Summary | |
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Symbol | CXCL14 |
Name | chemokine (C-X-C motif) ligand 14 |
Aliases | BRAK; NJAC; bolekine; Kec; MIP-2g; BMAC; breast and kidney; SCYB14; small inducible cytokine subfamily B (Cy ...... |
Chromosomal Location | 5q31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Secreted. |
Domain |
PF00048 Small cytokines (intecrine/chemokine) |
Function |
Potent chemoattractant for neutrophils, and weaker for dendritic cells. Not chemotactic for T-cells, B-cells, monocytes, natural killer cells or granulocytes. Does not inhibit proliferation of myeloid progenitors in colony formation assays. |
Biological Process |
GO:0002685 regulation of leukocyte migration GO:0002687 positive regulation of leukocyte migration GO:0002688 regulation of leukocyte chemotaxis GO:0002690 positive regulation of leukocyte chemotaxis GO:0007423 sensory organ development GO:0030335 positive regulation of cell migration GO:0030595 leukocyte chemotaxis GO:0032103 positive regulation of response to external stimulus GO:0035747 natural killer cell chemotaxis GO:0040017 positive regulation of locomotion GO:0042692 muscle cell differentiation GO:0043583 ear development GO:0045445 myoblast differentiation GO:0045661 regulation of myoblast differentiation GO:0045662 negative regulation of myoblast differentiation GO:0048247 lymphocyte chemotaxis GO:0048839 inner ear development GO:0050900 leukocyte migration GO:0050920 regulation of chemotaxis GO:0050921 positive regulation of chemotaxis GO:0051147 regulation of muscle cell differentiation GO:0051148 negative regulation of muscle cell differentiation GO:0051272 positive regulation of cellular component movement GO:0060326 cell chemotaxis GO:0072676 lymphocyte migration GO:1901623 regulation of lymphocyte chemotaxis GO:2000147 positive regulation of cell motility GO:2000401 regulation of lymphocyte migration GO:2000403 positive regulation of lymphocyte migration GO:2000501 regulation of natural killer cell chemotaxis GO:2000503 positive regulation of natural killer cell chemotaxis |
Molecular Function |
GO:0001664 G-protein coupled receptor binding GO:0005125 cytokine activity GO:0005126 cytokine receptor binding GO:0008009 chemokine activity GO:0042379 chemokine receptor binding |
Cellular Component | - |
KEGG |
hsa04060 Cytokine-cytokine receptor interaction |
Reactome | - |
Summary | |
---|---|
Symbol | CXCL14 |
Name | chemokine (C-X-C motif) ligand 14 |
Aliases | BRAK; NJAC; bolekine; Kec; MIP-2g; BMAC; breast and kidney; SCYB14; small inducible cytokine subfamily B (Cy ...... |
Chromosomal Location | 5q31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between CXCL14 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | CXCL14 |
Name | chemokine (C-X-C motif) ligand 14 |
Aliases | BRAK; NJAC; bolekine; Kec; MIP-2g; BMAC; breast and kidney; SCYB14; small inducible cytokine subfamily B (Cy ...... |
Chromosomal Location | 5q31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of CXCL14 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | CXCL14 |
Name | chemokine (C-X-C motif) ligand 14 |
Aliases | BRAK; NJAC; bolekine; Kec; MIP-2g; BMAC; breast and kidney; SCYB14; small inducible cytokine subfamily B (Cy ...... |
Chromosomal Location | 5q31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of CXCL14 in various data sets.
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Points in the above scatter plot represent the mutation difference of CXCL14 in various data sets.
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Summary | |
---|---|
Symbol | CXCL14 |
Name | chemokine (C-X-C motif) ligand 14 |
Aliases | BRAK; NJAC; bolekine; Kec; MIP-2g; BMAC; breast and kidney; SCYB14; small inducible cytokine subfamily B (Cy ...... |
Chromosomal Location | 5q31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of CXCL14. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | CXCL14 |
Name | chemokine (C-X-C motif) ligand 14 |
Aliases | BRAK; NJAC; bolekine; Kec; MIP-2g; BMAC; breast and kidney; SCYB14; small inducible cytokine subfamily B (Cy ...... |
Chromosomal Location | 5q31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of CXCL14. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by CXCL14. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | CXCL14 |
Name | chemokine (C-X-C motif) ligand 14 |
Aliases | BRAK; NJAC; bolekine; Kec; MIP-2g; BMAC; breast and kidney; SCYB14; small inducible cytokine subfamily B (Cy ...... |
Chromosomal Location | 5q31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of CXCL14. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | CXCL14 |
Name | chemokine (C-X-C motif) ligand 14 |
Aliases | BRAK; NJAC; bolekine; Kec; MIP-2g; BMAC; breast and kidney; SCYB14; small inducible cytokine subfamily B (Cy ...... |
Chromosomal Location | 5q31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of CXCL14 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | CXCL14 |
Name | chemokine (C-X-C motif) ligand 14 |
Aliases | BRAK; NJAC; bolekine; Kec; MIP-2g; BMAC; breast and kidney; SCYB14; small inducible cytokine subfamily B (Cy ...... |
Chromosomal Location | 5q31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between CXCL14 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | CXCL14 |
Name | chemokine (C-X-C motif) ligand 14 |
Aliases | BRAK; NJAC; bolekine; Kec; MIP-2g; BMAC; breast and kidney; SCYB14; small inducible cytokine subfamily B (Cy ...... |
Chromosomal Location | 5q31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting CXCL14 collected from DrugBank database. |
There is no record. |