Summary | |
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Symbol | CXCR3 |
Name | chemokine (C-X-C motif) receptor 3 |
Aliases | CKR-L2; CMKAR3; IP10-R; MigR; CD183; GPR9; G protein-coupled receptor 9; Mig-R; IP-10 receptor; Mig receptor ...... |
Chromosomal Location | Xq13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Isoform 1: Cell membrane Multi-pass membrane protein ; SUBCELLULAR LOCATION: Isoform 2: Cell membrane Multi-pass membrane protein |
Domain |
PF00001 7 transmembrane receptor (rhodopsin family) |
Function |
Isoform 1: Receptor for the C-X-C chemokine CXCL9, CXCL10 and CXCL11 and mediates the proliferation, survival and angiogenic activity of human mesangial cells (HMC) through a heterotrimeric G-protein signaling pathway (PubMed:12782716). Binds to CCL21. Probably promotes cell chemotaxis response. ; FUNCTION: Isoform 2: Receptor for the C-X-C chemokine CXCL4 and also mediates the inhibitory activities of CXCL9, CXCL10 and CXCL11 on the proliferation, survival and angiogenic activity of human microvascular endothelial cells (HMVEC) through a cAMP-mediated signaling pathway (PubMed:12782716). Does not promote cell chemotaxis respons. Interaction with CXCL4 or CXCL10 leads to activation of the p38MAPK pathway and contributes to inhibition of angiogenesis. Overexpression in renal cancer cells down-regulates expression of the anti-apoptotic protein HMOX1 and promotes apoptosis. ; FUNCTION: Isoform 3: Mediates the activity of CXCL11. |
Biological Process |
GO:0001525 angiogenesis GO:0002685 regulation of leukocyte migration GO:0006874 cellular calcium ion homeostasis GO:0006875 cellular metal ion homeostasis GO:0007204 positive regulation of cytosolic calcium ion concentration GO:0010818 T cell chemotaxis GO:0019722 calcium-mediated signaling GO:0019932 second-messenger-mediated signaling GO:0030595 leukocyte chemotaxis GO:0048247 lymphocyte chemotaxis GO:0048514 blood vessel morphogenesis GO:0050900 leukocyte migration GO:0051480 regulation of cytosolic calcium ion concentration GO:0055074 calcium ion homeostasis GO:0060326 cell chemotaxis GO:0070098 chemokine-mediated signaling pathway GO:0072503 cellular divalent inorganic cation homeostasis GO:0072507 divalent inorganic cation homeostasis GO:0072676 lymphocyte migration GO:0072678 T cell migration |
Molecular Function |
GO:0001637 G-protein coupled chemoattractant receptor activity GO:0001653 peptide receptor activity GO:0004896 cytokine receptor activity GO:0004950 chemokine receptor activity GO:0008528 G-protein coupled peptide receptor activity GO:0016494 C-X-C chemokine receptor activity GO:0019955 cytokine binding GO:0019956 chemokine binding |
Cellular Component |
GO:0009897 external side of plasma membrane GO:0098552 side of membrane |
KEGG |
hsa04060 Cytokine-cytokine receptor interaction hsa04062 Chemokine signaling pathway |
Reactome |
R-HSA-380108: Chemokine receptors bind chemokines R-HSA-373076: Class A/1 (Rhodopsin-like receptors) R-HSA-418594: G alpha (i) signalling events R-HSA-388396: GPCR downstream signaling R-HSA-500792: GPCR ligand binding R-HSA-375276: Peptide ligand-binding receptors R-HSA-162582: Signal Transduction R-HSA-372790: Signaling by GPCR |
Summary | |
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Symbol | CXCR3 |
Name | chemokine (C-X-C motif) receptor 3 |
Aliases | CKR-L2; CMKAR3; IP10-R; MigR; CD183; GPR9; G protein-coupled receptor 9; Mig-R; IP-10 receptor; Mig receptor ...... |
Chromosomal Location | Xq13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between CXCR3 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between CXCR3 and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | CXCR3 |
Name | chemokine (C-X-C motif) receptor 3 |
Aliases | CKR-L2; CMKAR3; IP10-R; MigR; CD183; GPR9; G protein-coupled receptor 9; Mig-R; IP-10 receptor; Mig receptor ...... |
Chromosomal Location | Xq13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of CXCR3 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | CXCR3 |
Name | chemokine (C-X-C motif) receptor 3 |
Aliases | CKR-L2; CMKAR3; IP10-R; MigR; CD183; GPR9; G protein-coupled receptor 9; Mig-R; IP-10 receptor; Mig receptor ...... |
Chromosomal Location | Xq13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of CXCR3 in various data sets.
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Points in the above scatter plot represent the mutation difference of CXCR3 in various data sets.
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Summary | |
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Symbol | CXCR3 |
Name | chemokine (C-X-C motif) receptor 3 |
Aliases | CKR-L2; CMKAR3; IP10-R; MigR; CD183; GPR9; G protein-coupled receptor 9; Mig-R; IP-10 receptor; Mig receptor ...... |
Chromosomal Location | Xq13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of CXCR3. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | CXCR3 |
Name | chemokine (C-X-C motif) receptor 3 |
Aliases | CKR-L2; CMKAR3; IP10-R; MigR; CD183; GPR9; G protein-coupled receptor 9; Mig-R; IP-10 receptor; Mig receptor ...... |
Chromosomal Location | Xq13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of CXCR3. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by CXCR3. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | CXCR3 |
Name | chemokine (C-X-C motif) receptor 3 |
Aliases | CKR-L2; CMKAR3; IP10-R; MigR; CD183; GPR9; G protein-coupled receptor 9; Mig-R; IP-10 receptor; Mig receptor ...... |
Chromosomal Location | Xq13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of CXCR3. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | CXCR3 |
Name | chemokine (C-X-C motif) receptor 3 |
Aliases | CKR-L2; CMKAR3; IP10-R; MigR; CD183; GPR9; G protein-coupled receptor 9; Mig-R; IP-10 receptor; Mig receptor ...... |
Chromosomal Location | Xq13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of CXCR3 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | CXCR3 |
Name | chemokine (C-X-C motif) receptor 3 |
Aliases | CKR-L2; CMKAR3; IP10-R; MigR; CD183; GPR9; G protein-coupled receptor 9; Mig-R; IP-10 receptor; Mig receptor ...... |
Chromosomal Location | Xq13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between CXCR3 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | CXCR3 |
Name | chemokine (C-X-C motif) receptor 3 |
Aliases | CKR-L2; CMKAR3; IP10-R; MigR; CD183; GPR9; G protein-coupled receptor 9; Mig-R; IP-10 receptor; Mig receptor ...... |
Chromosomal Location | Xq13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting CXCR3 collected from DrugBank database. |
There is no record. |