TISIDB

Summary
Symbol	DACT2
Name	dishevelled-binding antagonist of beta-catenin 2
Aliases	bA503C24.7; DAPPER2; C6orf116; chromosome 6 open reading frame 116; dapper homolog 2, antagonist of beta-cat ......
Chromosomal Location	6q27
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway

> Subcellular Location, Domain and Function [ TOP ]
Subcellular Location	-
Domain	PF15268 Dapper
Function	Involved in regulation of intracellular signaling pathways during development. Negatively regulates the Nodal signaling pathway, possibly by promoting the lysosomal degradation of Nodal receptors, such as TGFBR1. May be involved in control of the morphogenetic behavior of kidney ureteric bud cells by keeping cells epithelial and restraining their mesenchymal character. May play an inhibitory role in the re-epithelialization of skin wounds by attenuating TGF-beta signaling (By similarity).

> Gene Ontology [ TOP ]
Biological Process	GO:0001655 urogenital system development GO:0001822 kidney development GO:0002064 epithelial cell development GO:0002244 hematopoietic progenitor cell differentiation GO:0003382 epithelial cell morphogenesis GO:0007162 negative regulation of cell adhesion GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway GO:0016055 Wnt signaling pathway GO:0030111 regulation of Wnt signaling pathway GO:0032924 activin receptor signaling pathway GO:0032925 regulation of activin receptor signaling pathway GO:0032926 negative regulation of activin receptor signaling pathway GO:0038092 nodal signaling pathway GO:0043588 skin development GO:0072001 renal system development GO:0072044 collecting duct development GO:0072061 inner medullary collecting duct development GO:0090092 regulation of transmembrane receptor protein serine/threonine kinase signaling pathway GO:0090101 negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway GO:0198738 cell-cell signaling by wnt GO:1900107 regulation of nodal signaling pathway GO:1900108 negative regulation of nodal signaling pathway
Molecular Function	GO:0005080 protein kinase C binding GO:0008013 beta-catenin binding GO:0008134 transcription factor binding GO:0051018 protein kinase A binding GO:0070097 delta-catenin binding
Cellular Component	-

> KEGG and Reactome Pathway [ TOP ]
KEGG	-
Reactome	-

Summary
Symbol	DACT2
Name	dishevelled-binding antagonist of beta-catenin 2
Aliases	bA503C24.7; DAPPER2; C6orf116; chromosome 6 open reading frame 116; dapper homolog 2, antagonist of beta-cat ......
Chromosomal Location	6q27
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Literatures that report relations between DACT2 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.

> Text Mining [ TOP ]
There is no record.

Summary
Symbol	DACT2
Name	dishevelled-binding antagonist of beta-catenin 2
Aliases	bA503C24.7; DAPPER2; C6orf116; chromosome 6 open reading frame 116; dapper homolog 2, antagonist of beta-cat ......
Chromosomal Location	6q27
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.

> High-throughput Screening

[ TOP ]

Statistical results of DACT2 in screening data sets for detecting immune reponses.

PMID	Screening System	Cancer Type	Cell Line	Data Set	Statistical Results	Relation to immunity
29301958	CRISPR-Cas9	melanoma	B16F10	Pmel-1 T cell	NA/NS	NA/NS
29301958	CRISPR-Cas9	melanoma	B16F10	OT-1 T cell	NA/NS	NA/NS
28783722	CRISPR-Cas9	melanoma	Mel624	2CT-CRISPR	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX+Anti-PD1	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX	NA/NS	NA/NS
25691366	RNAi	Breast cancer	MCF7	Luc-CTL assay	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Primary screen	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Secondary screen	NA/NS	NA/NS

Summary
Symbol	DACT2
Name	dishevelled-binding antagonist of beta-catenin 2
Aliases	bA503C24.7; DAPPER2; C6orf116; chromosome 6 open reading frame 116; dapper homolog 2, antagonist of beta-cat ......
Chromosomal Location	6q27
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders

> Expression difference between responders and non-responders

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Points in the above scatter plot represent the expression difference of DACT2 in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	Log2 (Fold Change)	P value
1	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	14	12	0.683	0.0753
2	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	6	5	0.367	0.575
3	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	7	0.92	0.1
4	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	1.967	0.0118
5	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	1.967	0.087
6	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	1.988	0.185
7	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	26	23	0.595	0.451
8	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	15	11	0.96	0.45
9	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	11	12	0.13	0.921
10	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	4	8	-0.89	0.17
11	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	2	0	0	1
12	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	2	8	-0.89	0.317
13	29443960	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	68	230	-0.317	0.276

> Mutation difference between responders and non-responders

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Points in the above scatter plot represent the mutation difference of DACT2 in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	% Mut/Res	% Mut/NRes	% Diff (R vs NR)	Pval
1	25765070	Non-small cell lung cancer (NSCLC)	all	Anti-PD-1 (pembrolizumab)	14	17	0	0	0	1
2	25765070	Non-small cell lung cancer (NSCLC)	smoking	Anti-PD-1 (pembrolizumab)	10	3	0	0	0	1
3	25765070	Non-small cell lung cancer (NSCLC)	non-smoking	Anti-PD-1 (pembrolizumab)	4	14	0	0	0	1
4	26359337	Melanoma	all	Anti-CTLA-4 (ipilimumab)	27	73	0	0	0	1
5	26359337	Melanoma	BRAFi	Anti-CTLA-4 (ipilimumab)	0	14	0	0	0	1
6	26359337	Melanoma	non-BRAFi	Anti-CTLA-4 (ipilimumab)	27	59	0	0	0	1
7	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	21	17	23.8	5.9	17.9	0.197
8	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	6	12.5	0	12.5	1
9	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	13	11	30.8	9.1	21.7	0.327
10	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	0	0	0	1
11	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	0	0	0	1
12	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	0	0	0	1
13	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	38	27	10.5	7.4	3.1	1
14	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	22	13	9.1	15.4	-6.3	0.618
15	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	16	14	12.5	0	12.5	0.485
16	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	11	13	0	0	0	1
17	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	6	1	0	0	0	1
18	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	5	12	0	0	0	1

Summary
Symbol	DACT2
Name	dishevelled-binding antagonist of beta-catenin 2
Aliases	bA503C24.7; DAPPER2; C6orf116; chromosome 6 open reading frame 116; dapper homolog 2, antagonist of beta-cat ......
Chromosomal Location	6q27
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of DACT2. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.

> Lymphocyte [ TOP ]

Summary
Symbol	DACT2
Name	dishevelled-binding antagonist of beta-catenin 2
Aliases	bA503C24.7; DAPPER2; C6orf116; chromosome 6 open reading frame 116; dapper homolog 2, antagonist of beta-cat ......
Chromosomal Location	6q27
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of DACT2. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by DACT2. > Immunoinhibitor > Immunostimulator > MHC molecule

> Immunoinhibitor [ TOP ]

> Immunostimulator [ TOP ]

> MHC molecule [ TOP ]

Summary
Symbol	DACT2
Name	dishevelled-binding antagonist of beta-catenin 2
Aliases	bA503C24.7; DAPPER2; C6orf116; chromosome 6 open reading frame 116; dapper homolog 2, antagonist of beta-cat ......
Chromosomal Location	6q27
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of DACT2. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor

> Chemokine [ TOP ]

> Receptor [ TOP ]

Summary
Symbol	DACT2
Name	dishevelled-binding antagonist of beta-catenin 2
Aliases	bA503C24.7; DAPPER2; C6orf116; chromosome 6 open reading frame 116; dapper homolog 2, antagonist of beta-cat ......
Chromosomal Location	6q27
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Distribution of DACT2 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype

> Immune subtype [ TOP ]

> Molecular subtype [ TOP ]

Summary
Symbol	DACT2
Name	dishevelled-binding antagonist of beta-catenin 2
Aliases	bA503C24.7; DAPPER2; C6orf116; chromosome 6 open reading frame 116; dapper homolog 2, antagonist of beta-cat ......
Chromosomal Location	6q27
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Associations between DACT2 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade

> Overall survival [ TOP ]

> Stage [ TOP ]

> Grade [ TOP ]

Summary
Symbol	DACT2
Name	dishevelled-binding antagonist of beta-catenin 2
Aliases	bA503C24.7; DAPPER2; C6orf116; chromosome 6 open reading frame 116; dapper homolog 2, antagonist of beta-cat ......
Chromosomal Location	6q27
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Drugs targeting DACT2 collected from DrugBank database.

> Drugs from DrugBank database [ TOP ]
There is no record.

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