Summary | |
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Symbol | DACT1 |
Name | dishevelled-binding antagonist of beta-catenin 1 |
Aliases | DAPPER1; THYEX3; HDPR1; DAPPER; FRODO; dapper homolog 1, antagonist of beta-catenin (xenopus); dapper, antag ...... |
Chromosomal Location | 14q22.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cytoplasm. Nucleus. Cell junction, synapse Note=Shuttles between the nucleus and the cytoplasm. Seems to be nuclear in the absence of Wnt signaling and to translocate to the cytoplasm in its presence. |
Domain |
PF15268 Dapper |
Function |
Involved in regulation of intracellular signaling pathways during development. Specifically thought to play a role in canonical and/or non-canonical Wnt signaling pathways through interaction with DSH (Dishevelled) family proteins. The activation/inhibition of Wnt signaling may depend on the phosphorylation status. Proposed to regulate the degradation of CTNNB1/beta-catenin, thereby modulating the transcriptional activation of target genes of the Wnt signaling pathway. Its function in stabilizing CTNNB1 may involve inhibition of GSK3B activity. Promotes the membrane localization of CTNNB1. The cytoplasmic form can induce DVL2 degradation via a lysosome-dependent mechanism; the function is inhibited by PKA-induced binding to 14-3-3 proteins, such as YWHAB. Seems to be involved in morphogenesis at the primitive streak by regulating VANGL2 and DVL2; the function seems to be independent of canonical Wnt signaling and rather involves the non-canonical Wnt/planar cell polarity (PCP) pathway (By similarity). The nuclear form may prevent the formation of LEF1:CTNNB1 complex and recruit HDAC1 to LEF1 at target gene promoters to repress transcription thus antagonizing Wnt signaling. May be involved in positive regulation of fat cell differentiation. During neuronal differentiation may be involved in excitatory synapse organization, and dendrite formation and establishment of spines. |
Biological Process |
GO:0000082 G1/S transition of mitotic cell cycle GO:0001736 establishment of planar polarity GO:0001738 morphogenesis of a polarized epithelium GO:0001933 negative regulation of protein phosphorylation GO:0006606 protein import into nucleus GO:0006913 nucleocytoplasmic transport GO:0007164 establishment of tissue polarity GO:0007254 JNK cascade GO:0007346 regulation of mitotic cell cycle GO:0007442 hindgut morphogenesis GO:0009894 regulation of catabolic process GO:0009896 positive regulation of catabolic process GO:0010948 negative regulation of cell cycle process GO:0016055 Wnt signaling pathway GO:0017038 protein import GO:0021915 neural tube development GO:0030111 regulation of Wnt signaling pathway GO:0030177 positive regulation of Wnt signaling pathway GO:0030178 negative regulation of Wnt signaling pathway GO:0031098 stress-activated protein kinase signaling cascade GO:0031329 regulation of cellular catabolic process GO:0031331 positive regulation of cellular catabolic process GO:0031333 negative regulation of protein complex assembly GO:0031647 regulation of protein stability GO:0032091 negative regulation of protein binding GO:0032092 positive regulation of protein binding GO:0032386 regulation of intracellular transport GO:0032388 positive regulation of intracellular transport GO:0032872 regulation of stress-activated MAPK cascade GO:0032873 negative regulation of stress-activated MAPK cascade GO:0033157 regulation of intracellular protein transport GO:0034504 protein localization to nucleus GO:0035239 tube morphogenesis GO:0035411 catenin import into nucleus GO:0035412 regulation of catenin import into nucleus GO:0035413 positive regulation of catenin import into nucleus GO:0035567 non-canonical Wnt signaling pathway GO:0042176 regulation of protein catabolic process GO:0042306 regulation of protein import into nucleus GO:0042307 positive regulation of protein import into nucleus GO:0042326 negative regulation of phosphorylation GO:0043254 regulation of protein complex assembly GO:0043393 regulation of protein binding GO:0043409 negative regulation of MAPK cascade GO:0044744 protein targeting to nucleus GO:0044770 cell cycle phase transition GO:0044772 mitotic cell cycle phase transition GO:0044843 cell cycle G1/S phase transition GO:0045732 positive regulation of protein catabolic process GO:0045786 negative regulation of cell cycle GO:0045930 negative regulation of mitotic cell cycle GO:0046328 regulation of JNK cascade GO:0046329 negative regulation of JNK cascade GO:0046822 regulation of nucleocytoplasmic transport GO:0046824 positive regulation of nucleocytoplasmic transport GO:0048546 digestive tract morphogenesis GO:0048565 digestive tract development GO:0048619 embryonic hindgut morphogenesis GO:0051098 regulation of binding GO:0051099 positive regulation of binding GO:0051100 negative regulation of binding GO:0051169 nuclear transport GO:0051170 nuclear import GO:0051222 positive regulation of protein transport GO:0051403 stress-activated MAPK cascade GO:0055123 digestive system development GO:0060070 canonical Wnt signaling pathway GO:0060071 Wnt signaling pathway, planar cell polarity pathway GO:0060828 regulation of canonical Wnt signaling pathway GO:0061525 hindgut development GO:0070302 regulation of stress-activated protein kinase signaling cascade GO:0070303 negative regulation of stress-activated protein kinase signaling cascade GO:0090090 negative regulation of canonical Wnt signaling pathway GO:0090175 regulation of establishment of planar polarity GO:0090316 positive regulation of intracellular protein transport GO:0198738 cell-cell signaling by wnt GO:1900180 regulation of protein localization to nucleus GO:1900182 positive regulation of protein localization to nucleus GO:1901987 regulation of cell cycle phase transition GO:1901988 negative regulation of cell cycle phase transition GO:1901990 regulation of mitotic cell cycle phase transition GO:1901991 negative regulation of mitotic cell cycle phase transition GO:1902532 negative regulation of intracellular signal transduction GO:1902593 single-organism nuclear import GO:1902806 regulation of cell cycle G1/S phase transition GO:1902807 negative regulation of cell cycle G1/S phase transition GO:1903362 regulation of cellular protein catabolic process GO:1903364 positive regulation of cellular protein catabolic process GO:1903533 regulation of protein targeting GO:1903829 positive regulation of cellular protein localization GO:1904589 regulation of protein import GO:1904591 positive regulation of protein import GO:1904837 beta-catenin-TCF complex assembly GO:1904863 regulation of beta-catenin-TCF complex assembly GO:1904864 negative regulation of beta-catenin-TCF complex assembly GO:1904951 positive regulation of establishment of protein localization GO:1905330 regulation of morphogenesis of an epithelium GO:2000027 regulation of organ morphogenesis GO:2000045 regulation of G1/S transition of mitotic cell cycle GO:2000050 regulation of non-canonical Wnt signaling pathway GO:2000095 regulation of Wnt signaling pathway, planar cell polarity pathway GO:2000134 negative regulation of G1/S transition of mitotic cell cycle |
Molecular Function |
GO:0001085 RNA polymerase II transcription factor binding GO:0005080 protein kinase C binding GO:0008013 beta-catenin binding GO:0008134 transcription factor binding GO:0042826 histone deacetylase binding GO:0051018 protein kinase A binding GO:0070097 delta-catenin binding |
Cellular Component |
GO:0030877 beta-catenin destruction complex |
KEGG | - |
Reactome |
R-HSA-4641258: Degradation of DVL R-HSA-162582: Signal Transduction R-HSA-195721: Signaling by Wnt R-HSA-201681: TCF dependent signaling in response to WNT |
Summary | |
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Symbol | DACT1 |
Name | dishevelled-binding antagonist of beta-catenin 1 |
Aliases | DAPPER1; THYEX3; HDPR1; DAPPER; FRODO; dapper homolog 1, antagonist of beta-catenin (xenopus); dapper, antag ...... |
Chromosomal Location | 14q22.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between DACT1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | DACT1 |
Name | dishevelled-binding antagonist of beta-catenin 1 |
Aliases | DAPPER1; THYEX3; HDPR1; DAPPER; FRODO; dapper homolog 1, antagonist of beta-catenin (xenopus); dapper, antag ...... |
Chromosomal Location | 14q22.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of DACT1 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | DACT1 |
Name | dishevelled-binding antagonist of beta-catenin 1 |
Aliases | DAPPER1; THYEX3; HDPR1; DAPPER; FRODO; dapper homolog 1, antagonist of beta-catenin (xenopus); dapper, antag ...... |
Chromosomal Location | 14q22.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of DACT1 in various data sets.
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Points in the above scatter plot represent the mutation difference of DACT1 in various data sets.
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Summary | |
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Symbol | DACT1 |
Name | dishevelled-binding antagonist of beta-catenin 1 |
Aliases | DAPPER1; THYEX3; HDPR1; DAPPER; FRODO; dapper homolog 1, antagonist of beta-catenin (xenopus); dapper, antag ...... |
Chromosomal Location | 14q22.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of DACT1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | DACT1 |
Name | dishevelled-binding antagonist of beta-catenin 1 |
Aliases | DAPPER1; THYEX3; HDPR1; DAPPER; FRODO; dapper homolog 1, antagonist of beta-catenin (xenopus); dapper, antag ...... |
Chromosomal Location | 14q22.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of DACT1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by DACT1. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | DACT1 |
Name | dishevelled-binding antagonist of beta-catenin 1 |
Aliases | DAPPER1; THYEX3; HDPR1; DAPPER; FRODO; dapper homolog 1, antagonist of beta-catenin (xenopus); dapper, antag ...... |
Chromosomal Location | 14q22.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of DACT1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | DACT1 |
Name | dishevelled-binding antagonist of beta-catenin 1 |
Aliases | DAPPER1; THYEX3; HDPR1; DAPPER; FRODO; dapper homolog 1, antagonist of beta-catenin (xenopus); dapper, antag ...... |
Chromosomal Location | 14q22.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of DACT1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | DACT1 |
Name | dishevelled-binding antagonist of beta-catenin 1 |
Aliases | DAPPER1; THYEX3; HDPR1; DAPPER; FRODO; dapper homolog 1, antagonist of beta-catenin (xenopus); dapper, antag ...... |
Chromosomal Location | 14q22.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between DACT1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | DACT1 |
Name | dishevelled-binding antagonist of beta-catenin 1 |
Aliases | DAPPER1; THYEX3; HDPR1; DAPPER; FRODO; dapper homolog 1, antagonist of beta-catenin (xenopus); dapper, antag ...... |
Chromosomal Location | 14q22.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting DACT1 collected from DrugBank database. |
There is no record. |