Summary | |
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Symbol | DBP |
Name | D site of albumin promoter (albumin D-box) binding protein |
Aliases | DABP; albumin D box-binding protein; albumin D-element-binding protein; tax-responsive enhancer element-bind ...... |
Chromosomal Location | 19q13.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Nucleus. |
Domain |
PF07716 Basic region leucine zipper |
Function |
This transcriptional activator recognizes and binds to the sequence 5'-RTTAYGTAAY-3' found in the promoter of genes such as albumin, CYP2A4 and CYP2A5. It is not essential for circadian rhythm generation, but modulates important clock output genes. May be a direct target for regulation by the circadian pacemaker component clock. May affect circadian period and sleep regulation. |
Biological Process |
GO:0001889 liver development GO:0007623 circadian rhythm GO:0048511 rhythmic process GO:0048732 gland development GO:0061008 hepaticobiliary system development |
Molecular Function |
GO:0000982 transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding |
Cellular Component | - |
KEGG | - |
Reactome |
R-HSA-1368108: BMAL1 R-HSA-400253: Circadian Clock |
Summary | |
---|---|
Symbol | DBP |
Name | D site of albumin promoter (albumin D-box) binding protein |
Aliases | DABP; albumin D box-binding protein; albumin D-element-binding protein; tax-responsive enhancer element-bind ...... |
Chromosomal Location | 19q13.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between DBP and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | DBP |
Name | D site of albumin promoter (albumin D-box) binding protein |
Aliases | DABP; albumin D box-binding protein; albumin D-element-binding protein; tax-responsive enhancer element-bind ...... |
Chromosomal Location | 19q13.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of DBP in screening data sets for detecting immune reponses.
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Summary | |
---|---|
Symbol | DBP |
Name | D site of albumin promoter (albumin D-box) binding protein |
Aliases | DABP; albumin D box-binding protein; albumin D-element-binding protein; tax-responsive enhancer element-bind ...... |
Chromosomal Location | 19q13.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of DBP in various data sets.
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Points in the above scatter plot represent the mutation difference of DBP in various data sets.
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Summary | |
---|---|
Symbol | DBP |
Name | D site of albumin promoter (albumin D-box) binding protein |
Aliases | DABP; albumin D box-binding protein; albumin D-element-binding protein; tax-responsive enhancer element-bind ...... |
Chromosomal Location | 19q13.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of DBP. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | DBP |
Name | D site of albumin promoter (albumin D-box) binding protein |
Aliases | DABP; albumin D box-binding protein; albumin D-element-binding protein; tax-responsive enhancer element-bind ...... |
Chromosomal Location | 19q13.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of DBP. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by DBP. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | DBP |
Name | D site of albumin promoter (albumin D-box) binding protein |
Aliases | DABP; albumin D box-binding protein; albumin D-element-binding protein; tax-responsive enhancer element-bind ...... |
Chromosomal Location | 19q13.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of DBP. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | DBP |
Name | D site of albumin promoter (albumin D-box) binding protein |
Aliases | DABP; albumin D box-binding protein; albumin D-element-binding protein; tax-responsive enhancer element-bind ...... |
Chromosomal Location | 19q13.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of DBP expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | DBP |
Name | D site of albumin promoter (albumin D-box) binding protein |
Aliases | DABP; albumin D box-binding protein; albumin D-element-binding protein; tax-responsive enhancer element-bind ...... |
Chromosomal Location | 19q13.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between DBP and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | DBP |
Name | D site of albumin promoter (albumin D-box) binding protein |
Aliases | DABP; albumin D box-binding protein; albumin D-element-binding protein; tax-responsive enhancer element-bind ...... |
Chromosomal Location | 19q13.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting DBP collected from DrugBank database. |
There is no record. |