1a; SDF-1b; PBSF; TLSF-a; TLSF-b; TPAR1; SDF1A; SDF1B; SDF1; stromal cell-derived factor 1; IRH; ...... |
Chromosomal Location | 10q11.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of CXCL12 in various data sets.
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Points in the above scatter plot represent the mutation difference of CXCL12 in various data sets.
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Summary | |
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Symbol | CXCL12 |
Name | chemokine (C-X-C motif) ligand 12 |
Aliases | SCYB12; SDF-1a; SDF-1b; PBSF; TLSF-a; TLSF-b; TPAR1; SDF1A; SDF1B; SDF1; stromal cell-derived factor 1; IRH; ...... |
Chromosomal Location | 10q11.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of CXCL12. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | CXCL12 |
Name | chemokine (C-X-C motif) ligand 12 |
Aliases | SCYB12; SDF-1a; SDF-1b; PBSF; TLSF-a; TLSF-b; TPAR1; SDF1A; SDF1B; SDF1; stromal cell-derived factor 1; IRH; ...... |
Chromosomal Location | 10q11.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of CXCL12. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by CXCL12. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | CXCL12 |
Name | chemokine (C-X-C motif) ligand 12 |
Aliases | SCYB12; SDF-1a; SDF-1b; PBSF; TLSF-a; TLSF-b; TPAR1; SDF1A; SDF1B; SDF1; stromal cell-derived factor 1; IRH; ...... |
Chromosomal Location | 10q11.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of CXCL12. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | CXCL12 |
Name | chemokine (C-X-C motif) ligand 12 |
Aliases | SCYB12; SDF-1a; SDF-1b; PBSF; TLSF-a; TLSF-b; TPAR1; SDF1A; SDF1B; SDF1; stromal cell-derived factor 1; IRH; ...... |
Chromosomal Location | 10q11.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of CXCL12 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | CXCL12 |
Name | chemokine (C-X-C motif) ligand 12 |
Aliases | SCYB12; SDF-1a; SDF-1b; PBSF; TLSF-a; TLSF-b; TPAR1; SDF1A; SDF1B; SDF1; stromal cell-derived factor 1; IRH; ...... |
Chromosomal Location | 10q11.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between CXCL12 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | CXCL12 |
Name | chemokine (C-X-C motif) ligand 12 |
Aliases | SCYB12; SDF-1a; SDF-1b; PBSF; TLSF-a; TLSF-b; TPAR1; SDF1A; SDF1B; SDF1; stromal cell-derived factor 1; IRH; ...... |
Chromosomal Location | 10q11.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting CXCL12 collected from DrugBank database. |
Details on drugs targeting CXCL12.
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