Summary | |
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Symbol | CXCR6 |
Name | chemokine (C-X-C motif) receptor 6 |
Aliases | TYMSTR; STRL33; BONZO; CD186; CDw186; CXC-R6; CXCR-6; G-protein coupled receptor STRL33; G-protein coupled r ...... |
Chromosomal Location | 3p21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cell membrane; Multi-pass membrane protein. |
Domain |
PF00001 7 transmembrane receptor (rhodopsin family) |
Function |
Receptor for the C-X-C chemokine CXCL16. Used as a coreceptor by SIVs and by strains of HIV-2 and m-tropic HIV-1. |
Biological Process |
GO:0019058 viral life cycle GO:0019079 viral genome replication GO:0070098 chemokine-mediated signaling pathway |
Molecular Function |
GO:0001637 G-protein coupled chemoattractant receptor activity GO:0001653 peptide receptor activity GO:0004896 cytokine receptor activity GO:0004950 chemokine receptor activity GO:0008528 G-protein coupled peptide receptor activity GO:0015026 coreceptor activity GO:0016494 C-X-C chemokine receptor activity GO:0019955 cytokine binding GO:0019956 chemokine binding GO:0019958 C-X-C chemokine binding |
Cellular Component | - |
KEGG |
hsa04060 Cytokine-cytokine receptor interaction hsa04062 Chemokine signaling pathway |
Reactome |
R-HSA-380108: Chemokine receptors bind chemokines R-HSA-373076: Class A/1 (Rhodopsin-like receptors) R-HSA-418594: G alpha (i) signalling events R-HSA-388396: GPCR downstream signaling R-HSA-500792: GPCR ligand binding R-HSA-375276: Peptide ligand-binding receptors R-HSA-162582: Signal Transduction R-HSA-372790: Signaling by GPCR |
Summary | |
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Symbol | CXCR6 |
Name | chemokine (C-X-C motif) receptor 6 |
Aliases | TYMSTR; STRL33; BONZO; CD186; CDw186; CXC-R6; CXCR-6; G-protein coupled receptor STRL33; G-protein coupled r ...... |
Chromosomal Location | 3p21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between CXCR6 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | CXCR6 |
Name | chemokine (C-X-C motif) receptor 6 |
Aliases | TYMSTR; STRL33; BONZO; CD186; CDw186; CXC-R6; CXCR-6; G-protein coupled receptor STRL33; G-protein coupled r ...... |
Chromosomal Location | 3p21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of CXCR6 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | CXCR6 |
Name | chemokine (C-X-C motif) receptor 6 |
Aliases | TYMSTR; STRL33; BONZO; CD186; CDw186; CXC-R6; CXCR-6; G-protein coupled receptor STRL33; G-protein coupled r ...... |
Chromosomal Location | 3p21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of CXCR6 in various data sets.
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Points in the above scatter plot represent the mutation difference of CXCR6 in various data sets.
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Summary | |
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Symbol | CXCR6 |
Name | chemokine (C-X-C motif) receptor 6 |
Aliases | TYMSTR; STRL33; BONZO; CD186; CDw186; CXC-R6; CXCR-6; G-protein coupled receptor STRL33; G-protein coupled r ...... |
Chromosomal Location | 3p21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of CXCR6. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | CXCR6 |
Name | chemokine (C-X-C motif) receptor 6 |
Aliases | TYMSTR; STRL33; BONZO; CD186; CDw186; CXC-R6; CXCR-6; G-protein coupled receptor STRL33; G-protein coupled r ...... |
Chromosomal Location | 3p21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of CXCR6. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by CXCR6. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | CXCR6 |
Name | chemokine (C-X-C motif) receptor 6 |
Aliases | TYMSTR; STRL33; BONZO; CD186; CDw186; CXC-R6; CXCR-6; G-protein coupled receptor STRL33; G-protein coupled r ...... |
Chromosomal Location | 3p21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of CXCR6. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | CXCR6 |
Name | chemokine (C-X-C motif) receptor 6 |
Aliases | TYMSTR; STRL33; BONZO; CD186; CDw186; CXC-R6; CXCR-6; G-protein coupled receptor STRL33; G-protein coupled r ...... |
Chromosomal Location | 3p21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of CXCR6 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | CXCR6 |
Name | chemokine (C-X-C motif) receptor 6 |
Aliases | TYMSTR; STRL33; BONZO; CD186; CDw186; CXC-R6; CXCR-6; G-protein coupled receptor STRL33; G-protein coupled r ...... |
Chromosomal Location | 3p21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between CXCR6 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | CXCR6 |
Name | chemokine (C-X-C motif) receptor 6 |
Aliases | TYMSTR; STRL33; BONZO; CD186; CDw186; CXC-R6; CXCR-6; G-protein coupled receptor STRL33; G-protein coupled r ...... |
Chromosomal Location | 3p21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting CXCR6 collected from DrugBank database. |
There is no record. |