Browse DCLK1

Summary
SymbolDCLK1
Namedoublecortin-like kinase 1
Aliases KIAA0369; DCLK; DCDC3A; DCAMKL1; doublecortin and CaM kinase-like 1; CLICK1; doublecortin domain-containing ......
Chromosomal Location13q13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location -
Domain PF03607 Doublecortin
PF00069 Protein kinase domain
Function

Probable kinase that may be involved in a calcium-signaling pathway controlling neuronal migration in the developing brain. May also participate in functions of the mature nervous system.

> Gene Ontology
 
Biological Process GO:0001764 neuron migration
GO:0007034 vacuolar transport
GO:0007409 axonogenesis
GO:0009615 response to virus
GO:0016049 cell growth
GO:0016197 endosomal transport
GO:0016358 dendrite development
GO:0018105 peptidyl-serine phosphorylation
GO:0018209 peptidyl-serine modification
GO:0021952 central nervous system projection neuron axonogenesis
GO:0021953 central nervous system neuron differentiation
GO:0021954 central nervous system neuron development
GO:0021955 central nervous system neuron axonogenesis
GO:0030900 forebrain development
GO:0034504 protein localization to nucleus
GO:0048588 developmental cell growth
GO:0048667 cell morphogenesis involved in neuron differentiation
GO:0048675 axon extension
GO:0048813 dendrite morphogenesis
GO:0060560 developmental growth involved in morphogenesis
GO:0061564 axon development
GO:1900180 regulation of protein localization to nucleus
GO:1900181 negative regulation of protein localization to nucleus
GO:1903828 negative regulation of cellular protein localization
GO:1990138 neuron projection extension
Molecular Function GO:0004674 protein serine/threonine kinase activity
GO:0005057 receptor signaling protein activity
Cellular Component -
> KEGG and Reactome Pathway
 
KEGG -
Reactome -
Summary
SymbolDCLK1
Namedoublecortin-like kinase 1
Aliases KIAA0369; DCLK; DCDC3A; DCAMKL1; doublecortin and CaM kinase-like 1; CLICK1; doublecortin domain-containing ......
Chromosomal Location13q13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between DCLK1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 
  Literatures describing the relation between DCLK1 and anti-tumor immunity in human cancer.
PMID Cancer type Relation to immunity Evidence sentences
29604293Pancreatic ductal adenocarcinoma; melanoma; colon carcinomaInhibit immunityIn human pancreatic tumor tissues, high levels of DCLK1 associated with a shorter median survival time of patients (17.7 months, compared with 26.6 months of patients whose tumors had low levels of DCLK1).
Summary
SymbolDCLK1
Namedoublecortin-like kinase 1
Aliases KIAA0369; DCLK; DCDC3A; DCAMKL1; doublecortin and CaM kinase-like 1; CLICK1; doublecortin domain-containing ......
Chromosomal Location13q13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of DCLK1 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolDCLK1
Namedoublecortin-like kinase 1
Aliases KIAA0369; DCLK; DCDC3A; DCAMKL1; doublecortin and CaM kinase-like 1; CLICK1; doublecortin domain-containing ......
Chromosomal Location13q13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of DCLK1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14120.540.352
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)651.0090.499
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)870.20.862
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-1.2380.0278
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-1.2260.547
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47-1.2540.623
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.0180.969
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-0.0730.96
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.080.961
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.1250.901
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.6810.642
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.3580.167
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of DCLK1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27733.75.5-1.81
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27593.76.8-3.11
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21179.509.50.492
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)131115.4015.40.482
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91611.112.5-1.41
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 592011.18.91
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47014.3-14.31
1329033130MelanomaallAnti-PD-1 (nivolumab) 38277.907.90.26
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 221313.6013.60.279
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolDCLK1
Namedoublecortin-like kinase 1
Aliases KIAA0369; DCLK; DCDC3A; DCAMKL1; doublecortin and CaM kinase-like 1; CLICK1; doublecortin domain-containing ......
Chromosomal Location13q13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of DCLK1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolDCLK1
Namedoublecortin-like kinase 1
Aliases KIAA0369; DCLK; DCDC3A; DCAMKL1; doublecortin and CaM kinase-like 1; CLICK1; doublecortin domain-containing ......
Chromosomal Location13q13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of DCLK1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by DCLK1.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolDCLK1
Namedoublecortin-like kinase 1
Aliases KIAA0369; DCLK; DCDC3A; DCAMKL1; doublecortin and CaM kinase-like 1; CLICK1; doublecortin domain-containing ......
Chromosomal Location13q13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of DCLK1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolDCLK1
Namedoublecortin-like kinase 1
Aliases KIAA0369; DCLK; DCDC3A; DCAMKL1; doublecortin and CaM kinase-like 1; CLICK1; doublecortin domain-containing ......
Chromosomal Location13q13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of DCLK1 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolDCLK1
Namedoublecortin-like kinase 1
Aliases KIAA0369; DCLK; DCDC3A; DCAMKL1; doublecortin and CaM kinase-like 1; CLICK1; doublecortin domain-containing ......
Chromosomal Location13q13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between DCLK1 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolDCLK1
Namedoublecortin-like kinase 1
Aliases KIAA0369; DCLK; DCDC3A; DCAMKL1; doublecortin and CaM kinase-like 1; CLICK1; doublecortin domain-containing ......
Chromosomal Location13q13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting DCLK1 collected from DrugBank database.
> Drugs from DrugBank database
 

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