Summary | |
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Symbol | DCT |
Name | dopachrome tautomerase |
Aliases | dopachrome delta-isomerase; TYRP2; tyrosine-related protein 2; TRP-2; L-dopachrome Delta-isomerase; dopachro ...... |
Chromosomal Location | 13q32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Melanosome membrane Single-pass type I membrane protein Melanosome Note=Proper trafficking to melanosome is regulated by SGSM2, ANKRD27, RAB9A, RAB32 and RAB38. |
Domain |
PF00264 Common central domain of tyrosinase |
Function |
Catalyzes the conversion of L-dopachrome into 5,6-dihydroxyindole-2-carboxylic acid (DHICA) (PubMed:8306979). Involved in regulating eumelanin and phaeomelanin levels. |
Biological Process |
GO:0002052 positive regulation of neuroblast proliferation GO:0006570 tyrosine metabolic process GO:0006582 melanin metabolic process GO:0006583 melanin biosynthetic process from tyrosine GO:0007405 neuroblast proliferation GO:0008544 epidermis development GO:0009072 aromatic amino acid family metabolic process GO:0010720 positive regulation of cell development GO:0017145 stem cell division GO:0018958 phenol-containing compound metabolic process GO:0019748 secondary metabolic process GO:0021846 cell proliferation in forebrain GO:0021847 ventricular zone neuroblast division GO:0021869 forebrain ventricular zone progenitor cell division GO:0021872 forebrain generation of neurons GO:0021873 forebrain neuroblast division GO:0030900 forebrain development GO:0036445 neuronal stem cell division GO:0042438 melanin biosynthetic process GO:0042440 pigment metabolic process GO:0043473 pigmentation GO:0044550 secondary metabolite biosynthetic process GO:0046148 pigment biosynthetic process GO:0046189 phenol-containing compound biosynthetic process GO:0048066 developmental pigmentation GO:0048103 somatic stem cell division GO:0050769 positive regulation of neurogenesis GO:0051962 positive regulation of nervous system development GO:0055057 neuroblast division GO:0061351 neural precursor cell proliferation GO:0072089 stem cell proliferation GO:0072091 regulation of stem cell proliferation GO:1901605 alpha-amino acid metabolic process GO:1901615 organic hydroxy compound metabolic process GO:1901617 organic hydroxy compound biosynthetic process GO:1902692 regulation of neuroblast proliferation GO:2000177 regulation of neural precursor cell proliferation GO:2000179 positive regulation of neural precursor cell proliferation GO:2000648 positive regulation of stem cell proliferation |
Molecular Function |
GO:0004167 dopachrome isomerase activity GO:0005507 copper ion binding GO:0016853 isomerase activity GO:0016860 intramolecular oxidoreductase activity GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds |
Cellular Component |
GO:0030659 cytoplasmic vesicle membrane GO:0033162 melanosome membrane GO:0042470 melanosome GO:0045009 chitosome GO:0048770 pigment granule |
KEGG |
hsa04916 Melanogenesis hsa00350 Tyrosine metabolism hsa01100 Metabolic pathways |
Reactome |
R-HSA-5662702: Melanin biosynthesis R-HSA-1430728: Metabolism R-HSA-71291: Metabolism of amino acids and derivatives |
Summary | |
---|---|
Symbol | DCT |
Name | dopachrome tautomerase |
Aliases | dopachrome delta-isomerase; TYRP2; tyrosine-related protein 2; TRP-2; L-dopachrome Delta-isomerase; dopachro ...... |
Chromosomal Location | 13q32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between DCT and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between DCT and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | DCT |
Name | dopachrome tautomerase |
Aliases | dopachrome delta-isomerase; TYRP2; tyrosine-related protein 2; TRP-2; L-dopachrome Delta-isomerase; dopachro ...... |
Chromosomal Location | 13q32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of DCT in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | DCT |
Name | dopachrome tautomerase |
Aliases | dopachrome delta-isomerase; TYRP2; tyrosine-related protein 2; TRP-2; L-dopachrome Delta-isomerase; dopachro ...... |
Chromosomal Location | 13q32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of DCT in various data sets.
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Points in the above scatter plot represent the mutation difference of DCT in various data sets.
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Summary | |
---|---|
Symbol | DCT |
Name | dopachrome tautomerase |
Aliases | dopachrome delta-isomerase; TYRP2; tyrosine-related protein 2; TRP-2; L-dopachrome Delta-isomerase; dopachro ...... |
Chromosomal Location | 13q32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of DCT. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | DCT |
Name | dopachrome tautomerase |
Aliases | dopachrome delta-isomerase; TYRP2; tyrosine-related protein 2; TRP-2; L-dopachrome Delta-isomerase; dopachro ...... |
Chromosomal Location | 13q32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of DCT. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by DCT. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | DCT |
Name | dopachrome tautomerase |
Aliases | dopachrome delta-isomerase; TYRP2; tyrosine-related protein 2; TRP-2; L-dopachrome Delta-isomerase; dopachro ...... |
Chromosomal Location | 13q32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of DCT. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | DCT |
Name | dopachrome tautomerase |
Aliases | dopachrome delta-isomerase; TYRP2; tyrosine-related protein 2; TRP-2; L-dopachrome Delta-isomerase; dopachro ...... |
Chromosomal Location | 13q32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of DCT expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | DCT |
Name | dopachrome tautomerase |
Aliases | dopachrome delta-isomerase; TYRP2; tyrosine-related protein 2; TRP-2; L-dopachrome Delta-isomerase; dopachro ...... |
Chromosomal Location | 13q32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between DCT and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | DCT |
Name | dopachrome tautomerase |
Aliases | dopachrome delta-isomerase; TYRP2; tyrosine-related protein 2; TRP-2; L-dopachrome Delta-isomerase; dopachro ...... |
Chromosomal Location | 13q32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting DCT collected from DrugBank database. |
There is no record. |