Summary | |
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Symbol | CYP2A7 |
Name | cytochrome P450, family 2, subfamily A, polypeptide 7 |
Aliases | cytochrome P450, subfamily IIA (phenobarbital-inducible), polypeptide 7; CPA7; CYPIIA7; P450-IIA4; cytochrom ...... |
Chromosomal Location | 19q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein. |
Domain |
PF00067 Cytochrome P450 |
Function |
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. |
Biological Process |
GO:0001676 long-chain fatty acid metabolic process GO:0006631 fatty acid metabolic process GO:0006690 icosanoid metabolic process GO:0019369 arachidonic acid metabolic process GO:0019373 epoxygenase P450 pathway GO:0033559 unsaturated fatty acid metabolic process |
Molecular Function |
GO:0004497 monooxygenase activity GO:0005506 iron ion binding GO:0008391 arachidonic acid monooxygenase activity GO:0008392 arachidonic acid epoxygenase activity GO:0008395 steroid hydroxylase activity GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen GO:0019825 oxygen binding GO:0020037 heme binding GO:0046906 tetrapyrrole binding GO:0070330 aromatase activity |
Cellular Component | - |
KEGG | - |
Reactome |
R-HSA-211859: Biological oxidations R-HSA-211999: CYP2E1 reactions R-HSA-211897: Cytochrome P450 - arranged by substrate type R-HSA-211935: Fatty acids R-HSA-1430728: Metabolism R-HSA-211945: Phase 1 - Functionalization of compounds R-HSA-211981: Xenobiotics |
Summary | |
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Symbol | CYP2A7 |
Name | cytochrome P450, family 2, subfamily A, polypeptide 7 |
Aliases | cytochrome P450, subfamily IIA (phenobarbital-inducible), polypeptide 7; CPA7; CYPIIA7; P450-IIA4; cytochrom ...... |
Chromosomal Location | 19q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between CYP2A7 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | CYP2A7 |
Name | cytochrome P450, family 2, subfamily A, polypeptide 7 |
Aliases | cytochrome P450, subfamily IIA (phenobarbital-inducible), polypeptide 7; CPA7; CYPIIA7; P450-IIA4; cytochrom ...... |
Chromosomal Location | 19q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of CYP2A7 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | CYP2A7 |
Name | cytochrome P450, family 2, subfamily A, polypeptide 7 |
Aliases | cytochrome P450, subfamily IIA (phenobarbital-inducible), polypeptide 7; CPA7; CYPIIA7; P450-IIA4; cytochrom ...... |
Chromosomal Location | 19q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of CYP2A7 in various data sets.
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Points in the above scatter plot represent the mutation difference of CYP2A7 in various data sets.
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Summary | |
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Symbol | CYP2A7 |
Name | cytochrome P450, family 2, subfamily A, polypeptide 7 |
Aliases | cytochrome P450, subfamily IIA (phenobarbital-inducible), polypeptide 7; CPA7; CYPIIA7; P450-IIA4; cytochrom ...... |
Chromosomal Location | 19q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of CYP2A7. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | CYP2A7 |
Name | cytochrome P450, family 2, subfamily A, polypeptide 7 |
Aliases | cytochrome P450, subfamily IIA (phenobarbital-inducible), polypeptide 7; CPA7; CYPIIA7; P450-IIA4; cytochrom ...... |
Chromosomal Location | 19q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of CYP2A7. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by CYP2A7. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | CYP2A7 |
Name | cytochrome P450, family 2, subfamily A, polypeptide 7 |
Aliases | cytochrome P450, subfamily IIA (phenobarbital-inducible), polypeptide 7; CPA7; CYPIIA7; P450-IIA4; cytochrom ...... |
Chromosomal Location | 19q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of CYP2A7. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | CYP2A7 |
Name | cytochrome P450, family 2, subfamily A, polypeptide 7 |
Aliases | cytochrome P450, subfamily IIA (phenobarbital-inducible), polypeptide 7; CPA7; CYPIIA7; P450-IIA4; cytochrom ...... |
Chromosomal Location | 19q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of CYP2A7 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | CYP2A7 |
Name | cytochrome P450, family 2, subfamily A, polypeptide 7 |
Aliases | cytochrome P450, subfamily IIA (phenobarbital-inducible), polypeptide 7; CPA7; CYPIIA7; P450-IIA4; cytochrom ...... |
Chromosomal Location | 19q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between CYP2A7 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | CYP2A7 |
Name | cytochrome P450, family 2, subfamily A, polypeptide 7 |
Aliases | cytochrome P450, subfamily IIA (phenobarbital-inducible), polypeptide 7; CPA7; CYPIIA7; P450-IIA4; cytochrom ...... |
Chromosomal Location | 19q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting CYP2A7 collected from DrugBank database. |
There is no record. |