Summary | |
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Symbol | CXCL17 |
Name | chemokine (C-X-C motif) ligand 17 |
Aliases | Dcip1; UNQ473; VCC1; VCC-1; C-X-C motif chemokine 17; VEGF co-regulated chemokine 1; dendritic cell and mono ...... |
Chromosomal Location | 19q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Secreted |
Domain |
PF15211 VEGF co-regulated chemokine 1 |
Function |
Chemokine that acts as chemoattractant for monocytes, macrophages and dendritic cells (PubMed:16455961, PubMed:23115081). Plays a role in angiogenesis and possibly in the development of tumors (PubMed:16989774, PubMed:23115081). Acts as an anti-inflammatory in the stomach (PubMed:23115081). May play a role in the innate defense against infections (PubMed:17307946). Activates the C-X-C chemokine receptor GPR35 to induce a rapid and transient rise in the level of intracellular calcium ions (PubMed:25411203). ; FUNCTION: 4-Cys CXCL17: seems exhibit much higher chemoattractant potency on monocytes and macrophages than 6-Cys CXCL17. |
Biological Process |
GO:0001525 angiogenesis GO:0048514 blood vessel morphogenesis |
Molecular Function | - |
Cellular Component | - |
KEGG | - |
Reactome | - |
Summary | |
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Symbol | CXCL17 |
Name | chemokine (C-X-C motif) ligand 17 |
Aliases | Dcip1; UNQ473; VCC1; VCC-1; C-X-C motif chemokine 17; VEGF co-regulated chemokine 1; dendritic cell and mono ...... |
Chromosomal Location | 19q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between CXCL17 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between CXCL17 and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | CXCL17 |
Name | chemokine (C-X-C motif) ligand 17 |
Aliases | Dcip1; UNQ473; VCC1; VCC-1; C-X-C motif chemokine 17; VEGF co-regulated chemokine 1; dendritic cell and mono ...... |
Chromosomal Location | 19q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of CXCL17 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | CXCL17 |
Name | chemokine (C-X-C motif) ligand 17 |
Aliases | Dcip1; UNQ473; VCC1; VCC-1; C-X-C motif chemokine 17; VEGF co-regulated chemokine 1; dendritic cell and mono ...... |
Chromosomal Location | 19q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of CXCL17 in various data sets.
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Points in the above scatter plot represent the mutation difference of CXCL17 in various data sets.
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Summary | |
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Symbol | CXCL17 |
Name | chemokine (C-X-C motif) ligand 17 |
Aliases | Dcip1; UNQ473; VCC1; VCC-1; C-X-C motif chemokine 17; VEGF co-regulated chemokine 1; dendritic cell and mono ...... |
Chromosomal Location | 19q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of CXCL17. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | CXCL17 |
Name | chemokine (C-X-C motif) ligand 17 |
Aliases | Dcip1; UNQ473; VCC1; VCC-1; C-X-C motif chemokine 17; VEGF co-regulated chemokine 1; dendritic cell and mono ...... |
Chromosomal Location | 19q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of CXCL17. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by CXCL17. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | CXCL17 |
Name | chemokine (C-X-C motif) ligand 17 |
Aliases | Dcip1; UNQ473; VCC1; VCC-1; C-X-C motif chemokine 17; VEGF co-regulated chemokine 1; dendritic cell and mono ...... |
Chromosomal Location | 19q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of CXCL17. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | CXCL17 |
Name | chemokine (C-X-C motif) ligand 17 |
Aliases | Dcip1; UNQ473; VCC1; VCC-1; C-X-C motif chemokine 17; VEGF co-regulated chemokine 1; dendritic cell and mono ...... |
Chromosomal Location | 19q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of CXCL17 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | CXCL17 |
Name | chemokine (C-X-C motif) ligand 17 |
Aliases | Dcip1; UNQ473; VCC1; VCC-1; C-X-C motif chemokine 17; VEGF co-regulated chemokine 1; dendritic cell and mono ...... |
Chromosomal Location | 19q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between CXCL17 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | CXCL17 |
Name | chemokine (C-X-C motif) ligand 17 |
Aliases | Dcip1; UNQ473; VCC1; VCC-1; C-X-C motif chemokine 17; VEGF co-regulated chemokine 1; dendritic cell and mono ...... |
Chromosomal Location | 19q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting CXCL17 collected from DrugBank database. |
There is no record. |