Summary | |
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Symbol | CYP39A1 |
Name | cytochrome P450, family 39, subfamily A, polypeptide 1 |
Aliases | cytochrome P450, subfamily XXXIX (oxysterol 7 alpha-hydroxylase), polypeptide 1; hCYP39A1; Cytochrome P450 3 ...... |
Chromosomal Location | 6p12.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein. |
Domain |
PF00067 Cytochrome P450 |
Function |
Involved in the bile acid metabolism. Has a preference for 24-hydroxycholesterol, and converts it into a 7-alpha-hydroxylated product. |
Biological Process |
GO:0006066 alcohol metabolic process GO:0006694 steroid biosynthetic process GO:0006699 bile acid biosynthetic process GO:0006706 steroid catabolic process GO:0006707 cholesterol catabolic process GO:0007586 digestion GO:0008202 steroid metabolic process GO:0008203 cholesterol metabolic process GO:0008206 bile acid metabolic process GO:0016042 lipid catabolic process GO:0016053 organic acid biosynthetic process GO:0016054 organic acid catabolic process GO:0016125 sterol metabolic process GO:0016127 sterol catabolic process GO:0030573 bile acid catabolic process GO:0044282 small molecule catabolic process GO:0044283 small molecule biosynthetic process GO:0046164 alcohol catabolic process GO:0046394 carboxylic acid biosynthetic process GO:0046395 carboxylic acid catabolic process GO:0072329 monocarboxylic acid catabolic process GO:0072330 monocarboxylic acid biosynthetic process GO:1901361 organic cyclic compound catabolic process GO:1901615 organic hydroxy compound metabolic process GO:1901616 organic hydroxy compound catabolic process GO:1902652 secondary alcohol metabolic process |
Molecular Function |
GO:0004497 monooxygenase activity GO:0005506 iron ion binding GO:0008387 steroid 7-alpha-hydroxylase activity GO:0008395 steroid hydroxylase activity GO:0008396 oxysterol 7-alpha-hydroxylase activity GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen GO:0020037 heme binding GO:0046906 tetrapyrrole binding |
Cellular Component | - |
KEGG |
hsa00120 Primary bile acid biosynthesis |
Reactome |
R-HSA-194068: Bile acid and bile salt metabolism R-HSA-211859: Biological oxidations R-HSA-211897: Cytochrome P450 - arranged by substrate type R-HSA-211976: Endogenous sterols R-HSA-1430728: Metabolism R-HSA-556833: Metabolism of lipids and lipoproteins R-HSA-211945: Phase 1 - Functionalization of compounds R-HSA-192105: Synthesis of bile acids and bile salts R-HSA-193775: Synthesis of bile acids and bile salts via 24-hydroxycholesterol |
Summary | |
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Symbol | CYP39A1 |
Name | cytochrome P450, family 39, subfamily A, polypeptide 1 |
Aliases | cytochrome P450, subfamily XXXIX (oxysterol 7 alpha-hydroxylase), polypeptide 1; hCYP39A1; Cytochrome P450 3 ...... |
Chromosomal Location | 6p12.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between CYP39A1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | CYP39A1 |
Name | cytochrome P450, family 39, subfamily A, polypeptide 1 |
Aliases | cytochrome P450, subfamily XXXIX (oxysterol 7 alpha-hydroxylase), polypeptide 1; hCYP39A1; Cytochrome P450 3 ...... |
Chromosomal Location | 6p12.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of CYP39A1 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | CYP39A1 |
Name | cytochrome P450, family 39, subfamily A, polypeptide 1 |
Aliases | cytochrome P450, subfamily XXXIX (oxysterol 7 alpha-hydroxylase), polypeptide 1; hCYP39A1; Cytochrome P450 3 ...... |
Chromosomal Location | 6p12.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of CYP39A1 in various data sets.
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Points in the above scatter plot represent the mutation difference of CYP39A1 in various data sets.
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Summary | |
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Symbol | CYP39A1 |
Name | cytochrome P450, family 39, subfamily A, polypeptide 1 |
Aliases | cytochrome P450, subfamily XXXIX (oxysterol 7 alpha-hydroxylase), polypeptide 1; hCYP39A1; Cytochrome P450 3 ...... |
Chromosomal Location | 6p12.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of CYP39A1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | CYP39A1 |
Name | cytochrome P450, family 39, subfamily A, polypeptide 1 |
Aliases | cytochrome P450, subfamily XXXIX (oxysterol 7 alpha-hydroxylase), polypeptide 1; hCYP39A1; Cytochrome P450 3 ...... |
Chromosomal Location | 6p12.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of CYP39A1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by CYP39A1. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | CYP39A1 |
Name | cytochrome P450, family 39, subfamily A, polypeptide 1 |
Aliases | cytochrome P450, subfamily XXXIX (oxysterol 7 alpha-hydroxylase), polypeptide 1; hCYP39A1; Cytochrome P450 3 ...... |
Chromosomal Location | 6p12.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of CYP39A1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | CYP39A1 |
Name | cytochrome P450, family 39, subfamily A, polypeptide 1 |
Aliases | cytochrome P450, subfamily XXXIX (oxysterol 7 alpha-hydroxylase), polypeptide 1; hCYP39A1; Cytochrome P450 3 ...... |
Chromosomal Location | 6p12.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of CYP39A1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | CYP39A1 |
Name | cytochrome P450, family 39, subfamily A, polypeptide 1 |
Aliases | cytochrome P450, subfamily XXXIX (oxysterol 7 alpha-hydroxylase), polypeptide 1; hCYP39A1; Cytochrome P450 3 ...... |
Chromosomal Location | 6p12.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between CYP39A1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | CYP39A1 |
Name | cytochrome P450, family 39, subfamily A, polypeptide 1 |
Aliases | cytochrome P450, subfamily XXXIX (oxysterol 7 alpha-hydroxylase), polypeptide 1; hCYP39A1; Cytochrome P450 3 ...... |
Chromosomal Location | 6p12.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting CYP39A1 collected from DrugBank database. |
There is no record. |