Summary | |
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Symbol | DACT3 |
Name | dishevelled-binding antagonist of beta-catenin 3 |
Aliases | MGC15476; DAPPER3; RRR1; arginine rich region 1; dapper, antagonist of beta-catenin, homolog 3 (Xenopus laev ...... |
Chromosomal Location | 19q13.32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | - |
Domain |
PF15268 Dapper |
Function |
May be involved in regulation of intracellular signaling pathways during development. Specifically thought to play a role in canonical and/or non-canonical Wnt signaling pathways through interaction with DSH (Dishevelled) family proteins. |
Biological Process |
GO:0001558 regulation of cell growth GO:0001837 epithelial to mesenchymal transition GO:0006606 protein import into nucleus GO:0006913 nucleocytoplasmic transport GO:0010717 regulation of epithelial to mesenchymal transition GO:0010719 negative regulation of epithelial to mesenchymal transition GO:0016049 cell growth GO:0016055 Wnt signaling pathway GO:0017038 protein import GO:0030111 regulation of Wnt signaling pathway GO:0030178 negative regulation of Wnt signaling pathway GO:0030308 negative regulation of cell growth GO:0032386 regulation of intracellular transport GO:0032387 negative regulation of intracellular transport GO:0033157 regulation of intracellular protein transport GO:0034504 protein localization to nucleus GO:0035411 catenin import into nucleus GO:0035412 regulation of catenin import into nucleus GO:0035414 negative regulation of catenin import into nucleus GO:0042306 regulation of protein import into nucleus GO:0042308 negative regulation of protein import into nucleus GO:0044744 protein targeting to nucleus GO:0045926 negative regulation of growth GO:0046822 regulation of nucleocytoplasmic transport GO:0046823 negative regulation of nucleocytoplasmic transport GO:0048762 mesenchymal cell differentiation GO:0051051 negative regulation of transport GO:0051169 nuclear transport GO:0051170 nuclear import GO:0051224 negative regulation of protein transport GO:0060070 canonical Wnt signaling pathway GO:0060485 mesenchyme development GO:0060828 regulation of canonical Wnt signaling pathway GO:0090090 negative regulation of canonical Wnt signaling pathway GO:0090317 negative regulation of intracellular protein transport GO:0198738 cell-cell signaling by wnt GO:1900180 regulation of protein localization to nucleus GO:1900181 negative regulation of protein localization to nucleus GO:1902593 single-organism nuclear import GO:1903533 regulation of protein targeting GO:1903828 negative regulation of cellular protein localization GO:1904589 regulation of protein import GO:1904590 negative regulation of protein import GO:1904950 negative regulation of establishment of protein localization |
Molecular Function |
GO:0005080 protein kinase C binding GO:0008013 beta-catenin binding GO:0051018 protein kinase A binding GO:0070097 delta-catenin binding |
Cellular Component | - |
KEGG | - |
Reactome | - |
Summary | |
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Symbol | DACT3 |
Name | dishevelled-binding antagonist of beta-catenin 3 |
Aliases | MGC15476; DAPPER3; RRR1; arginine rich region 1; dapper, antagonist of beta-catenin, homolog 3 (Xenopus laev ...... |
Chromosomal Location | 19q13.32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between DACT3 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | DACT3 |
Name | dishevelled-binding antagonist of beta-catenin 3 |
Aliases | MGC15476; DAPPER3; RRR1; arginine rich region 1; dapper, antagonist of beta-catenin, homolog 3 (Xenopus laev ...... |
Chromosomal Location | 19q13.32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of DACT3 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | DACT3 |
Name | dishevelled-binding antagonist of beta-catenin 3 |
Aliases | MGC15476; DAPPER3; RRR1; arginine rich region 1; dapper, antagonist of beta-catenin, homolog 3 (Xenopus laev ...... |
Chromosomal Location | 19q13.32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of DACT3 in various data sets.
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Points in the above scatter plot represent the mutation difference of DACT3 in various data sets.
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Summary | |
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Symbol | DACT3 |
Name | dishevelled-binding antagonist of beta-catenin 3 |
Aliases | MGC15476; DAPPER3; RRR1; arginine rich region 1; dapper, antagonist of beta-catenin, homolog 3 (Xenopus laev ...... |
Chromosomal Location | 19q13.32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of DACT3. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | DACT3 |
Name | dishevelled-binding antagonist of beta-catenin 3 |
Aliases | MGC15476; DAPPER3; RRR1; arginine rich region 1; dapper, antagonist of beta-catenin, homolog 3 (Xenopus laev ...... |
Chromosomal Location | 19q13.32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of DACT3. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by DACT3. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | DACT3 |
Name | dishevelled-binding antagonist of beta-catenin 3 |
Aliases | MGC15476; DAPPER3; RRR1; arginine rich region 1; dapper, antagonist of beta-catenin, homolog 3 (Xenopus laev ...... |
Chromosomal Location | 19q13.32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of DACT3. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | DACT3 |
Name | dishevelled-binding antagonist of beta-catenin 3 |
Aliases | MGC15476; DAPPER3; RRR1; arginine rich region 1; dapper, antagonist of beta-catenin, homolog 3 (Xenopus laev ...... |
Chromosomal Location | 19q13.32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of DACT3 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | DACT3 |
Name | dishevelled-binding antagonist of beta-catenin 3 |
Aliases | MGC15476; DAPPER3; RRR1; arginine rich region 1; dapper, antagonist of beta-catenin, homolog 3 (Xenopus laev ...... |
Chromosomal Location | 19q13.32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between DACT3 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | DACT3 |
Name | dishevelled-binding antagonist of beta-catenin 3 |
Aliases | MGC15476; DAPPER3; RRR1; arginine rich region 1; dapper, antagonist of beta-catenin, homolog 3 (Xenopus laev ...... |
Chromosomal Location | 19q13.32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting DACT3 collected from DrugBank database. |
There is no record. |