Summary | |
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Symbol | CYB5R2 |
Name | cytochrome b5 reductase 2 |
Aliases | B5R.2; cytochrome b5 reductase b5R.2; NADH-cytochrome b5 reductase 2 |
Chromosomal Location | 11p15.4 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | - |
Domain |
PF00970 Oxidoreductase FAD-binding domain PF00175 Oxidoreductase NAD-binding domain |
Function |
NADH-cytochrome b5 reductases are involved in desaturation and elongation of fatty acids, cholesterol biosynthesis, drug metabolism, and, in erythrocyte, methemoglobin reduction (By similarity). Responsible for NADH-dependent lucigenin chemiluminescence in spermatozoa by reducing both lucigenin and 2-[4-iodophenyl]-3-[4-nitrophenyl]-5-[2,4-disulfophenyl]-2H tetrazolium monosodium salt (WST-1). |
Biological Process |
GO:0006694 steroid biosynthetic process GO:0006820 anion transport GO:0008202 steroid metabolic process GO:0015701 bicarbonate transport GO:0015711 organic anion transport GO:0016125 sterol metabolic process GO:0016126 sterol biosynthetic process GO:1901615 organic hydroxy compound metabolic process GO:1901617 organic hydroxy compound biosynthetic process |
Molecular Function |
GO:0004128 cytochrome-b5 reductase activity, acting on NAD(P)H GO:0016651 oxidoreductase activity, acting on NAD(P)H GO:0016653 oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor GO:0048037 cofactor binding GO:0050660 flavin adenine dinucleotide binding GO:0050662 coenzyme binding GO:0071949 FAD binding |
Cellular Component | - |
KEGG |
hsa00520 Amino sugar and nucleotide sugar metabolism |
Reactome |
R-HSA-1237044: Erythrocytes take up carbon dioxide and release oxygen R-HSA-1430728: Metabolism R-HSA-1480926: O2/CO2 exchange in erythrocytes |
Summary | |
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Symbol | CYB5R2 |
Name | cytochrome b5 reductase 2 |
Aliases | B5R.2; cytochrome b5 reductase b5R.2; NADH-cytochrome b5 reductase 2 |
Chromosomal Location | 11p15.4 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between CYB5R2 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | CYB5R2 |
Name | cytochrome b5 reductase 2 |
Aliases | B5R.2; cytochrome b5 reductase b5R.2; NADH-cytochrome b5 reductase 2 |
Chromosomal Location | 11p15.4 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of CYB5R2 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | CYB5R2 |
Name | cytochrome b5 reductase 2 |
Aliases | B5R.2; cytochrome b5 reductase b5R.2; NADH-cytochrome b5 reductase 2 |
Chromosomal Location | 11p15.4 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of CYB5R2 in various data sets.
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Points in the above scatter plot represent the mutation difference of CYB5R2 in various data sets.
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Summary | |
---|---|
Symbol | CYB5R2 |
Name | cytochrome b5 reductase 2 |
Aliases | B5R.2; cytochrome b5 reductase b5R.2; NADH-cytochrome b5 reductase 2 |
Chromosomal Location | 11p15.4 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of CYB5R2. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | CYB5R2 |
Name | cytochrome b5 reductase 2 |
Aliases | B5R.2; cytochrome b5 reductase b5R.2; NADH-cytochrome b5 reductase 2 |
Chromosomal Location | 11p15.4 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of CYB5R2. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by CYB5R2. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | CYB5R2 |
Name | cytochrome b5 reductase 2 |
Aliases | B5R.2; cytochrome b5 reductase b5R.2; NADH-cytochrome b5 reductase 2 |
Chromosomal Location | 11p15.4 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of CYB5R2. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | CYB5R2 |
Name | cytochrome b5 reductase 2 |
Aliases | B5R.2; cytochrome b5 reductase b5R.2; NADH-cytochrome b5 reductase 2 |
Chromosomal Location | 11p15.4 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of CYB5R2 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | CYB5R2 |
Name | cytochrome b5 reductase 2 |
Aliases | B5R.2; cytochrome b5 reductase b5R.2; NADH-cytochrome b5 reductase 2 |
Chromosomal Location | 11p15.4 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between CYB5R2 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |